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Keywords: Msx2
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Journal Articles
Journal: Development
Development (2013) 140 (5): 1034–1044.
Published: 1 March 2013
... undifferentiated precursor cells located above the eye. Here, we demonstrate a role for Foxc1 in modulating the influence of Bmp signaling on the expression of Msx2 and the specification of these cells. Inactivation of Foxc1 results in a dramatic reduction in skull vault growth and causes an expansion of Msx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3577–3586.
Published: 1 November 2008
... cells (NCCs) that ultimately specifies cardiac NCC function for OFT development, but does not regulate NCC migration to the heart. We show that Pbx1 directly activates Pax3 , leading to repression of its target gene Msx2 in NCCs. Compound Msx2/Pbx1 -null embryos display significant rescue of cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 4937–4950.
Published: 15 November 2005
...Mamoru Ishii; Jun Han; Hai-Yun Yen; Henry M. Sucov; Yang Chai; Robert E. Maxson, Jr The neural crest is a multipotent, migratory cell population that contributes to a variety of tissues and organs during vertebrate embryogenesis. Here, we focus on the function of Msx1 and Msx2 , homeobox genes...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5153–5165.
Published: 15 October 2004
... transcriptional responses in different cell types. Here,we identify a BMP-responsive enhancer of Msx2 , an immediate early target of bone morphogenetic protein (BMP) signaling. We show that the BMP-responsive region of Msx2 consists of a core element, required generally for BMP-dependent expression, and ancillary...
Journal Articles
Journal: Development
Development (2003) 130 (24): 6131–6142.
Published: 15 December 2003
... such anomaly is familial calvarial foramina, persistent unossified areas within the skull vault. Mutations in MSX2 and TWIST are known to cause calvarial foramina in humans. Little is known of the cellular and developmental processes underlying this defect. Neither is it known whether MSX2 and TWIST function...
Journal Articles
Journal: Development
Development (2003) 130 (2): 379–389.
Published: 15 January 2003
...Liang Ma; Jian Liu; Tobey Wu; Maksim Plikus; Ting-Xin Jiang; Qun Bi; Yi-Hsin Liu; Sven Müller-Röver; Heiko Peters; John P. Sundberg; Rob Maxson; Richard L. Maas; Cheng-Ming Chuong Msx2 -deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4647–4660.
Published: 1 October 2002
.... 2002 Bone morphogenetic protein Cleft lip Chicken embryo Noggin Craniofacial Beads Programmed cell death Msx1 Msx2 Fgf8 Shh The basis for cleft lip is the failure of individual components of the upper embryonic face (facial prominences) to meet and fuse at the appropriate time...
Journal Articles
Journal: Development
Development (2002) 129 (2): 527–538.
Published: 15 January 2002
... does not occur. Downstream genes through which Pax3 regulates cardiac neural crest development are unknown. Here, using a combination of genetic and molecular approaches, we show that the deficiency of cardiac neural crest development in the Splotch mutant is caused by upregulation of Msx2 , a homeobox...
Journal Articles
Journal: Development
Development (2001) 128 (11): 2075–2084.
Published: 1 June 2001
... for a positive influence of FGFs on BMP gene expression, the physiological implication of FGFs in apoptosis appears to result from their requirement for the expression of genes of the apoptotic cascade. We have identified MSX2 and Snail as candidate genes associated with apoptosis the expression of which...