... and because some, including N-CAM, are involved in neural development, we were interested in their pattern of expression in the splotch mutant. Immunolocalization studies showed similar temporospatial distributions of N-CAM antibody in embryonic day 9 mutants and controls. However, mutant embryos had a much...

...Sylvie Boisseau; Joël Nedelec; Véronique Poirier; Geneviève Rougon; Michel Simonneau ABSTRACT Using a monoclonal antibody that recognizes specifically a high polysialylated form of N-CAM (high PSA N-CAM), the temporal and spatial expression of this molecule was studied in developing spinal cord...

...Martin Bastmeyer; Burkhard Schlosshauer; Claudia A. O. Stuermer The spatiotemporal distribution of neural cell adhesion molecule (N-CAM) in the retinotectal system of adult goldfish was assessed by immunofluorescence using the monoclonal antibody (Mab) D3 against chick N-CAM. In immunoblots...

...Jean-Pierre Saint-Jeannet; Françoise Foulquier; Christo Goridis; Anne-Marie Duprat ABSTRACT The appearance and localization of N-CAM during neural induction were studied in Pleurodeles waltl embryos and compared with recent contradictory results reported in Xenopus laevis . A monoclonal antibody...

...S. J. Croucher; C. Tickle ABSTRACT The formation of the nasal passages involves complex morphogenesis and their lining develops a spatially ordered pattern of differentiation, with distinct domains of olfactory and respiratory epithelium. Using antibodies to the neural cell adhesion molecule (N-CAM...

...Frank S. Walsh; Raj B. Parekh; Stephen E. Moore; George Dickson; C. Howard Barton; Hilary J. Gower; Raymond A. Dwek; Thomas W. Rademacher ABSTRACT We have shown previously that the predominant N-CAM isoform in skeletal muscle myotubes contains as a result of alternative splicing a novel domain...

...C. Howard Barton; George Dickson; Hilary J. Gower; Lewis H. Rowett; Wendy Putt; Vicki Elsom; Stephen E. Moore; Christo Goridis; Frank S. Walsh ABSTRACT Neural cell adhesion molecules (N-CAMs) are a family of cell surface sialoglycoproteins encoded by a single copy gene. A full-length cDNA clone...

...Kieran C. Breen; Ciaran M. Regan ABSTRACT A rat brain Golgi sialyltransferase activity capable of the differentiation-dependent control of N-CAM sialylation state is described. The specific activity of Golgi sialyltransferase was found to be developmentally regulated with respect to both endogenous...

... ( Rogers et al . 1983 ), laminin ( Rogers et al . 1983 ; Hammarback, Palm, Furcht & Letourneau, 1985 ) and collagen ( Roufa, Johnston & Bunge, 1983 ) have all been shown to promote neurite outgrowth. A cell adhesion molecule, N-CAM, has been shown to increase in the innervated sensory areas...

...B. K. Kay; L. M. Schwartz; U. Rutishauser; T. H. Qiu; H. B. Peng The neural cell adhesion molecule (N-CAM) is seen in the membrane of nerves and muscles from several vertebrate species. Using indirect immunofluorescence, we have examined the expression of this protein during embryonic...

...C. R. Kintner; D. A. Melton ABSTRACT We have isolated Xenopus laevis N-CAM cDNA clones and used these to study the expression of N-CAM RNA during neural induction. The results show that the first marked increase in N-CAM RNA levels occurs during gastrulation when mesoderm comes in contact...