... are essential to rescue cilia in talpid 3 chicken mutants. We constitutively deleted these two exons to make a talpid3 –/– mouse. Mutant mouse embryos lack primary cilia and, like talpid 3 chicken embryos, have face and neural tube defects but also defects in left/right asymmetry. Conditional deletion in mouse...

... that developing sensory structures control morphogenesis of non-sensory structures( Chang et al., 2004 ). Mouse mutants support this concept. Mice lacking FGFR2b form otic vesicles that subsequently develop dysmorphologies initiating at EDS outgrowth and include failure of semicircular canal formation( Pirvola et...

... for processing and function. PLoS Genet. 1 , e53 . Heymer, J., Kuehn, M. and Rüther, U. ( 1997 ). The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness. Mech. Dev. 662 , 5 -11. Hirokawa, N., Tanaka, Y., Okada, Y. and Takeda, S...

... -/- mutants emphasizes the diversity of tendon tissues and represents the first molecular insight into the important process of tendon differentiation. * Author for correspondence (e-mail: [email protected] ) 15 5 2007 © 2007. 2007 Scleraxis Tendon Connective tissue Mouse mutant...

... progenitor Mouse mutant Fig. 2. Localization of Foxg1 -driven Cre expression and strategy for generating Fgf8 conditional knockouts. (A) X-gal staining of R26R lacZ/+ ;Foxg1 Cre/+ embryos at E9.5, E10.5 and E12.5. Top panels show whole-mount images and bottom panels show corresponding...

... Neurogenesis Proliferation Regionalization DNA-binding domains Paired domain Homeodomain Mouse mutant The transcription factor Pax6 is conserved from invertebrates to vertebrates and regulates key developmental processes in several organs throughout phylogeny ( Chi and Epstein,2002 ). In all...

...-mail: [email protected] ) 23 4 2003 © 2003. 2003 Fibroblast growth factor Otic Placode Inner ear Induction Mouse mutant The inner ear, which contains the sensory organs specialised for audition and balance, develops from placodal ectoderm located adjacent...

... of the diffusible mesodermal signals that pattern the pharyngeal endoderm. * Author for correspondence (e-mail: [email protected] ) 24 2 2003 © 2003. 2003 Retinoids Branchial arches Pharyngeal endoderm DiGeorge syndrome Hirschprung's disease Mouse mutant Conotruncal...

... of gastrulation ( Abu-Abed et al.,2001 ; Fujii et al.,1997 ; Niederreither et al.,1997 ; Niederreither et al.,1999 ; Sakai et al.,2001 ). Gastrulation Tail bud Cytochrome P450 Homeotic transformations Mouse mutant Retinoids Retinoic acid Teratogenesis Spina bifida Caudal regression Cyp26a1...

... are shifted anteriorly with respect to the segmental borders that form later ( Martinez-Arias and Lawrence, 1985 ; Lawrence, 1988 ). Cardiomyocyte differentiation Heart development Left-right patterning Mouse mutant Myocardium Raldh2 Retinaldehyde dehydrogenase Retinoids Tbx5 © 2001...

... as more severe than in the VAD quail embryos, we found that Lefty, Nodal and Pitx2 were expressed at normal levels on the left side of mouse mutant embryos. Thus, both animal models lead us to the conclusion that endogenous RA is not mandatory for setting up left side-specific expression of genes...

... 1999 by Company of Biologists 1999 Mouse mutant HoxA HoxD Limb bud Patterning Posterior limb identity Shh activation Growth and patterning of vertebrate limb buds is controlled by epithelial-mesenchymal interactions of two main signaling centers. Apical ectodermal ridge (AER...

... shaker-1 Mouse mutant Myosin VIIA Cochlea Hair cell Stereocilia Hearing Usher syndrome Very little is known about the molecular basis of sensory hair cell function or development, partly because the small number of hair cells in each inner ear makes a biochemical approach impractical. We...

... be to modulate Trk signalling ( Meakin and Shooter, 1992 ; Glass and Yancopoulos, 1993 ; Davies et al., 1994 ; Hantzopoulos et al., 1994 ; Verdi et al., 1994 ). trkB trkC mouse mutant inner ear vestibular ganglion cochlear ganglion hair cell target innervation © 1995 by Company...

... and to analyse their mutant phenotypes both in terms of effects on the expression patterns and activities of other genes and in terms of effects on body structure. In this paper, we examine the role of the kreisler gene. kreisler mouse mutant rhombomere cranial nerves Hox genes Krox-20 CRABP...

... illustrates the importance of generating different mutations at a given locus to elucidate fully the function of a particular gene during development. * Author for correspondence 30 06 1992 © 1993 by Company of Biologists 1993 N-myc heart development targeted mutagenesis mouse...

... sufficiently similar to justify the use of cultured embryos in subsequent experiments. * F.A.B. and A.S.W S. contributed equally to this study 26 06 1993 © 1991 by Company of Biologists 1991 neural tube morphogenesis mouse mutant embryo culture curvature curly tail ( ct...