.... Surprisingly only 10% of the endoderm transcriptome is regulated as predicted by the current linear model. We find that Nodal genes, Mixer and Sox17 have both shared and distinct sets of downstream targets, and that a number of unexpected autoregulatory loops exist between Sox17 and Gata4-6, between Sox17...

... and patterning of the endoderm and mesoderm. In addition, it is important to understand the mechanism that specifies the boundary between endoderm and mesoderm. One of the downstream targets of VegT, the homeodomain protein Mixer, is expressed at high levels at the mesoderm/endoderm boundary at the late blastula...

...Morgane Poulain; Thierry Lepage Endoderm specification in zebrafish is mediated by the zygotic transcription factors Bon/Mixer, Faust/Gata5, Casanova and Sox17, whose expression is induced by Nodal signalling. Bon/Mixer and Gata5 require Casanova in order to promote endoderm formation and all three...

..., Mixer, Xsox17 α, Gata4, Gata5, Gata6 and endodermin , as well as the anterior endodermal genes Xhex and cerberus , and the organizer specific gene, Xlim1 , are downstream of maternal VegT . We also find that the TGFβs, Xnr1, Xnr2, Xnr4 and derrière rescue expression of these genes, supporting the idea...