... ). Two myogenic lineages within the developing somite . Development 114 , 339 – 353 . 10.1242/dev.114.2.339 Ott , M. O. , Bober , E. , Lyons , G. , Arnold , H. and Buckingham , M. ( 1991 ). Early expression of the myogenic regulatory gene, myf-5, in precursor cells...

... . Anat. Embryol . 188 , 239 – 245 . 10.1007/BF00188215 Braun , T. and Arnold , H. H. ( 1996 ). Myf-5 and myoD genes are activated in distinct mesenchymal stem cells and determine different skeletal muscle cell lineages . Embo J . 15 , 310 – 18 . 10.1002/j.1460-2075.1996...

..., respectively, of the developing somite. To investigate the hypothesis that Myf-5 and MyoD have different roles in the development of epaxial and hypaxial musculature, we further characterized myogenesis in Myf-5- and MyoD -deficient embryos by several approaches. We examined expression of a MyoD-lacZ transgene...

...Stefanie Grass; Hans-Henning Arnold; Thomas Braun ABSTRACT Mice carrying a targeted mutation in the gene for the myogenic factor Myf-5 fail to form major parts of the ribs, which leads to an unstable thorax and perinatal death. Here, we report that somites of Myf-5 -deficient mice lack...

...Shahragim Tajbakhsh; Margaret E. Buckingham ABSTRACT myf-5 is one of four transcription factors belonging to the MyoD family that play key roles in skeletal muscle determination and differentiation. We have shown earlier by gene targeting nlacZ into the murine myf-5 locus that myf-5 expression...

...Thomas Braun; Eva Bober; Michael A. Rudnicki; Rudolf Jaenisch; Hans-Henning Arnold ABSTRACT The expression pattern of myogenic regulatory factors and myotome-specific contractile proteins was studied during embryonic development of Myf-5 mutant mice by in situ hybridization and immunohistochemistry...

... from deficiency of Pax-3 expression in the segmental plate, when these cells transiently express Pax-3 at a stage prior to migration, or to other as yet unknown regulatory events. We acknowledge the generous gifts of the avian Pax-3 probe from Peter Gruss, the avian myf-5 probe from...

... of muscle phenotypes at later times, raises the issue of how MyoD family genes are themselves regulated during development. In this work, we have initiated studies to identify DNA sequences that govern Myf-5 and MRF4 ( herculin, myf-6 ) transcription. Myf-5 is the first of the MyoD family to be expressed...

...Marie-Odile Ott; Eva Bober; Gary Lyons; Hans Arnold; Margaret Buckingham ABSTRACT We have analysed by in situ hybridization the expression of myf-5 , the murine homologue of the human myogenic regulatory sequence myf5, during embryogenesis in the mouse, myf-5 sequences were first detected...