... averaging of cell growth, preserving robust organ morphogenesis, whereas correlated growth fluctuations impair averaging. * Author for correspondence ( [email protected] ) Handling Editor: Dominique Bergmann Competing interests The authors declare no competing or financial interests...

... flux influence DTC elaboration. We propose a ‘hitch and tow’ aspect of organ-level dynamics that contributes to cellular morphogenesis, whereby germline flux drags the flexible DTC cell cortex away from its stationary cell body. More broadly, we speculate that this mechanism may contribute to cell...

..., leading to a short ventricle and outflow tract abnormalities. Heart development Second heart field Morphogenesis Congenital heart disease FGF signaling National Institutes of Health R35 HL135778 New York State Department of Health http://dx.doi.org/10.13039/100004856...

...Jyoti P. Satta; Riitta Lindström; Satu-Marja Myllymäki; Qiang Lan; Ewelina Trela; Renata Prunskaite-Hyyryläinen; Beata Kaczyńska; Maria Voutilainen; Satu Kuure; Seppo J. Vainio; Marja L. Mikkola ABSTRACT Branching morphogenesis is a characteristic feature of many essential organs, such as the lung...

... mechanisms. Finally, I discuss how these advances position regeneration as a more dynamic and variable process with expanded possibilities for morphogenesis compared with development. Collectively, these insights into mechanisms that orchestrate morphogenesis may reshape our understanding of the evolution...

... of their simultaneous growth and mechanical interactions are still unclear. Our study investigates how differential growth, tissue biophysical properties and mechanical interactions affect embryonic morphogenesis during axial extension using a 2D multi-tissue continuum-based mathematical model. Our model captures...

... and enrichment for actin along the baso-apical axis were dependent on CM-Wnts. Thus, CM-Wnts regulate cellular behaviors during calvarial morphogenesis for efficient apical expansion of calvarial osteoblasts. These findings also offer potential insights into the etiologies of calvarial dysplasias...

...://www.biologists.com/user-licence-1-1/ Highlighted Article: Heterogeneities in cell mechanics, growth, function and identity contribute to buckling in clavata mutant shoot apices. WUSCHEL CLAVATA Heterogeneities Morphogenesis Mechanics Buckling Arabidopsis École Normale Supérieure...

... a mechanism involving FGFR/ERK attenuation. Altogether, our results demonstrate no role for BMP4/SMAD4 in the first lineage decisions during mouse development. Rather, multi-pathway signaling among embryonic and extra-embryonic cell types drives epiblast morphogenesis postimplantation. References...

...Tejasvinee Atul Mody; Alexander Rolle; Nico Stucki; Fabian Roll; Ulrich Bauer; Kay Schneitz ABSTRACT Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question...

... organisms. In contrast, the physical mechanisms that shape cells and tissues have only recently started to emerge, in part thanks to new quantitative in vivo measurements of the physical quantities guiding morphogenesis. These data, combined with indirect inferences of physical characteristics, are starting...

...Guy B. Blanchard; Elena Scarpa; Leila Muresan; Bénédicte Sanson ABSTRACT The planar orientation of cell division (OCD) is important for epithelial morphogenesis and homeostasis. Here, we ask how mechanics and antero-posterior (AP) patterning combine to influence the first divisions after...

...Vanessa Barone; Antonio Tagua; Jesus Á. Andrés-San Román; Amro Hamdoun; Juan Garrido-García; Deirdre C. Lyons; Luis M. Escudero ABSTRACT Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own...

..., tissue folding is a crucial process that relies on a combination of local and tissue-wide mechanical forces. Here, we investigate the contribution of cell proliferation to epithelial morphogenesis using the Drosophila leg tarsal folds as a model. We reveal that tissue-wide compression forces generated...

... morphogenesis. * Author for correspondence ( [email protected] ) Handling Editor: Steve Wilson Competing interests The authors declare no competing or financial interests. 7 3 2023 12 1 2024 © 2024. Published by The Company of Biologists Ltd 2024 This is an Open...

... cells (LPCs) Morphogenesis Biliary network Local injury Novo Nordisk Fonden http://dx.doi.org/10.13039/501100009708 NNF19OC0058327 NNF17CC0026756 NNF17OC0031204 National Institute of Genetics http://dx.doi.org/10.13039/501100010462 13A2018 Danmarks...

... of simulations where these cell properties and behaviors were activated homogeneously over space and at the same time the blastula grew by cell division. We tested a wide range of values for these parameters and we considered as biologically relevant the intervals in which morphogenesis occurred without...

...Panagiotis Oikonomou; Helena C. Cirne; Nandan L. Nerurkar ABSTRACT Although mechanical and biochemical descriptions of development are each essential, integration of upstream morphogenic cues with downstream tissue mechanics remains understudied during vertebrate morphogenesis. Here, we developed...

... cell differentiation. Our study demonstrates how these morphogens activate a combination of downstream pathways to direct cardiac morphogenesis. Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 SE2016/7-3 OL 653/3-1 KR 3985/12-1 SE2016/13-1 SE2016/10-1...

... local alignment search tool . J. Mol. Biol. 215 , 403 - 410 . 10.1016/S0022-2836(05)80360-2 Axelrod , J. D. and Mcneill , H. ( 2002 ). Coupling planar cell polarity signaling to morphogenesis . Sci. World J. 2 , 434 - 454 . 10.1100/tsw.2002.105 Basta , L. P...