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Keywords: Mitosis
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev198838.
Published: 16 April 2021
... Mesenchymal stem cells Transit-amplifying cells Cell cycle Mitosis Stem cells reside in a variety of adult tissues, such as the mammalian hematopoietic and nervous systems, intestine and hair follicle ( Morrison et al., 1997 ). During tissue homeostasis and regeneration, stem cells can self-renew...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev183954.
Published: 12 April 2020
...: MMP14 is required for the delamination of chick neural crest cells by promoting the basal positioning of nuclei during EMT, an effect that is independent of its catalytic activity. EMT MMP14 Delamination Mitosis Neural crest Polarity Par3 has been implicated in the regulation of cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev186056.
Published: 21 February 2020
... divisions results in prolonged mitosis due to extension of early mitotic stages. This disruption is correlated with depletion of the populations of upper layer neurons in the cortex. In contrast, early cortical neural stem cells proliferate and expand normally in the absence of Sp2. These results indicate a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
...-p26 silence nanos translation, downregulate a subset of microRNAs involved in germ cell differentiation and suppress ribosomal biogenesis via dMyc to limit germ cell mitosis. We also found that the human ortholog of Wh (WDR4) interacts with TRIM32 in human cells. Our results show that Wh is a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev182295.
Published: 13 January 2020
... interneuron loss. Our results demonstrate that interneuron development is intimately dependent upon progenitor mitosis duration and uncover a crucial post-transcriptional regulator of interneuron fate relevant for neurodevelopmental pathologies. This article has an associated ‘ The people behind the papers...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (22): 4137–4147.
Published: 15 November 2017
...Tadashi Nakagawa; Teng Zhang; Ryo Kushi; Seiji Nakano; Takahiro Endo; Makiko Nakagawa; Noriko Yanagihara; David Zarkower; Keiko Nakayama The mitosis-meiosis transition is essential for spermatogenesis. Specific and timely downregulation of the transcription factor DMRT1, and consequent induction of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2767–2779.
Published: 01 August 2016
... through meiosis and mitosis. Histone methylation Meiosis Mitosis Pre-implantation development Transcriptional regulation Mouse female germ cells enter meiosis during fetal development and arrest at the dictyate stage of meiotic prophase I shortly after birth until adulthood. During...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (7): 1160–1169.
Published: 01 April 2016
... development, G2-phase arrest serves a dual role: it prevents progenitor self-renewal and it synchronizes cell division with developmental signals. Neural development Sensory organs Mitosis G2 arrest Cell differentiation The development of a functional nervous system requires precise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3921–3932.
Published: 15 November 2015
... regulators Bax or Trp53 (also known as p53 ) rescues the survival of neural progenitors and reduces the growth restriction imposed by Aspm deletion. Our data show that Aspm functions to regulate mitosis and to mitigate DNA damage during CGNP cell division, causes microcephaly through progenitor apoptosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1843–1856.
Published: 01 May 2013
... the Pins-Mud spindle orientation complex. The energy-regulated AMP-activated kinase (AMPK; SNF1A in Drosophila ; PRKAA1 in mammals) localizes to spindle poles during mitosis, and a recent study of human cell culture systems demonstrated that loss of AMPK results in astral microtubule...
Journal Articles
Journal: Development
Development (2012) 139 (21): 3891–3896.
Published: 01 November 2012
...@csc.mrc.ac.uk ) Competing interests statement The authors declare no competing financial interests. © 2012. 2012 Chromatin Mitosis Epigenetics Gene expression For more than a century it has been known that ‘heritable traits’, or gene expression patterns, are faithfully transmitted...
Journal Articles
Journal: Development
Development (2012) 139 (3): 503–513.
Published: 01 February 2012
...Leonardo G. Guilgur; Pedro Prudêncio; Tânia Ferreira; Ana Rita Pimenta-Marques; Rui Gonçalo Martinho Epithelial cells mostly orient the spindle along the plane of the epithelium (planar orientation) for mitosis to produce two identical daughter cells. The correct orientation of the spindle relies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2661–2672.
Published: 01 July 2011
...Gonzalo Fernández-Miranda; Marianna Trakala; Javier Martín; Beatriz Escobar; Alejandra González; Norbert B. Ghyselinck; Sagrario Ortega; Marta Cañamero; Ignacio Pérez de Castro; Marcos Malumbres Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 1953–1963.
Published: 15 June 2010
... between the donor nucleus and the recipient cell was not required at the time of transfer, as long as synchrony was reached by the first mitosis. Our findings demonstrate the remarkable flexibility of the reprogramming process and support the importance of nuclear transcriptional regulators in mediating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 2011–2021.
Published: 15 June 2010
... mitosis are responsible for spindle positioning, leading to precise orientation of the cleavage furrow during ACD in the cells that give rise to the germ lineage in ascidians. * Author for correspondence ( alex.mc-dougall@obs-vlfr.fr ) Competing interests statement The authors declare no...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 953–961.
Published: 15 March 2010
... widespread failure of replicated chromosomes to disjoin. Surprisingly, rsw4 has neither pronounced cell cycle arrest nor anomalous spindle formation, which occur in other eukaryotes upon loss of separase activity. However, rsw4 roots have disorganized cortical microtubules and accumulate the mitosis-specific...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 449–459.
Published: 01 February 2009
... phenotype. CHK2-mediated mitotic arrest has been previously shown to occur in response to mitotic entry with DNA damage or incompletely replicated DNA. Syncytial embryos lacking NOPO exhibit a shorter interphase during cycle 11, suggesting that they may enter mitosis prior to the completion of DNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3049–3054.
Published: 01 September 2007
... © 2007. 2007 Tissue elongation Planar cell polarity Pair rule string Mitosis Drosophila The best-known example of tissue elongation is the extension of the vertebrate axis following gastrulation. In Xenopus , elongation of the prospective notochord is driven by convergence and...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (16): 3201–3211.
Published: 15 August 2006
...Achim Reber; Christian F. Lehner; Henning W. Jacobs Cyclin A expression is only required for particular cell divisions during Drosophila embryogenesis. In the epidermis, Cyclin A is strictly required for progression through mitosis 16 in cells that become post-mitotic after this division. By...
Journal Articles
Journal: Development
Development (2005) 132 (20): 4509–4520.
Published: 15 October 2005
... functional because in mutant embryos, polar body chromatin undergoes cycles of condensation-decondensation with additional rounds of DNA replication. Our results suggest that BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the...
Includes: Multimedia, Supplementary data