... of RAB function in mammals comes from studies performed with cultured cells. However, the available mouse models have been instrumental in clarifying the function of several RAB proteins, including RAB3, RAB6, RAB8, RAB10 and RAB11, in a physiological context ( Homma et al., 2021 ). A previous study...

... AR signaling has been shown to be essential for prostatic initiation. However, the molecular mechanisms underlying AR-initiated mesenchymal-epithelial interactions in prostate development remain unclear. Here, using a newly generated mouse model, we have directly addressed the fate and role...

... branching morphogenesis and growth. Furthermore, ablation of Frs2 α alleles retarded prostatic tumor formation and progression in the autochthonous TRAMP mouse model of prostate cancer. The data demonstrate that FRS2α is important for prostatic development and growth, and imply that aberrant activation...

... (e-mail: [email protected] 23 9 2002 ©2002. 2002 PKD mouse models zebrafish Nek kinase The rapid progress in characterization of mammalian genome sequence will facilitate the use of mouse mutants for understanding gene function, and for investigating how...