... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...

...Leshana Saint-Jean; Nikolaos Barkas; Cristina Harmelink; Kevin L. Tompkins; Rebecca J. Oakey; H. Scott Baldwin ABSTRACT The endocardium interacts with the myocardium to promote proliferation and morphogenesis during the later stages of heart development. However, the role of the endocardium...

... are magnified on the right. (G-I) Volume rendering of ET33-mi60a;myl7:mRFP injured ventricles. Endocardium, green; myocardium, magenta. (J,J′) Volume rendering (J) and amplified optical section from the centre (J′) of an injured ventricle. (K) Imaris-based volume quantification. The volume of the mRFP...

... interactions involved in establishing endocardial identity are poorly understood. The endocardium develops in tight association with cardiomyocytes. To test for a potential role of the myocardium in endocardial morphogenesis, we used two different zebrafish models deficient in cardiomyocytes: the hand2 mutant...

... with the evolutionary need for a fully divided circulation. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 24 2 2011 © 2011. 2011 Cardiac cushion Myocardium Outflow tract Spiral septum Neural...

...Mary Redmond Hutson; Xiaopei Lily Zeng; Andrew J. Kim; Emily Antoon; Stephen Harward; Margaret L. Kirby During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole...

... of contractile function and progression towards inherited or acquired myopathic disease. * Author for correspondence (e-mail: [email protected] ) 21 11 2008 © 2009. 2009 Prox1 Mouse Heart development Myocardium Sarcomere Hypertrophy Myopathy N-RAP (Nrap) Zyxin Cardiac...

... or heart are unknown. Eya4 Na + /K + -ATPase Hair cells Myocardium Neuromast Otic vesicle © 2008. 2008 13 8 2008 * These authors contributed equally to this work † Author for correspondence (e-mail: [email protected] ) ...

..., each spanning 1 μm,were acquired per section and processed with Zeiss Axiovision software to produce a compressed z -stack image. Representative images are at 400× magnification. VEGFA, VEGFB and VEGFC expression was quantified by measuring the immunofluorescent signal in both the myocardium...

... tube assembly. Together, our data reveal a dynamic cellular mechanism by which tissue interactions establish organ architecture. * Author for correspondence (e-mail: [email protected] ) 28 3 2007 © 2007. 2007 Endocardium Myocardium Zebrafish cloche miles apart (edg5...

... the myocardium for normal heart morphogenesis and that this function depends on its catalytic activity. In addition, we demonstrate that nagie oko (Nok) is the functional homolog of mammalian protein associated with Lin-seven 1 (Pals1)/MAGUK p55 subfamily member 5(Mpp5), and we dissect its earlier and later...

.... In the mouse, Tbx20 is expressed in the cardiac crescent, then in the endocardium and myocardium of the linear and looped heart tube before it is restricted to the atrioventricular canal and outflow tract in the multi-chambered heart. Here, we show that Tbx20 is required for progression from the linear heart...

... consisting of two tissue layers, the myocardium and endocardium. The cellular and molecular mechanisms responsible for the separation of ventricular and atrial lineages are not well understood. To test models of cardiac chamber specification, we generated a high-resolution fate map of cardiac chamber...

... from acute heart failure, with reduced proliferation of ventricular myocardium. The myocardial defect may involve reduced BMP signaling in a novel, minor population of neural crest derivatives in the epicardium, a known source of ventricular myocardial proliferation signals. These results demonstrate...

... the onset of cardiac differentiation in the frog embryo and is expressed throughout all the myocardium, both before and after heart chamber formation. Using transgenesis in frog embryos, we have identified an 82 bp enhancer within the proximal promoter region of the gene that is necessary and sufficient...

..., as the ventricular wall thickens, wedge shaped clusters traverse the wall and contain rows of cells at a progressive angle to each other. The cellular organisation of the myocardium appears to prefigure myofibre architecture. We discuss how the characteristics of myocardial cell growth, which we describe, underlie...

... of three different types of ET receptors, ET A , ET B and ET B2 , in the embryonic chick heart. Whole-mount in situ hybridization analyses revealed that ET A was ubiquitously expressed in both ventricular and atrial myocardium during heart development, while ET B was predominantly expressed in the atrium...

.... Earlier mapping studies of the heart fields performed in whole embryo cultures indicate that all of the myocardium of the developed heart originates from the primary heart fields. In contrast, marking experiments in ovo suggest that the atrioventricular canal, atria and conotruncus are added secondarily...

[email protected] ) 15 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 One of the primary patterning decisions required...

... to involve the Nodal / Lefty / Pitx2 pathway. Histological and molecular analysis reveal distinct anteroposterior components in the mutant heart tube, although posterior chamber (atria and sinus venosus) development is severely impaired. Instead of forming trabeculae, the developing ventricular myocardium...