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Keywords: Mitf
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Journal Articles
Journal: Development
Development dev.194407.
Published: 08 December 2021
... lineage. Indeed, β-catenin regulates Mitf-M transcription, the master regulator of this lineage. The first wave of melanocytes to colonize the skin is directly derived from neural crest cells, while the second wave of melanocytes is derived from Schwann-cell precursors (SCPs). We investigated...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187047.
Published: 13 July 2020
... through which vasculature enters the eye and ganglion cell axons exit. Although many factors have been identified that function during CF closure, the molecular and cellular mechanisms mediating this process remain poorly understood. Failure of CF closure results in colobomas. Recently, MITF was shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 620–632.
Published: 15 February 2015
... and differentiation, melanocyte stem cells, and the role of the melanocyte lineage in diseases such as melanoma. MITF Melanoma Neural crest Stem cells Melanin, the pigment that colours the skin, eyes, hair, fur, feathers and scales of vertebrates (see Box 1 ), is made by specialised cells called...
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... or inhibition of Wnt, but not Wnt/β-catenin, signalling prevents pigmentation and downregulates the RPE regulatory gene Mitf . Activation of BMP or Wnt signalling can replace the surface ectoderm to rescue MITF expression and optic cup formation. We provide evidence that BMPs and Wnts cooperate via a GSK3β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 01 July 2013
..., ocular coloboma. Defective FGF signaling does not abrogate Shh or BMP signaling, nor does it affect axial patterning of the optic vesicle. Instead, FGF signaling regulates Mitf and Pax2 in coordinating the closure of the optic fissure and optic disc specification, which is necessary for the outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2269–2279.
Published: 01 June 2013
... the melanogenic markers Mitf and MC/1 and the guidance receptor Ednrb2, generating instead glial cells that express P0 and Fabp. In this context, Foxd3 lies downstream of Snail2 and Sox9 , constituting a minimal network upstream of Mitf and Ednrb2 to link melanogenic specification with migration. Consistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3943–3954.
Published: 15 September 2011
... alone or gfp and Mitf have been described elsewhere ( Gaggioli et al., 2003 ). Melanocyte proliferation was analyzed by BrdU labeling in vivo, with embryos at various stages of development. The mother was given two 50 μg/ml BrdU injections at 20-minute intervals and killed 2 hours later. Embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1849–1858.
Published: 01 June 2009
... is expressed exclusively in the neural/glial precursors and MITF is expressed only in melanoblasts. Moreover, FOXD3 represses melanogenesis. Here we show that avian MITF expression begins very early during melanoblast migration and that loss of MITF in melanoblasts causes them to transdifferentiate to a glial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (1): 177–187.
Published: 01 January 2005
... (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitf is a determinant of RPE identity. We report here that Mitf...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (20): 5139–5152.
Published: 15 October 2004
.... This program involved the expansion of expression of genes normally found only in the periphery into central regions of the eye. These genes included a transcription factor controlling pigmentation, Mitf , and the related factor Tfec ( Tcfec – Mouse Genome Informatics), which can activate a melanogenic gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3239–3247.
Published: 15 July 2004
... of EDN3 (not shown). The addition of Kitl Sl /Kitl Sl NTs to Ednrb lacZ / Ednrb lacZ cultures indeed showed that in contrast to Kitl -positive Mitf mi–ew /Mitf mi–ew NTs, Kitl -deficient NTs do not allow for Ednrb -deficient cells to become tyrosinase positive ( Fig. 3C...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6545–6553.
Published: 29 December 2003
... specific isoform of the microphtalmia-related transcription factor (Mitf). Mitf is a basic helix-loop-helix-leucine zipper transcription factor whose M isoform is restricted to neural crest derived melanocytes and is essential for the development of these cells in vertebrates from mammals to fish. What...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2903–2915.
Published: 01 July 2003
...-epithelial and optic-stalk progenitor domains, suggesting redundant functions during retinal determination. Pax2; Pax6 compound mutants display a dose-dependent reduction in the expression of the melanocyte determinant Mitf, accompanied by transdifferentiation of retinal pigmented epithelium (RPE...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2809–2818.
Published: 15 June 2003
... of the transcription factor mitfa , which itself is required for melanophore development. We demonstrate that the zebrafish mitfa promoter has sox10 binding sites necessary for activity in vitro, consistent with studies using mammalian cell cultures that have shown that Sox10 directly regulates Mitf expression...