...Londen C. Johnson; An A. Vo; John C. Clancy; Krista M. Myles; Murugesan Pooranachithra; Joseph Aguilera; Max T. Levenson; Chloe Wohlenberg; Andreas Rechtsteiner; James Matthew Ragle; Andrew D. Chisholm; Jordan D. Ward ABSTRACT Nematode molting is a remarkable process where animals must repeatedly...

...Eileen Krüger; Wilson Mena; Eleanor C. Lahr; Erik C. Johnson; John Ewer Insect growth is punctuated by molts, during which the animal produces a new exoskeleton. The molt culminates in ecdysis, an ordered sequence of behaviors that causes the old cuticle to be shed. This sequence is activated...

... the formation of precocious adult alae in a lin-41 mutant background, suggesting that MAB-10 does not specifically act to control genes required for exit from the molting cycle and seam cell exit from the cell cycle, but more likely acts as a general enhancer of LIN-29 activity. EGR and NAB proteins...

... to promote terminal differentiation of the hypodermis and the cessation of molting in C. elegans . Loss of mir-84 exacerbates phenotypes caused by mutations in let-7, whereas increased expression of mir-84 suppresses a let-7 null allele. Adults with reduced levels of mir-84 and let-7 express genes...

... an oxygenase-like protein with a Rieske electron carrier domain, from the silkworm Bombyx mori and the fruitfly Drosophila melanogaster. nvd is expressed specifically in tissues that synthesize ecdysone, such as the PG. We also show that loss of nvd function in the PG causes arrest of both molting and growth...

...M. Wayne Davis; Andrew J. Birnie; Aubrey C. Chan; Antony P. Page; Erik M. Jorgensen Molting is required for progression between larval stages in the life cycle of nematodes. We have identified four mutant alleles of a Caenorhabditis elegans metalloprotease gene, nas-37 , that cause incomplete...

...Julie Gates; Geanette Lam; José A. Ortiz; Régine Losson; Carl S. Thummel Pulses of the steroid hormone ecdysone trigger the major developmental transitions in Drosophila , including molting and puparium formation. The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer...

...Jae H. Park; Andrew J. Schroeder; Charlotte Helfrich-Förster; F. Rob Jackson; John Ewer Insect growth and metamorphosis is punctuated by molts, during which a new cuticle is produced. Every molt culminates in ecdysis, the shedding of the remains of the old cuticle. Both the timing of ecdysis...

... βFTZ-F1 expression in the wild type. The resulting larvae are not able to molt, but this activity is rescued again by forced expression of βFTZ-F1, allowing progression to the next larval instar stage. On the other hand, premature expression of βFTZ-F1 in wild-type larvae at mid-first instar or mid...

...Tong-Ruei Li; Michael Bender ABSTRACT In Drosophila , pulses of the steroid hormone ecdysone trigger larval molting and metamorphosis and coordinate aspects of embryonic development and adult reproduction. At each of these developmental stages, the ecdysone signal is thought to act through...

..., which encodes adrenodoxin reductase (AR). In mammals, AR plays a key role in the synthesis of all steroid hormones. Null mutants of dare undergo developmental arrest during the second larval instar or at the second larval molt, and dare mutants of intermediate severity are delayed in pupariation...

... density lipoprotein receptor family is also essential for growth and development of this nematode. The mutations confer a striking defect, an inability to shed and degrade all of the old cuticle at each of the larval molts. The mutations also cause an arrest of growth usually at the molt from the third...

... used imprecise excision of a P element to create EcR deletion mutants that remove the EcR-B promoter and therefore should lack EcR-B1 and EcR-B2 expression but retain EcR-A expression. Most of these EcR-B mutant animals show defects in larval molting, arresting at the boundaries between the three...

... and their precursors. Inhibition of the gene encoding CHR3 results in several larval defects associated with abnormal epidermal cell function, including molting and body size regulation, suggesting that CHR3 is an essential epidermal factor required for proper postembryonic development. * Author...