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Keywords: Mutant
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199675.
Published: 24 December 2021
...Hussein A. Saud; Paul A. O'Neill; Yosuke Ono; Bas Verbruggen; Ronny Van Aerle; Jaebum Kim; Jae-Seong Lee; Brian C. Ring; Tetsuhiro Kudoh ABSTRACT Using the self-fertilizing mangrove killifish, we characterized two mutants, shorttail ( stl ) and balltail ( btl ). These mutants showed abnormalities...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155366.
Published: 9 January 2018
... nanog (maternal and zygotic null) mutant zebrafish embryos . Without functional Nanog, epiboly is severely affected, embryo axes do not form and massive cell death starts at the end of gastrulation. We show that three independent defects in MZ nanog mutants contribute to epiboly failure: yolk...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4280–4290.
Published: 15 November 2012
...Nikolaus Obholzer; Ian A. Swinburne; Evan Schwab; Alex V. Nechiporuk; Teresa Nicolson; Sean G. Megason Forward genetic screens in zebrafish have identified >9000 mutants, many of which are potential disease models. Most mutants remain molecularly uncharacterized because of the high cost, time...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2521–2531.
Published: 1 July 2007
... or western blot. The mutant esophagus morphologically resembles the trachea,with ectopic expression of Nkx2.1, a columnar, ciliated epithelium, and very few p63 + basal cells. By contrast, the abnormal foregut of Nkx2.1 -null embryos expresses elevated Sox2 and p63, suggesting reciprocal regulation of Sox2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 2955–2967.
Published: 1 July 2005
... phenotypes. Thirteen recessive mutations in 12 genes were discovered. In one mutant, ddl , the majority of RGCs fail to differentiate. Three of the mutations, vrt , late and tard , delay the orderly ingrowth of retinal axons into the tectum. Two alleles of drg disrupt the layer-specific targeting of retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1699–1711.
Published: 1 April 2005
... studied as a paradigm of tissue pattern formation in plants. To elucidate the molecular mechanism controlling the vein patterning process,we previously isolated Arabidopsis mutants van1 to van7 , which show a discontinuous vein pattern. Here we report the phenotypic analysis of the van3 mutant in relation...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2779–2791.
Published: 15 June 2003
... and matrix metalloproteinases suggests that matrix remodeling within the hypertrophic zones in Ctgf mutants is defective. The mutant phenotype also revealed a role for Ctgf in growth plate angiogenesis. Hypertrophic zones of Ctgf mutant growth plates are expanded, and endochondral ossification is impaired...
Journal Articles
Journal: Development
Development (1999) 126 (9): 1869–1878.
Published: 1 May 1999
... in these two screens overlap. However it is likely that there will be genes that are required for border cell migration that would not rescue a slbo mutant when over- expressed. One concern about genes identified based on the phenotype produced in mosaic clones is that the screen might identify...
Journal Articles
Journal: Development
Development (1999) 126 (6): 1235–1246.
Published: 15 March 1999
...Jarema Malicki; Wolfgang Driever ABSTRACT Mutations of the oko meduzy (ome) locus cause drastic neuronal patterning defect in the zebrafish retina. The precise, stratified appearance of the wild-type retina is absent in the mutants. Despite the lack of lamination, at least seven retinal cell types...
Journal Articles
Journal: Development
Development (1996) 123 (1): 241–254.
Published: 1 December 1996
... Mutations giving rise to anatomical defects in the inner ear have been isolated in a large scale screen for mutations causing visible abnormalities in the zebrafish embryo ( Haffter, P., Granato, M., Brand, M. et al. (1996) Development 123, 1-36). 58 mutants have been classified as having a primary ear...
Journal Articles
Journal Articles
Journal: Development
Development (1992) 115 (1): 133–142.
Published: 1 May 1992
... effect on the pattern of neural crest-derived pigment cells, and in homozygous mutant embryos by visible defects in craniofacial structures. Since both pigment cells and craniofacial structures are derived from the neural crest, we have examined the differentiation of other crest cell-derived structures...
Journal Articles
Journal Articles
Journal: Development
Development (1990) 110 (2): 529–537.
Published: 1 October 1990
... dysmyelination mutant myelin glia jimpy proteolipid protein gene oligodendrocyte canine development. Myelination is a developmentally controlled process whereby neuronal axons are enwrapped by a multilayer membrane sheath. In the central nervous system (CNS), this function is carried out...
Journal Articles
Journal: Development
Development (1989) 106 (1): 57–66.
Published: 1 May 1989
...Pat Simpson; Cathie Carteret A study of shaggy mutant clones on the notum reveals that a greater number of cells are diverted into the bristle pathway of differentiation and fewer cells remain to produce the epidermis, shaggy clones differentiate supernumerary microchaetae and macrochaetae...
Journal Articles
Journal Articles
Journal: Development
Development (1988) 102 (4): 721–734.
Published: 1 April 1988
..., there is a poleward expansion of the remaining pattern. Using anti-horseradish peroxidase staining, we show that the formation of the embryonic brain requires tll . A phenotypic and genetic study of other pattern mutants places the tll gene within the hierarchy of maternal and zygotic genes required for the formation...
Journal Articles
Journal: Development
Development (1988) 102 (2): 325–338.
Published: 1 February 1988
...) expression as markers for the body plan, we have studied the phenotype of pair-rule mutants prior to cell death. All these mutants alter the expression of en and Ubx; then-molecular phenotypes suggest a pathway whereby pair-rule gene functions construct metameric units. * Present address: Department...
Journal Articles
Journal: Development
Development (1987) 100 (2): 261–269.
Published: 1 June 1987
... were mapped to defined positions in the eye-antennal imaginal disc by transplanting abnormal regions of discs isolated from tuh-3 mutants into host mwh;e 4 larvae. These metamorphosed implants were removed and differentiated structures were identified. Of 211 successfully recovered implants, 157 gave...