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Keywords: MyoD
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Journal Articles
Journal: Development
Development (2020) 147 (8): dev184689.
Published: 28 April 2020
... and myod genes, which are required for commitment to myogenesis. Tbx16 activity depends on Fgf signalling from the organiser. In contrast, Tbxta is not required for myf5 expression, but binds a specific site upstream of myod that is not bound by Tbx16 and drives (dependent on Fgf signals) myod expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4914–4925.
Published: 15 December 2013
... in the establishment of the muscle phenotype remains elusive. Here, we show that the NFAT member NFATc2 cooperates with the basic helix-loop-helix transcription factor MyoD to induce the expression of a specific myosin heavy chain (MHC) isoform, the neonatal one, during embryogenesis. We found this cooperation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 958–967.
Published: 01 March 2012
...Natalia Moncaut; Joe W. Cross; Christine Siligan; Annette Keith; Kevin Taylor; Peter W. J. Rigby; Jaime J. Carvajal The specification of the skeletal muscle lineage during craniofacial development is dependent on the activity of MYF5 and MYOD, two members of the myogenic regulatory factor family...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2935–2945.
Published: 15 July 2011
... and differentiation into fibers, demonstrating that regulation of pioneer patterning is somite-intrinsic. Furthermore, pioneer myoblasts express Robo2 downstream of MyoD and Myf5, whereas the dermomyotome and caudal sclerotome express Slit1. Loss of Robo2 or of sclerotome-derived Slit1 function perturbed both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1241–1249.
Published: 15 April 2009
...-defined transcriptional cascade that is evolutionarily conserved. Cascade components include homeobox-containing factors (PAX-3/7), which activate a set of four related basic helix-loop-helix (bHLH) factors (MyoD, MYF-5, MRF-4 and myogenin; a.k.a. MRFs) that work in concert with MADS box factors (MEF-2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 403–414.
Published: 01 February 2009
...Yaniv Hinits; Daniel P. S. Osborn; Simon M. Hughes Myogenic regulatory factors of the Myod family (MRFs) are transcription factors essential for mammalian skeletal myogenesis. However,the roles of each gene in myogenesis remain unclear, owing partly to genetic linkage at the Myf5/Mrf4 locus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3371–3382.
Published: 15 September 2007
...Lisa Maves; Andrew Jan Waskiewicz; Biswajit Paul; Yi Cao; Ashlee Tyler; Cecilia B. Moens; Stephen J. Tapscott The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod-driven...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2579–2591.
Published: 15 July 2007
... tissue sections as previously described ( Edom-Vovard et al.,2002 ). The digoxigenin-labeled mRNA probes were used as described: Pax3, MyoD, Fgfr4 and mouse MyoD ( Delfini and Duprez, 2004 ),quail Vegfr2 ( Eichmann et al.,1993 ), Hif2 α( Favier et al., 1999 ), Pdgfb ( Horiuchi et al.,2002...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (6): 1101–1112.
Published: 15 March 2006
... to a shift in mitotic orientation and to fate segregation. Site-directed electroporation to additional, discrete somite regions, further reveals that N-cadherin-mediated adhesion is necessary for maintaining the epithelial configuration of all dermomyotome domains while promoting the onset of Myod...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (2): 195–208.
Published: 15 January 2006
... at least in part from a lack of myoblast proliferation in the hypaxial muscle domain. Conversely, overexpression of lbx1 mRNA results in enlarged somites, an increase in cell proliferation, but a lack of differentiated muscle. The control of cell proliferation is linked to a strong downregulation of myoD...
Journal Articles
Journal: Development
Development (2005) 132 (19): 4211–4222.
Published: 01 October 2005
...Julie A. Groves; Christina L. Hammond; Simon M. Hughes Fibroblast growth factors (Fgfs) have long been implicated in regulating vertebrate skeletal muscle differentiation, but their precise role(s) in vivo remain unclear. Here, we show that Fgf8 signalling in the somite is required for myod...
Journal Articles
Journal: Development
Development (2005) 132 (18): 4119–4130.
Published: 15 September 2005
.... elegans Myod homolog HLH-1 acts downstream of mls-2 to specify M-derived coelomocyte cell fates. Thus MLS-2 functions in a cell type-specific manner to regulate both cell proliferation and cell fate specification. Since loss or gain of mls-2 function caused proliferation defects in the M lineage, we...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1795–1805.
Published: 15 April 2005
... activate hlh-1 in blastomeres that either lack POP-1/TCF or that have down-regulated POP-1/TCF in response to Wnt/MAP kinase signaling. The potent myogenic activity of HLH-1 highlights the remarkable developmental plasticity of early C. elegans blastomeres and reveals the evolutionary conservation of MyoD...
Journal Articles
Journal: Development
Development (2005) 132 (3): 447–458.
Published: 01 February 2005
... propose that this occurs through mechanism resembling myotomal extension and is substantiated by the co-expression of MyoD and the Pax genes. The deployment of an extension mechanism as opposed to migration of individual precursors is supported by our observations of SF/HGF expression during...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3967–3980.
Published: 15 August 2004
... and differentiation of graft-derived cells were assayed using QCPN and QH1 antibodies to identify all quail cells and quail endothelial cells, respectively. Chimeric embryos were assayed for expression of myf5, myod, paraxis and lbx1 , and the synthesis of myosin heavy chain (MyHC), between 1 and 6 days later (stages...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3249–3262.
Published: 15 July 2004
...: simon.hughes@kcl.ac.uk ) * These authors contributed equally to this work † Present address: University of Insubria, Department of Structural and Functional Biology, via J.H. Dunant 3, 21100 Varese, Italy 19 3 2004 © 2004. 2004 Dermomyotome Slow muscle MyoD Pax3 Myf5...
Journal Articles
Journal: Development
Development (2004) 131 (6): 1319–1330.
Published: 15 March 2004
... domain is necessary for Mash1 to be able to promote neuronal differentiation, and is sufficient to confer this activity to the non-neural bHLH factor MyoD. In contrast, helix 2 of Math1, and both helix 1 and 2 of Mash1, are the domains required for the neuronal specification activities of these factors...
Journal Articles
Journal: Development
Development (2004) 131 (4): 713–723.
Published: 15 February 2004
...Marie-Claire Delfini; Delphine Duprez Forced expression of the bHLH myogenic factors, Myf5 and MyoD, in various mammalian cell lines induces the full program of myogenic differentiation. However, this property has not been extensively explored in vivo. We have taken advantage of the chick model...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4797–4807.
Published: 15 October 2003
... this discrepancy, we have re-addressed this issue, using short-term in vivo microsurgery and culture experiments in chick. Our results show that the initial expression of the muscle-specific markers Myf5 and MyoD is regulated in a mesoderm-autonomous fashion. The reception of a Wnt signal is required for MyoD...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2239–2252.
Published: 15 May 2003
.... Six1 –/– embryos have impaired primary myogenesis, characterized, at E13.5, by a severe reduction and disorganisation of primary myofibers in most body muscles. While Myf5,MyoD and myogenin are correctly expressed in the somitic compartment in early Six1 –/– embryos, by E11.5 MyoD and myogenin gene...