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Keywords: Morphogen
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200295.
Published: 16 May 2022
...Hyung Chul Lee; Cato Hastings; Nidia M. M. Oliveira; Rubén Pérez-Carrasco; Karen M. Page; Lewis Wolpert; Claudio D. Stern ABSTRACT In many developing and regenerating systems, tissue pattern is established through gradients of informative morphogens, but we know little about how cells interpret...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
...Shari Carmon; Felix Jonas; Naama Barkai; Eyal D. Schejter; Ben-Zion Shilo ABSTRACT Morphogen gradients are known to subdivide a naive cell field into distinct zones of gene expression. Here, we examine whether morphogens can also induce a graded response within such domains. To this end, we explore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199867.
Published: 4 October 2021
... exquisitely sensitive to the precise amplitude of Hh signaling. Even small changes in signaling strength can cause birth defects in mice and humans ( Nieuwenhuis and Hui, 2005 ). Hh ligands are considered to be classical morphogens: secreted molecules that direct cell-fate choices in a dose-dependent manner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196113.
Published: 20 January 2021
...Jihyun Irizarry; Angelike Stathopoulos ABSTRACT Morphogen concentration changes in space as well as over time during development. However, how these dynamics are interpreted by cells to specify fate is not well understood. Here, we focus on two morphogens: the maternal transcription factors Bicoid...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... in development and disease. Cholesterol Hedgehog signaling Morphogen Patched Primary cilium Smoothened Secreted hedgehog (HH) ligands are paracrine signaling factors that mediate communication between cells over distances as large as several hundred microns ( Lewis et al., 2001 ). The first...
Journal Articles
Journal: Development
Development (2019) 146 (2): dev159343.
Published: 16 January 2019
...-plate cells stretch along the dorsoventral axis of the developing spinal cord and provide a source of Wnt ligands for the proliferation of dorsal ependymal cells. Wnt Morphogen Spinal cord Roof plate Neural stem cell Regeneration Mouse During embryogenesis and homeostasis, secreted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev167338.
Published: 19 November 2018
... function in regulating the pattern of bone morphogenetic protein activity in cells, wings and embryos during Drosophila development. Glycosylation Bone morphogenetic protein Short gastrulation Chordin Morphogen Drosophila Glycosylation of secreted proteins in multicellular organisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
..., a transcription factor that patterns the Drosophila dorsal-ventral axis, accumulates at the embryo ventral midline. Here, model-guided experiments show that the inhibitor Cactus shuttles Dorsal to the ventral side. Morphogen Tissue patterning Mathematical modeling Dorsal Cactus Shuttling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3612–3624.
Published: 1 October 2017
...William J. Bodeen; Suresh Marada; Ashley Truong; Stacey K. Ogden During development, extracellular cues guiding cell fate determination are provided by morphogens. One mechanism by which morphogens are proposed to traverse extracellular space is by traveling along specialized filopodia called...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2691–2695.
Published: 1 August 2016
... 2016. Published by The Company of Biologists Ltd 2016 Summary: This Meeting Review summarises the recent RIKEN-CDB Symposium 'Size in Development: Growth, Shape and Allometry', highlighting recent advances and open questions in the field. Hippo pathway Growth control Morphogen...
Journal Articles
Journal: Development
Development (2015) 142 (21): 3781–3790.
Published: 1 November 2015
... roles are substrates of sumoylation ( Geiss-Friedlander and Melchior, 2007 ; Nie et al., 2009 ). It has been reported that sumoylation of Medea (Med), an intracellular transducer of the Drosophila morphogen Decapentaplegic (Dpp), triggers Med nuclear export and, therefore, restricts the range of Dpp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2150–2156.
Published: 15 May 2014
...Inna Averbukh; Danny Ben-Zvi; Siddhartha Mishra; Naama Barkai Morphogen gradients guide the patterning of tissues and organs during the development of multicellular organisms. In many cases, morphogen signaling is also required for tissue growth. The consequences of this interplay between growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1884–1893.
Published: 1 May 2014
...Ortrud Wartlick; Frank Jülicher; Marcos Gonzalez-Gaitan During morphogenesis, organs grow to stereotyped sizes, but growth control mechanisms are poorly understood. Here, we measured the signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 729–736.
Published: 15 February 2014
... mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests...
Journal Articles
Journal: Development
Development (2013) 140 (24): 4830–4843.
Published: 15 December 2013
... morphogenetic proteins Mathematical modeling Morphogen Pattern formation Scale invariance Turing Fig. 8. Pentagone- and Dally-mediated regulation of Dpp signaling produces active scaling by an ER feedback mechanism. (A) Schematic showing expander-repressor regulation of modulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1621–1638.
Published: 15 April 2013
...Patrick Müller; Katherine W. Rogers; Shuizi R. Yu; Michael Brand; Alexander F. Schier The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under...
Journal Articles
Journal: Development
Development (2013) 140 (7): 1467–1474.
Published: 1 April 2013
...Samuel Tozer; Gwenvael Le Dréau; Elisa Marti; James Briscoe The conventional explanation for how a morphogen patterns a tissue holds that cells interpret different concentrations of an extrinsic ligand by producing corresponding levels of intracellular signalling activity, which in turn regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4162–4171.
Published: 15 November 2012
.../STAT activation specifies three distinct anterior follicular cell fates, suggesting that Upd is a morphogen in this system. Consistent with the JAK/STAT activation pattern in the vitellarium, Upd forms a concentration gradient on the apical surface of the follicular epithelium with a peak at its source...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3168–3179.
Published: 1 September 2012
...Katie L. Ayers; Rana Mteirek; Alexandra Cervantes; Laurence Lavenant-Staccini; Pascal P. Thérond; Armel Gallet During development, secreted morphogens, such as Hedgehog (Hh), control cell fate and proliferation. Precise sensing of morphogen levels and dynamic cellular responses are required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (15): 2814–2820.
Published: 1 August 2012
... of mutants and points to several unanswered questions related to the dynamic interaction of the EGFR and Notch pathways. (1) (2) (3) (4) (5) (6) In this equation, ϕ 1 is the ratio of the size of the domain and the characteristic length scale of morphogen...