... in skeletal muscle regeneration and, in the absence of eosinophil-secreted interleukin (IL) 4 and IL13, fibro-adipogenic progenitors fail to support muscle stem cell proliferation. However, the role of eosinophils in muscular dystrophy remains elusive. Although it has been shown that eosinophils are present...

... function is a hallmark of a number of conditions, ranging from developmental disorders to rhabdomyosarcoma and muscular dystrophies ( Emery, 2002 ). In the adult, acute muscle injury such as volumetric loss, late-onset muscle dystrophies, neuromuscular degenerative diseases, cachexia as well as aging...

... that whereas LanA acts in the follicle cells and muscle sheath to shape the egg, Wb is only required in the muscle sheath; however, analysis of a wb null allele will be required to validate this assertion. Several human muscular dystrophies are caused by mutations in Laminin or components...

..., and defects in its structure correlate with a subset of muscular dystrophies. Col22a1 encodes the MTJ component collagen XXII, the function of which remains unknown. Here, we have cloned and characterized the zebrafish col22a1 gene and conducted morpholino-based loss-of-function studies in developing embryos...

...Mario Pantoja; Karin A. Fischer; Nicholas Ieronimakis; Morayma Reyes; Hannele Ruohola-Baker Duchenne muscular dystrophy is a lethal genetic disease characterized by the loss of muscle integrity and function over time. Using Drosophila , we show that dystrophic muscle phenotypes can be significantly...

... myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. Proc. Natl. Acad. Sci. USA 99 , 15060 -15065. Carpenter, S. and Karpati, G. ( 1979 ). Duchenne muscular dystrophy: plasma membrane loss initiates muscle cell necrosis unless it is repaired. Brain 102 , 147 -161...

... and in the mature myotome and defects in its composition underlie certain forms of muscular dystrophy. A major component of this extracellular structure is the laminin polymer, which assembles into a resilient meshwork that protects the sarcolemma during contraction. Here we describe a zebrafish mutant, softy...

.... The DGC is crucial for muscle integrity as exemplified by the fact that mutations in components of the DGC cause muscular dystrophy ( Davies and Nowak,2006 ; Durbeej and Campbell,2002 ; Durbeej et al.,1998 ; Straub et al.,1997 ). Far less is known about the function of integrins in muscle. Integrins...

... of the human muscular dystrophies. Here, we show that one of these mutations, sapje , disrupts the zebrafish orthologue of the X-linked human Duchenne muscular dystrophy ( DMD ) gene. Mutations in this locus cause Duchenne or Becker muscular dystrophies in human patients and are thought to result...

...Michael J. Parsons; Isabel Campos; Elizabeth M. A. Hirst; Derek L. Stemple Muscular dystrophy is frequently caused by disruption of the dystrophin-glycoprotein complex (DGC), which links muscle cells to the extracellular matrix. Dystroglycan, a central component of the DGC, serves as a laminin...

... of myofibril contraction and the placement of new muscle attachments in functioning muscles. Finally, we draw some comparisons to vertebrate skin fragility diseases and muscular dystrophies. © 2000 by Company of Biologists 2000 Mechanobullous skin disease Skin Muscular dystrophy Nematode Skeletal...

... 2E). The present experiments were performed to determine if mutant chick embryos afflicted with hereditary muscular dystrophy would respond similarly to this experimental manipulation. Using the same criteria applied to our analysis of experimental normal embryos, our results demonstrated...