.... Despite this difference in the arrest phase, both arrests depend on the same Mos-MAPK (mitogen-activated protein kinase) pathway, indicating that the difference relies on particular downstream effectors. Immediately downstream of MAPK, Rsk (p90 ribosomal S6 kinase, p90 Rsk ) is required for the frog meta...

...Marion Peter; Jean-Claude Labbé; Marcel Dorée; Elisabeth Mandart The resumption of meiosis in Xenopus arrested oocytes is triggered by progesterone, which leads to polyadenylation and translation of Mos mRNA, then activation of MAPK pathway. While Mos protein kinase has been reported...

... provides a suitable and robust approach to study the function of dormant maternal mRNAs. Mos (originally known as c- mos ) and tissue plasminogen activator (tPA, Plat ) mRNAs are dormant maternal mRNAs that are recruited during oocyte maturation; translation of Mos mRNA results in the activation of MAP...

... not decrease after the first cycle and therefore did not explain the lack of cdc2 tyrosine phosphorylation in, nor the rapidity of, cycles 2-12. Furthermore, there was no evidence for a wee1/myt1 inhibitor in cycles 2-12. We examined the role of Mos in the first cycle because it is present during the first 20...

...Yuji Hirao; John J. Eppig ABSTRACT Oocytes of almost all vertebrates become arrested at metaphase II to await fertilization. Arrest is achieved with the participation of a protein complex known as cytostatic factor (CSF) that stabilizes histone H1 kinase activity. MOS and mitogen-activated protein...

...Marie-Hélène Verlhac; Jacek Z. Kubiak; Michèle Weber; Gérard Géraud; William H. Colledge; Martin J. Evans; Bernard Maro ABSTRACT Mos is normally expressed during oocyte meiotic maturation in vertebrates. However, apart from its cytostatic factor (CSF) activity, its precise role during mouse meiosis...