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Keywords: Morphogens
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (3): dev202128.
Published: 12 February 2024
...Thamarailingam Athilingam; Ashwin V. S. Nelanuthala; Catriona Breen; Narain Karedla; Marco Fritzsche; Thorsten Wohland; Timothy E. Saunders ABSTRACT Morphogen gradients provide essential positional information to gene networks through their spatially heterogeneous distribution, yet how they form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (18): dev201868.
Published: 28 September 2023
... clones are cell-autonomous, consistent with a morphogen function. Shifts in expression of WntA and fz2 in WntA crispant pupae show that they are under positive and negative feedback, respectively. Fz1 is required for Wnt-independent planar cell polarity in the wing epithelium. Fz3 and Fz4 show phenotypes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (23): dev199842.
Published: 7 December 2022
...David G. Míguez; Antonella Iannini; Diana García-Morales; Fernando Casares ABSTRACT Morphogens of the Hh family trigger gene expression changes in receiving cells in a concentration-dependent manner to regulate their identity, proliferation, death or metabolism, depending on the tissue or organ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (15): dev200712.
Published: 29 July 2022
... driving their epithelial-to-mesenchymal transition. Neural crest EMT Morphogens Cadherins Transcription factors Post-translational modifications School of Veterinary Medicine, University of California, Davis http://dx.doi.org/10.13039/100009751 National Science Foundation...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev186395.
Published: 21 December 2020
...Elodie Prince; Julien Marcetteau; Pascal P. Thérond ABSTRACT Members of the Hedgehog family of morphogens mediate the intercellular communication necessary for the organisation and development of many animal tissues. They are modified by various lipid adducts, rendering them insoluble...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev190553.
Published: 29 October 2020
..., just 0.004% of the number of possible diffusion-driven instability networks. Together, these studies articulate the principles of multi-morphogen RD patterning and demonstrate the utility of perturbation analysis for constraining RD systems. This article has an associated ‘ The people behind the papers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev177709.
Published: 20 December 2019
...Daniel Čapek; Patrick Müller ABSTRACT In order to contribute to the appropriate tissues during development, cells need to know their position within the embryo. This positional information is conveyed by gradients of signaling molecules, termed morphogens, that are produced in specific regions...
Journal Articles
Journal: Development
Development (2019) 146 (9): dev169367.
Published: 9 May 2019
... Wnt and Dpp as candidate morphogens, accurately replicates these complex crispant phenotypes. These results provide new insight into the function of Dll as a potential activator of eyespot development, scale growth and melanization, and suggest that the tuning of Dll expression levels can generate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2745–2749.
Published: 15 July 2014
... ( neuroman@umich.edu ) Competing interests The author declares no competing financial interest. © 2014. Published by The Company of Biologists Ltd 2014 Regeneration Reprogramming Morphogenesis Self-organization Morphogens Growth control Recent advances in regeneration research...
Journal Articles
Journal: Development
Development (2013) 140 (20): 4119–4124.
Published: 15 October 2013
...Angelike Stathopoulos; Dagmar Iber Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source, and various modes of transport and interpretation have been suggested for morphogens. The recent EMBO Workshop on ‘Morphogen gradients’, which took place...
Journal Articles
Journal: Development
Development (2012) 139 (23): 4311–4319.
Published: 1 December 2012
...), is of particular relevance for embryonic development. In this Primer, we describe how LRPs constitute central pathways that modulate morphogen presentation to target tissues and cellular signal reception, and how LRP dysfunction leads to developmental disturbances in many species. * Author for correspondence...
Journal Articles
Journal: Development
Development (2008) 135 (24): 4003–4013.
Published: 15 December 2008
...Gerald Schwank; Simon Restrepo; Konrad Basler Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp)regulates cell proliferation. Contrary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (4): 627–636.
Published: 15 February 2008
... activator of Dll and dac . Because Wg is a diffusible morphogen, we also tested the idea that high levels of Wg signaling would be required to activate Dll , whereas lower levels would be sufficient for dac activation. Our previous experiments demonstrate that both genes are activated in ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4843–4856.
Published: 1 October 2004
...Karsten Kruse; Periklis Pantazis; Tobias Bollenbach; Frank Jülicher; Marcos González-Gaitán Developing cells acquire positional information by reading the graded distribution of morphogens. In Drosophila , the Dpp morphogen forms a long-range concentration gradient by spreading from a restricted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1990) 110 (2): 435–443.
Published: 1 October 1990
... and to cause the differentiation of two erythroleukemia cell lines. Our results, along with recent data from other laboratories, indicate that these molecules may also act in early development in the formation of the mesoderm. * Present Address: Furusawa Morphogenes Project, 5-9-6 Tohkohdat, Tsukuba 300...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 141–148.
Published: 1 April 1989
... by Company of Biologists 1989 Xenopus laevis mesoderm induction mesoderm-inducing factors fibroblast growth factor fibroblast growth factor receptor transforming growth factor beta competence morphogens Work in experimental embryology has given us a fairly detailed picture...