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Keywords: Mitochondria
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev197343.
Published: 26 April 2021
... metamorphosis ( Cohen et al., 2020 ; Wessing and Eichelberg, 1978 ). Indeed, we found that larval (early L3) and adult tubules exhibited rapid tubule secretion rates (Ramsay assays, Fig. 2 C) and this was associated with renal tubule cells possessing a highly active, hyperpolarized mitochondria (high membrane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
... multiple metabolic events and processes in the mitochondria from E10.5 and safeguards the continuously increased metabolic activity to meet the demands from heart development and contraction. The temporal window of E10.5-E14.5 was a crucial turning point for mitochondrial morphogenesis and maturation, and...
Includes: Supplementary data
Journal Articles
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Reproductive biology
Journal: Development
Development (2021) 148 (8): dev197558.
Published: 16 April 2021
... morphological defects, including a novel conjoined phenotype, and impaired fertility. PRSS50 LRWD1 NFκB IκB AKAP4 SEPT12 H3K9me3 Infertility MMAF Mitochondria Centrosome Midpiece Sperm tail Funding The authors’ research is supported by the National Institute of Health (NIH). C.J.J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175786.
Published: 11 June 2020
.... ( 2020 ). Alternative splicing in aging and longevity . Hum. Genet.   139 , 357 - 369 . 10.1007/s00439-019-02094-6 Bian , Z. , Li , L.-M. , Tang , R. , Hou , D.-X. , Chen , X. , Zhang , C.-Y. and Zen , K. ( 2010 ). Identification of mouse liver mitochondria...
Journal Articles
Journal: Development
Development (2020) 147 (10): dev188714.
Published: 26 May 2020
...Agnes Cheong; Danielle Archambault; Rinat Degani; Elizabeth Iverson; Kimberly D. Tremblay; Jesse Mager ABSTRACT Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper function of...
Journal Articles
Journal: Development
Development (2019) 146 (20): dev182857.
Published: 24 October 2019
... same stage of forebrain specification. Progenitors showed striking mitochondrial structural changes transitioning from glycolytic cristae at E8.5, to more traditional mitochondria at E10.5. Accordingly, glucose use shifted in progenitors such that E8.5 progenitors relied on glycolysis, and after NTC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev168609.
Published: 26 September 2018
...-1/ Highlighted Article:   Pitx2 is important in the maintenance of the proper cellular composition of the regenerating myocardium by reducing mitochondrial dysfunction and preventing fat accumulation. Mouse Myocardial infarction Cardiac regeneration Mitochondria Adipogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev143420.
Published: 13 April 2018
...Hongbo Zhang; Keir J. Menzies; Johan Auwerx ABSTRACT The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3193–3198.
Published: 15 September 2017
.... Published by The Company of Biologists Ltd 2017 Summary: This Meeting Review of the 2017 EMBO/EMBL Symposium ‘Metabolism in Time and Space’ summarizes recent findings that emphasize how metabolism and developmental biology are inseparably linked in animals and plants. Metabolism Mitochondria...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (13): 2490–2503.
Published: 01 July 2017
... production, which was further enhanced by the incompatibility with simw 501 mitochondria. Mito-nuclear incompatibility also resulted in aberrant egg morphology and a maternal-effect on embryonic chromosome segregation and survival, which was completely dependent on the temperature and mito-nuclear genotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2175–2186.
Published: 15 June 2017
..., where it colocalizes at myofilaments with ARX-2, a component of the Arp2/3 actin-nucleation complex. Genetic studies suggest that SMN-1 promotes Arp2/3 activity important for localizing mitochondria to I-bands. Our results support the model that VAPB homologs are circulating hormones that pattern the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4203–4213.
Published: 15 November 2016
... require the regulation of kinesin and dynein by two adaptor proteins, Milton and Miro. Recently, we found that dynein heavy chain 64C ( Dhc64C ) is the primary motor protein for both anterograde and retrograde transport of mitochondria in the Drosophila bristle. In this study, we show that a molecular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 681–691.
Published: 15 February 2015
..., indicating that maternal obesity before conception had altered the transmission of mitochondria to offspring. Treatment of the obese females with the ER stress inhibitor salubrinal or the chaperone inducer BGP-15 before ovulation increased the amount of the mitochondrial replication factors TFAM and DRP1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4206–4218.
Published: 15 November 2014
... cells Metabolism Mitochondria Reactive oxygen species (ROS) have been increasingly implicated in the physiological regulation of crucial developmental processes, e.g. the emergence of embryonic blood stem cells or differentiation of embryonic cardiomyocytes ( Harris et al., 2013 ; Hernández...
Journal Articles
Journal: Development
Development (2012) 139 (21): 4083–4093.
Published: 01 November 2012
... correspondence ( kazuk@kochi-u.ac.jp ) Competing interests statement The authors declare no competing financial interests. 3 8 2012 © 2012. 2012 Budding Eed Mitochondria Polycomb group Senescence Tunicate P. misakiensis All eukaryotes inevitably undergo senescence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2966–2977.
Published: 15 August 2012
... BCDO2 in human cell lines. We found that carotenoids caused oxidative stress in mitochondria that eventually led to cytochrome c release, proteolytic activation of caspase 3 and PARP1, and execution of the apoptotic pathway. Moreover, BCDO2 prevented this induction of the apoptotic pathway by...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 327–338.
Published: 15 January 2011
... dynamics during germline cell death in the Drosophila melanogaster ovary. We find that mitochondria undergo a series of events during the progression of cell death, with remodeling, cluster formation and uptake of clusters by somatic follicle cells. These mitochondrial dynamics are dependent on caspases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2587–2596.
Published: 01 August 2010
... avoid mitochondria-damaging agents. In summary, this paper introduces a faithful Costeff Syndrome model and demonstrates a requirement for mitochondrial OPA3 to limit HMG-CoA-derived MGC and protect the electron transport chain against inhibitory compounds. * Author for correspondence ( bfeldman...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (22): 3757–3766.
Published: 15 November 2009
...Asako Tsubouchi; Taiichi Tsuyama; Makio Fujioka; Haruyasu Kohda; Keiko Okamoto-Furuta; Toshiro Aigaki; Tadashi Uemura Dynamic morphological changes in mitochondria depend on the balance of fusion and fission in various eukaryotes, and are crucial for mitochondrial activity. Mitochondrial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (15): 2669–2679.
Published: 01 August 2008
... synapse. Thus, alterations in electron transport chain function explain many of the neurodegenerative changes seen in both early- and late-onset disorders. * Author for correspondence (e-mail: trc@stanford.edu ) 23 5 2008 © 2008. 2008 Drosophila ROS Degeneration Mitochondria...
Includes: Supplementary data