... to be necessary for the survival of skeletal myoblasts and for the efficient formation of intact myotubes. Our findings reveal a central role for MRTFs in sarcomere formation during skeletal muscle development and point to the potential involvement of these transcriptional co-activators in skeletal myopathies...

... of contractile function and progression towards inherited or acquired myopathic disease. * Author for correspondence (e-mail: [email protected] ) 21 11 2008 © 2009. 2009 Prox1 Mouse Heart development Myocardium Sarcomere Hypertrophy Myopathy N-RAP (Nrap) Zyxin Cardiac...

... receptors in skeletal muscle, and mutations that affect the α7β1 integrin cause myopathy in humans. In mice, β1 integrins control myoblast fusion, the assembly of the muscle fiber cytoskeleton, and the maintenance of myotendinous junctions (MTJs). The effector molecules that mediate β1 integrin functions...