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Keywords: Mutant
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Journal Articles
Journal: Development
Development (2021) 148 (24): dev199675.
Published: 24 December 2021
...Hussein A. Saud; Paul A. O'Neill; Yosuke Ono; Bas Verbruggen; Ronny Van Aerle; Jaebum Kim; Jae-Seong Lee; Brian C. Ring; Tetsuhiro Kudoh ABSTRACT Using the self-fertilizing mangrove killifish, we characterized two mutants, shorttail ( stl ) and balltail ( btl ). These mutants showed abnormalities...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155366.
Published: 9 January 2018
... nanog (maternal and zygotic null) mutant zebrafish embryos . Without functional Nanog, epiboly is severely affected, embryo axes do not form and massive cell death starts at the end of gastrulation. We show that three independent defects in MZ nanog mutants contribute to epiboly failure: yolk...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4280–4290.
Published: 15 November 2012
...Nikolaus Obholzer; Ian A. Swinburne; Evan Schwab; Alex V. Nechiporuk; Teresa Nicolson; Sean G. Megason Forward genetic screens in zebrafish have identified >9000 mutants, many of which are potential disease models. Most mutants remain molecularly uncharacterized because of the high cost, time...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2521–2531.
Published: 1 July 2007
... or western blot. The mutant esophagus morphologically resembles the trachea,with ectopic expression of Nkx2.1, a columnar, ciliated epithelium, and very few p63 + basal cells. By contrast, the abnormal foregut of Nkx2.1 -null embryos expresses elevated Sox2 and p63, suggesting reciprocal regulation of Sox2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 2955–2967.
Published: 1 July 2005
... phenotypes. Thirteen recessive mutations in 12 genes were discovered. In one mutant, ddl , the majority of RGCs fail to differentiate. Three of the mutations, vrt , late and tard , delay the orderly ingrowth of retinal axons into the tectum. Two alleles of drg disrupt the layer-specific targeting of retinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1699–1711.
Published: 1 April 2005
... studied as a paradigm of tissue pattern formation in plants. To elucidate the molecular mechanism controlling the vein patterning process,we previously isolated Arabidopsis mutants van1 to van7 , which show a discontinuous vein pattern. Here we report the phenotypic analysis of the van3 mutant in relation...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2779–2791.
Published: 15 June 2003
... and matrix metalloproteinases suggests that matrix remodeling within the hypertrophic zones in Ctgf mutants is defective. The mutant phenotype also revealed a role for Ctgf in growth plate angiogenesis. Hypertrophic zones of Ctgf mutant growth plates are expanded, and endochondral ossification is impaired...
Journal Articles
Journal: Development
Development (1986) 95 (1): 117–130.
Published: 1 June 1986
...S. K. Frost; L. G. Epp; S. J. Robinson The axanthic mutant in the Mexican axolotl ( Ambystoma mexicanum ) was analysed with respect to the differentiation of pigment cells. Transmission electron micrographs revealed the presence of melanophores and cells that are described as unpigmented...
Journal Articles
Journal: Development
Development (1986) 91 (1): 1–18.
Published: 1 February 1986
...M. J. Harris; D. M. Juriloff In normal mice the eyelids grow across the eye and fuse together during days 15 and 16 of gestation, and the mice are born with their eyes closed. In mutant lg M1 / lg M1 (lidgap-Miller) foetuses this growth and fusion does not occur and the mice are born...
Journal Articles
Journal: Development
Development (1985) 88 (1): 39–54.
Published: 1 August 1985
...Andrew J. Copp The relationship between timing of closure of the posterior neuropore (PNP) and development of spinal neural tube defects (NTD) has been studied in individual mutant curly tail mouse embryos maintained in culture. Moderate delay in PNP closure results in development of tail flexion...
Journal Articles
Journal: Development
Development (1985) 85 (1): 271–283.
Published: 1 February 1985
... that the mutant limb mesenchyme fails to transmit or respond to factor(s) produced by the ZPA. Copyright © 1985 by Company of Biologists 1985 12 9 1984 * Author's present address: Department of Anatomy and Biology as Applied to Medicine, The Middlesex Hospital Medical School, Cleveland Street...