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Keywords: Myofibroblast
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Journal Articles
Journal: Development
Development (2024) 151 (9): dev202659.
Published: 13 May 2024
... organism. The first phase of alveologenesis involves the formation of septal ridges (secondary septae) and the second phase involves thinning of the alveolar septa. Within secondary septa, mesenchymal cells include a transient population of alveolar myofibroblasts (MyoFBs) and a stable but poorly described...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (5): dev200839.
Published: 3 March 2023
... smaller than wild-type and Sp +/− littermates, died soon after birth and had abnormal lung morphogenesis. RNA-seq of Sp3 −/− fetal lung mesenchymal cells identified alterations in extracellular matrix production, developmental signaling pathways and myofibroblast/lipofibroblast differentiation. The lungs...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
...Andrew S. Hagan; Bo Zhang; David M. Ornitz ABSTRACT Alveologenesis is an essential developmental process that increases the surface area of the lung through the formation of septal ridges. In the mouse, septation occurs postnatally and is thought to require the alveolar myofibroblast (AMF). Though...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2019) 146 (20): dev180430.
Published: 18 October 2019
... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3336–3348.
Published: 15 September 2017
... factor beta (TGFβ) signalling is essential for VBW closure, but the responding cells are not known. Here, we identify in mouse a population of migratory myofibroblasts at the leading edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFβ receptor (TGFβR). These cells...
Includes: Supplementary data