... the telencephalic vesicle but undergo massive apoptosis resulting in their complete depletion at mid-corticogenesis. Here, we investigated the consequences of such a CR depletion on dorsal cortex lamination and hippocampal morphogenesis. We found that preplate splitting normally occurs in Gmnc −/− mutants...

... molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of anteroposterior axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled ex vivo , and that morphogenesis of individual tissues results from distinct morphogen...

... elongation. Interestingly, one innexin exhibited specific expression in intestinal cells. Our findings provide insights into how embryonic body wall muscles coordinate their activity and how interconnected tissues ensure proper morphogenesis. * Present address: MRC-LMB, Francis Crick Avenue...

... organizer formation. Actomyosin fibers Hydra regeneration Mechanochemical feedback Morphogenesis Topological defects European Research Council http://dx.doi.org/10.13039/100010663 819174 National Science Foundation http://dx.doi.org/10.13039/100000001 NSF-PHY-2309135...

.... , Huisken , J. and Bagnat , M. ( 2014 ). Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling . Development 141 , 1110 - 1119 . 10.1242/dev.100313 Andrew , D. J. and Ewald , A. J. ( 2010 ). Morphogenesis...

...-mediated auxin signalling machineries in Arabidopsis and Capsella reveals conserved functions in Brassicaceae with distinct fruit shapes. Gynoecium Fruit Auxin Polarity Morphogenesis Signalling John Innes Foundation http://dx.doi.org/10.13039/501100004034 Gatsby...

... removal of dorsal progenitors in the zebrafish tailbud using multiphoton ablation. This led to a proportional reduction in the length of the spinal cord and paraxial mesoderm in the tail, revealing a capacity for the regulation of tissue morphogenesis during tail formation. Following analysis of cell...

... constriction forces into lateral cell elongation and tissue folding. Here, we have investigated embryonic morphogenesis in anillin knockdown ( scra RNAi) embryos, where basal cell membranes fail to form and therefore cells can lose cytoplasmic volume through their basal side. Surprisingly, the mesoderm...

... averaging of cell growth, preserving robust organ morphogenesis, whereas correlated growth fluctuations impair averaging. * Author for correspondence ( [email protected] ) Handling Editor: Dominique Bergmann Competing interests The authors declare no competing or financial interests...

... flux influence DTC elaboration. We propose a ‘hitch and tow’ aspect of organ-level dynamics that contributes to cellular morphogenesis, whereby germline flux drags the flexible DTC cell cortex away from its stationary cell body. More broadly, we speculate that this mechanism may contribute to cell...

... ). To more comprehensively characterize how loss of gata6 affects heart morphogenesis, we crossed Tg(myl7:GFP); gata6 +/− adults, and stained mutant and sibling hearts for the cell membrane antigen Zn-5 (Alcama). On average, the surface area of CMs in the gata6 −/− atrium was significantly increased...

...Jyoti P. Satta; Riitta Lindström; Satu-Marja Myllymäki; Qiang Lan; Ewelina Trela; Renata Prunskaite-Hyyryläinen; Beata Kaczyńska; Maria Voutilainen; Satu Kuure; Seppo J. Vainio; Marja L. Mikkola ABSTRACT Branching morphogenesis is a characteristic feature of many essential organs, such as the lung...

... mechanisms. Finally, I discuss how these advances position regeneration as a more dynamic and variable process with expanded possibilities for morphogenesis compared with development. Collectively, these insights into mechanisms that orchestrate morphogenesis may reshape our understanding of the evolution...

... of their simultaneous growth and mechanical interactions are still unclear. Our study investigates how differential growth, tissue biophysical properties and mechanical interactions affect embryonic morphogenesis during axial extension using a 2D multi-tissue continuum-based mathematical model. Our model captures...

... and enrichment for actin along the baso-apical axis were dependent on CM-Wnts. Thus, CM-Wnts regulate cellular behaviors during calvarial morphogenesis for efficient apical expansion of calvarial osteoblasts. These findings also offer potential insights into the etiologies of calvarial dysplasias...

...-Kierzkowska , A.-L. , Kierzkowski , D. , Bassel , G. W. , Schüpbach , T. , Tauriello , G. , Bajpai , N. , Strauss , S. , Weber , A. , Kiss , A. et al. ( 2015 ). MorphoGraphX: A platform for quantifying morphogenesis in 4D . eLife 4 , 05864 . 10.7554/eLife.05864...

... a mechanism involving FGFR/ERK attenuation. Altogether, our results demonstrate no role for BMP4/SMAD4 in the first lineage decisions during mouse development. Rather, multi-pathway signaling among embryonic and extra-embryonic cell types drives epiblast morphogenesis postimplantation. * Present...

...Tejasvinee Atul Mody; Alexander Rolle; Nico Stucki; Fabian Roll; Ulrich Bauer; Kay Schneitz ABSTRACT Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question...

... organisms. In contrast, the physical mechanisms that shape cells and tissues have only recently started to emerge, in part thanks to new quantitative in vivo measurements of the physical quantities guiding morphogenesis. These data, combined with indirect inferences of physical characteristics, are starting...

...Guy B. Blanchard; Elena Scarpa; Leila Muresan; Bénédicte Sanson ABSTRACT The planar orientation of cell division (OCD) is important for epithelial morphogenesis and homeostasis. Here, we ask how mechanics and antero-posterior (AP) patterning combine to influence the first divisions after...