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Keywords: Mouse models
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Journal Articles
Journal: Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
... AR signaling has been shown to be essential for prostatic initiation. However, the molecular mechanisms underlying AR-initiated mesenchymal-epithelial interactions in prostate development remain unclear. Here, using a newly generated mouse model, we have directly addressed the fate and role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 775–784.
Published: 15 February 2008
... branching morphogenesis and growth. Furthermore, ablation of Frs2 α alleles retarded prostatic tumor formation and progression in the autochthonous TRAMP mouse model of prostate cancer. The data demonstrate that FRS2α is important for prostatic development and growth, and imply that aberrant activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (24): 5839–5846.
Published: 15 December 2002
... to maintain differentiated epithelial cell form and function; this is likely to involve multiple cell signaling pathways and cell structures, including those required for cell adhesion, maintainance of the cytoskeleton and epithelial cell polarity. PKD mouse models zebrafish Nek kinase ©2002...