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Keywords: Myosin
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Journal Articles
Journal: Development
Development (2020) 147 (17): dev186502.
Published: 02 September 2020
... of network assembly, and provides insights into cell ratcheting, force transmission and pulsatility. Myosin Actin Morphogenesis Pulsatility Ratcheting Any observer who has watched an animal embryo develop has seen that the tissues that make up the embryo show a remarkable dynamism; indeed...
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184689.
Published: 28 April 2020
... work is properly attributed. Highlighted Article: Tbx16 and Tbxta activate myf5 and myod directly during the earliest myogenesis in zebrafish, and Fgf signalling acts through Tbx16 to drive myogenesis in trunk but not tail. Muscle Zebrafish Myosin Myod Myf5 Myogenin Hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev172577.
Published: 03 June 2019
... withdrawal is independent of ECM degradation and is driven by myosin II-dependent contraction. These results reveal a surprising physical and functional cell-matrix uncoupling in a monolayer epithelium under tension during development. This article has an associated ‘The people behind the papers’ interview...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168922.
Published: 12 December 2018
... of actomyosin activity, induces apical constriction, which is required for bottle cell formation during Xenopus gastrulation. Apical constriction Bottle cell Gastrulation RhoGEF Actin Myosin Xenopus Apical constriction refers to an active reduction of cell apical surface area...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4249–4260.
Published: 01 December 2017
... Myosin Tension In On Growth and Form , D'Arcy Thompson proposed that an organism's form is a ʻdiagram of the forces' that have acted and continue to act upon it ( Thompson, 1917 ). At the time of its publication, what those forces were and how they were generated was a mystery. However, 100...
Journal Articles
Journal: Development
Development (2017) 144 (16): 2961–2968.
Published: 15 August 2017
..., individual DBs elongate as a cluster of cells, led by tip cells at the front and trailing cells in the rear. Branch elongation is accompanied by extensive cell intercalation and cell lengthening of the trailing stalk cells. Although cell intercalation is governed by Myosin II (MyoII)-dependent forces during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2153–2164.
Published: 15 June 2017
... neuroblasts as a model to study the apical constriction process during cell delamination. We observe dynamic myosin signals both around the cell adherens junctions and underneath the cell apical surface in the neuroectoderm. On the cell apical cortex, the nonjunctional myosin forms flows and pulses, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1876–1886.
Published: 15 May 2017
...Natalie C. Heer; Pearson W. Miller; Soline Chanet; Norbert Stoop; Jörn Dunkel; Adam C. Martin Tissue folding promotes three-dimensional (3D) form during development. In many cases, folding is associated with myosin accumulation at the apical surface of epithelial cells, as seen in the vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4137–4148.
Published: 15 November 2016
... inhibition of miR-501 dramatically blunted the induction of embryonic myosin heavy chain (MYH3) and, to a lesser extent, adult myosin isoforms during muscle regeneration, and promoted small-diameter neofibers. An unbiased target identification approach in primary myoblasts validated gigaxonin as a target...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 715–727.
Published: 15 February 2016
... that depletion of myosin regulatory light chain (RLC) levels in the embryo blocks force generation at gastrulation through two distinct mechanisms: destabilizing the myosin II (MII) hexameric complex and inhibiting MII contractility. Molecular dissection of these two mechanisms demonstrates that normal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 1987–1998.
Published: 15 May 2014
... understanding how the distinct cell biological processes that together drive apical constriction are coordinated. These processes include the contraction of actin-myosin networks, which generates force, and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted between...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1789–1793.
Published: 01 May 2014
...Akankshi Munjal; Thomas Lecuit Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces...
Journal Articles
Journal: Development
Development (2013) 140 (11): 2321–2333.
Published: 01 June 2013
... Sprouting angiogenesis Actin Myosin Mouse Blood vessel network formation by sprouting angiogenesis involves a sequence of morphogenic events including the initial formation, guidance and extension of sprouts, anastomosis and lumen formation, allowing the formation of new vascular loops ( Potente...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3955–3966.
Published: 15 September 2011
...Catrin Sian Rutland; Luis Polo-Parada; Elisabeth Ehler; Aziza Alibhai; Aaran Thorpe; Suganthi Suren; Richard D. Emes; Bhakti Patel; Siobhan Loughna The expression and function of embryonic myosin heavy chain (eMYH) has not been investigated within the early developing heart. This is despite...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1991–2001.
Published: 15 May 2011
...). In response the PFCs generate an unidentified polarizing signal that regulates oocyte polarity. We have identified a loss-of-function mutation of flapwing , which encodes the catalytic subunit of Protein Phosphatase 1β (PP1β) that disrupts oocyte polarization. We show that PP1β, by regulating myosin activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 371–384.
Published: 15 January 2011
... signals) slow myogenesis by stimulating the expression of slow myosin heavy chain. Also, fibroblasts promote the switch from fetal to adult muscle by repressing (via Tcf4-dependent signals) the expression of developmental embryonic myosin and promoting (via a Tcf4-independent mechanism) the formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1645–1655.
Published: 15 May 2010
... and regulation of actomyosin assemblies. We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical constriction at Drosophila dorsal closure. The PAR complex and myosin accumulate at the apical surface domain...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 795–804.
Published: 01 March 2010
... separation along the midline at rhombomere boundaries, subsequent openings within rhombomeres and eventual coalescence of openings into the hindbrain ventricle lumen. A mutation in the myosin phosphatase regulator mypt1 results in a small ventricle due to impaired stretching of the surrounding...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 403–414.
Published: 01 February 2009
... in this novel two-component myogenic system facilitated the diversification of vertebrates. † Author for correspondence( simon.hughes@kcl.ac.uk ) * These authors contributed equally to this work 17 11 2008 © 2009. 2009 Muscle Zebrafish Myosin Slow Fibre Fast Head Fin mrf4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2435–2444.
Published: 15 July 2008
... and elongate the body axis, to examine the role of myosin IIB in convergence and extension. We find that myosin IIB is localized in the cortex of intercalating cells, and show by morpholino knockdown that this myosin isoform is essential for the maintenance of a stereotypical, cortical actin cytoskeleton...
Includes: Multimedia, Supplementary data