... that the original work is properly attributed. Left-Right Organizer Cell Patterning Rosette Lumen Formation Mitosis Cytokinesis Microtubules Cilia National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM-127621 R01GM-130874 Specific mitotic events...

... to demonstrate that EIF4A3 promotes cortical development by controlling progenitor mitosis, cell fate and survival. Eif4a3 haploinsufficiency in mice causes extensive cell death and impairs neurogenesis. Using Eif4a3 ; p53 compound mice, we show that apoptosis has the most impact on early neurogenesis, while...

... specific to chordate embryos, while modulation of SAC efficiency in SAC proficient stages depends on cell fate and cell size, which is similar to non-chordate embryos. Mitosis Ascidian Spindle assembly checkpoint Embryo SAC acquisition Kinetochore Conseil Régional Provence-Alpes-Côte...

... and peripheral myelination. Sil Schwann cell Peripheral nervous system Mitotic spindle MCPH Zebrafish Myelin PLLn Mitosis Laminin cAMP Institut National de la Santé et de la Recherche Médicale http://dx.doi.org/10.13039/501100001677 Université Paris-Saclay...

... ( Fig. 4 E). Interestingly, DNA extended beyond this tubulin ring and was negative for PH3 staining ( Fig. 4 Ea,b,c1). In the wild-type situation, Histone H3 phosphorylation begins in pericentromeric heterochromatin regions at the onset of mitosis. It then spreads along the entire length...

... breaks and chromosome pulverization from errors in mitosis . Nature 482 , 53 - 58 . 10.1038/nature10802 Daughtry , B. L. , Rosenkrantz , J. L. , Lazar , N. H. , Fei , S. S. , Redmayne , N. , Torkenczy , K. A. , Adey , A. , Yan , M. , Gao , L. , Park...

... in adult mouse incisor. Arid1a Mesenchymal stem cells Transit-amplifying cells Cell cycle Mitosis Stem cells reside in a variety of adult tissues, such as the mammalian hematopoietic and nervous systems, intestine and hair follicle ( Morrison et al., 1997 ). During tissue homeostasis...

... that is independent of its catalytic activity. EMT MMP14 Delamination Mitosis Neural crest Polarity Fondation pour la Recherche Médicale 10.13039/501100002915 FRM AJE201224 Conseil Régional Midi-Pyrénées 13053025 Toulouse Cancer Santé Centre national de la...

... in prolonged mitosis due to extension of early mitotic stages. This disruption is correlated with depletion of the populations of upper layer neurons in the cortex. In contrast, early cortical neural stem cells proliferate and expand normally in the absence of Sp2. These results indicate a stage-specific...

...-p26 silence nanos translation, downregulate a subset of microRNAs involved in germ cell differentiation and suppress ribosomal biogenesis via dMyc to limit germ cell mitosis. We also found that the human ortholog of Wh (WDR4) interacts with TRIM32 in human cells. Our results show that Wh...

... in interneuron loss. Our results demonstrate that interneuron development is intimately dependent upon progenitor mitosis duration and uncover a crucial post-transcriptional regulator of interneuron fate relevant for neurodevelopmental pathologies. This article has an associated ‘ The people behind the papers...

...Tadashi Nakagawa; Teng Zhang; Ryo Kushi; Seiji Nakano; Takahiro Endo; Makiko Nakagawa; Noriko Yanagihara; David Zarkower; Keiko Nakayama The mitosis-meiosis transition is essential for spermatogenesis. Specific and timely downregulation of the transcription factor DMRT1, and consequent induction...

... mitosis, Prkcb mediates phosphorylation-dependent lamin B1 disassembly, and inhibition or depletion of Prkcb delays nuclear envelope breakdown ( Mall et al., 2012 ). Possibly, reduced Prkcb expression might contribute to the delayed GVBD observed in Setdb1 −/− oocytes. We frequently saw transient...

... organs Mitosis G2 arrest Cell differentiation The development of a functional nervous system requires precise coordination of self-renewal, proliferation and differentiation to ensure that the correct numbers of properly specified neuronal and non-neuronal cell types are produced...

... Bax or Trp53 (also known as p53 ) rescues the survival of neural progenitors and reduces the growth restriction imposed by Aspm deletion. Our data show that Aspm functions to regulate mitosis and to mitigate DNA damage during CGNP cell division, causes microcephaly through progenitor apoptosis when...

...-to-microtubule adaptor protein, analogous to the role played by Dlg ( Fig. 4 ). Mud associates with cytoplasmic dynein, which serves as the sole minus-end-directed microtubule motor protein during mitosis. Dynein is a large protein complex consisting of core light, intermediate and heavy chains, the latter...

... role in the heritability of active gene expression programs through DNA synthesis and mitosis. Mitotic memory was also tackled by Ken Zaret (University of Pennsylvania, Philadelphia, USA), who showed examples of factors that remained bound to mitotic chromosomes (such as the Forkhead transcription...

...Leonardo G. Guilgur; Pedro Prudêncio; Tânia Ferreira; Ana Rita Pimenta-Marques; Rui Gonçalo Martinho Epithelial cells mostly orient the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells. The correct orientation of the spindle relies...

...Gonzalo Fernández-Miranda; Marianna Trakala; Javier Martín; Beatriz Escobar; Alejandra González; Norbert B. Ghyselinck; Sagrario Ortega; Marta Cañamero; Ignacio Pérez de Castro; Marcos Malumbres Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis...

... the donor nucleus and the recipient cell was not required at the time of transfer, as long as synchrony was reached by the first mitosis. Our findings demonstrate the remarkable flexibility of the reprogramming process and support the importance of nuclear transcriptional regulators in mediating...