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Keywords: Motoneurons
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Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
... the number of Olig2 + motoneuron progenitors and Hb9 + motoneurons without a significant effect on cell survival or proliferation. These effects were a specific and direct consequence of Shh reduction in the mesoderm. In addition, grafting notochords in a basal but not apical location, vis-à-vis the tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 139–150.
Published: 01 January 2017
...Christian Hessinger; Gerhard M. Technau; Ana Rogulja-Ortmann Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord and to control motoneuronal targeting in several species. However, the mechanisms controlling axial diversification of muscle innervation patterns...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 2027–2038.
Published: 01 May 2013
...Myungin Baek; Jonathan Enriquez; Richard S. Mann Adult Drosophila walk using six multi-jointed legs, each controlled by ∼50 leg motoneurons (MNs). Although MNs have stereotyped morphologies, little is known about how they are specified. Here, we describe the function of Hox genes and homothorax...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1583–1593.
Published: 01 April 2013
...-59 expression in mice is restricted to specific pools of neurons, in particular motoneurons (MNs), and progressively increases from embryonic day 12.5 (E12.5) until the first postnatal days. We generated a Clipr-59 knockout mouse model that presents perinatal lethality due to respiratory defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5429–5439.
Published: 15 December 2011
.... 19 10 2011 © 2011. Ciona Ephrin FGF Motoneurons Neural tube Notch Central pattern generators (CPGs) are discrete neuronal networks that drive rhythmic motor behaviors ( Marder and Bucher, 2001 ; Wilson and Maden, 2005 ). Spinal cord CPGs control the swimming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (5): 995–1004.
Published: 01 March 2011
... of putative interneuron markers Dmbx and Vsx results in ectopic interneuron-like cells at the expense of motoneurons. Furthermore, by perturbing upstream signaling events, we can change the transcription factor expression profile and subsequent identity of the different precursors. Perturbation of FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1205–1213.
Published: 01 April 2010
... and humans have established that the homeobox transcription factor gene PHOX2A is required for midbrain motoneuron development. We probed, in forced expression experiments, the capacity of PHOX2A to generate a spatially organized midbrain OMC. We found that exogenous Phox2a delivery to embryonic chick...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3435–3445.
Published: 15 October 2008
... to segment diversity remain largely unknown. We report here that the Hox genes Ultrabithorax ( Ubx ) and Antennapedia ( Antp ) regulate segment-specific survival of differentiated motoneurons in the ventral nerve cord of Drosophila embryos. We show that Ubx is required to activate segment-specific apoptosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 729–741.
Published: 15 February 2008
...-institute.org ) 3 12 2007 © 2008. 2008 Cut-like Cux Spinal cord Neurogenesis Interneurons Motoneurons Neurod1 p27 Kip1 Cell cycle Mouse Neurogenesis requires the complex integration of neural progenitor proliferation, cell-cycle exit, migration and differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (10): 1911–1920.
Published: 15 May 2007
... spinal cord precursors called pMN cells produce mostly motoneurons and oligodendrocytes, but recent lineage-marking experiments reveal that they also make astrocytes, ependymal cells and interneurons. Our own clonal analysis of pMN cells in zebrafish showed that some produce a primary motoneuron and KA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 65–75.
Published: 01 January 2007
... together with exclusion from the motoneuron progenitor domain, are the result of the activity of key transcription factors responsible for patterning the neural tube. Smad3-mediated TGFβ activity promotes cell-cycle exit and neurogenesis by inhibiting the expression of Id proteins, and activating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 581–590.
Published: 15 February 2006
...Sen Wu; Yuanyuan Wu; Mario R. Capecchi Olig gene expression is proposed to mark the common progenitors of motoneurons and oligodendrocytes. In an attempt to further dissect the in vivo lineage relationships between motoneurons and oligodendrocytes, we used a conditional cell-ablation approach...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (20): 4483–4495.
Published: 15 October 2005
... which molecules mediate this effect in vivo. We show that Slit and Robo proteins are candidate motor axon guidance molecules, as Robo proteins are expressed by cranial motoneurons, and Slit proteins are expressed by the tissues that delimit motor axon trajectories, i.e. the floor plate and the rhombic...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2463–2474.
Published: 15 May 2005
... congenital heart defects, and demonstrated a critical requirement for Tbx20 in valve formation. Finally, an intermediate knockdown revealed a role for Tbx20 in motoneuron development, specifically in the regulation of the transcription factors Isl2 and Hb9 , which are important for terminal differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1935–1949.
Published: 15 April 2005
... describe the role of the Aristaless/Arx homolog alr-1 in C. elegans . We show that alr-1 acts in a pathway with the LIM1 ortholog lin-11 to regulate the development of a subset of chemosensory neurons. Moreover, we demonstrate that the differentiation of a GABAergic motoneuron subtype is affected in alr-1...
Journal Articles
Journal: Development
Development (2005) 132 (7): 1611–1621.
Published: 01 April 2005
.... Here, we have investigated the functions of local RA synthesis in the process of motoneuron specification and early differentiation using a conditional knockout strategy that ablates the function of the retinaldehyde dehydrogenase 2 (Raldh2) synthesizing enzyme essentially in brachial motoneurons...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5959–5969.
Published: 01 December 2004
... that any one precursor population produces and the mechanisms that diversify cell fate are unknown. By fate mapping and clonal analysis in zebrafish, we show that individual ventral precursor cells that express olig2 can form motoneurons, interneurons and oligodendrocytes. However, olig2 + precursors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (21): 5429–5439.
Published: 01 November 2004
...Sarah J. Certel; Stefan Thor In both vertebrates and invertebrates, members of the LIM-homeodomain(LIM-HD) family of transcription factors act in combinatorial codes to specify motoneuron subclass identities. In the developing Drosophila embryo,the LIM-HD factors Islet (Tailup) and Lim3, specify...
Journal Articles
Journal: Development
Development (2004) 131 (21): 5233–5242.
Published: 01 November 2004
... of the genetic network of transcription factors that specifies neuronal fates in Drosophila . Nkx6 collaborates with the homeodomain protein Hb9 to specify ventrally projecting motoneuron fate and to repress dorsally projecting motoneuron fate. While Nkx6 acts in parallel with hb9 to regulate motoneuron fate, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (4): 891–902.
Published: 15 February 2004
...Katharine E. Lewis; Judith S. Eisen We provide the first analysis of how a segmentally reiterated pattern of neurons is specified along the anteroposterior axis of the vertebrate spinal cord by investigating how zebrafish primary motoneurons are patterned. Two identified primary motoneuron subtypes...