... receptors (FGFRs) are required for transcription of Dusp6 , which encodes MKP3, an extracellular signal-regulated kinase (ERK)-specific MKP. Targeted inactivation of Dusp6 increases levels of phosphorylated ERK, as well as the pERK target, Erm , and transcripts initiated from the Dusp6 promoter itself...

...-promoting Egfr function is transduced by the ERK-type MAPK pathway, but does not require the downstream transcription factor Pointed. Compromising Egfr signalling, by downregulating different elements of the pathway or by overexpressing the Mkp3 negative regulator, leads to loss of tube integrity,whereas...

... , and downregulation of MKP3 . These data demonstrate that FGF/FGFR1 signals play indispensable roles in the early stages of limb initiation, eliciting a profound effect on the later stages of limb development, including cell survival, autopod formation and digit patterning. * Author for correspondence (e...

... of mesenchymal progenitor cells in the dorsal sclerotome. We show that the levels of active,phosphorylated ERK protein in the developing somite are crucial for the expression of scleraxis and Mkp3 . MKP3 is a dual specificity phosphatase and a specific antagonist of ERK MAP kinases and we demonstrate...