... understanding of human development and how these new findings are being leveraged to improve in vitro model systems. Human development Cell atlas Model systems Over the past ∼25 years, a remarkable amount of progress has been made in the ability to culture human embryonic stem cells (hESCs...

... discuss the advantages and limitations of these model systems and suggest that a complementary approach, using combinations of in vivo and in vitro models, will broaden our knowledge of the molecular and cellular mechanisms that underlie defective neuronal positioning in the human cerebral cortex...

... National Foundation SNF 31003A_169930 Canton of Geneva 10.13039/100000002 Cell plasticity and cell reprogramming Blastema dynamics Model systems Immune response Transcriptional control of regeneration Wound healing Injury-induced signaling Senescence and ageing Summary...

... that have used a combination of powerful in vitro, in vivo and in silico model systems. Here, we summarise these models and discuss their advantages and disadvantages. We then review the different stages of blood vessel development, highlighting the cellular mechanisms and molecular players involved at each...

.... , Monteiro A. ( 2008 ). Are we there yet? Tracking the development of new model systems . Trends Genet. 24 , 353 - 360 . Amundson R. ( 2005 ). The Changing Role of the Embryo in Evolutionary Thought: Roots of Evo-Devo . Cambridge : Cambridge University Press . Appel T...