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Keywords: Modeling
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Journal Articles
Journal: Development
Development (2019) 146 (14): dev177261.
Published: 19 July 2019
... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...
Journal Articles
Journal: Development
Development (2017) 144 (21): 3855–3866.
Published: 1 November 2017
... and biologists use the term ‘precision' to facilitate interactions using a common language. We also highlight selected examples in which the coupling of mathematical modeling with experimental approaches has provided important mechanistic insights, and call for a more expansive use of mathematical modeling...
Journal Articles
Journal: Development
Development (2017) 144 (6): 946–951.
Published: 15 March 2017
.... Organoids provide tractable conditions to investigate the effects of the growth environment, including its molecular composition and mechanical properties, along with the initial conditions such as cell number and type(s). From a theoretical standpoint, different types of in silico modeling can complement...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (18): 3350–3362.
Published: 15 September 2016
.... Here, we develop a detailed model of auxin transport in the Arabidopsis root tip and combine this with experiments to investigate the processes generating auxin asymmetry during halotropism. Our model points to the key role of root tip architecture in allowing the decrease in PIN2 at the salt-exposed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4288–4298.
Published: 15 December 2015
... and endocycles. Expression of a PIP degron mutant Dap attenuates endocycle progression but does not obviously affect proliferating diploid cells. A mathematical model of the endocycle predicts that the rate of destruction of Dap during S phase modulates the endocycle by regulating the length of G phase. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3902–3911.
Published: 15 November 2015
...Kathryn Atwell; Zhao Qin; David Gavaghan; Hillel Kugler; E. Jane Albert Hubbard; James M. Osborne The Caenorhabditis elegans germ line is an outstanding model system in which to study the control of cell division and differentiation. Although many of the molecules that regulate germ cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 625–639.
Published: 15 February 2012
... and mathematical models promise novel insight into the dynamic behavior of the clock. Box 4. Starting and finishing segmentation Although the material in the review focuses on the notion of steady-state segmentation, the segmentation of a vertebrate embryo has a beginning and end. Oscillation...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 889–900.
Published: 1 March 2006
... complex and are typically analyzed only at long times after secretion (i.e. steady state). We have developed a theoretical model that analyzes dynamically how the intricate transport and signal transduction mechanisms of a model morphogen, Sonic hedgehog (Shh),cooperate in modular fashion to regulate...
Includes: Multimedia, Supplementary data