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Keywords: Mitf
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Journal Articles
Journal: Development
Development (2022) 149 (2): dev194407.
Published: 24 January 2022
... the melanocyte lineage. Indeed, β-catenin regulates transcription of Mitf-M, the master regulator of this lineage. The first wave of melanocytes to colonize the skin is directly derived from neural crest cells, whereas the second wave of melanocytes is derived from Schwann cell precursors (SCPs). We investigated...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (4): 620–632.
Published: 15 February 2015
... and differentiation, melanocyte stem cells, and the role of the melanocyte lineage in diseases such as melanoma. MITF Melanoma Neural crest Stem cells Melanin, the pigment that colours the skin, eyes, hair, fur, feathers and scales of vertebrates (see Box 1 ), is made by specialised cells called...
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... or inhibition of Wnt, but not Wnt/β-catenin, signalling prevents pigmentation and downregulates the RPE regulatory gene Mitf . Activation of BMP or Wnt signalling can replace the surface ectoderm to rescue MITF expression and optic cup formation. We provide evidence that BMPs and Wnts cooperate via a GSK3β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 1 July 2013
..., ocular coloboma. Defective FGF signaling does not abrogate Shh or BMP signaling, nor does it affect axial patterning of the optic vesicle. Instead, FGF signaling regulates Mitf and Pax2 in coordinating the closure of the optic fissure and optic disc specification, which is necessary for the outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2269–2279.
Published: 1 June 2013
... the melanogenic markers Mitf and MC/1 and the guidance receptor Ednrb2, generating instead glial cells that express P0 and Fabp. In this context, Foxd3 lies downstream of Snail2 and Sox9 , constituting a minimal network upstream of Mitf and Ednrb2 to link melanogenic specification with migration. Consistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 3943–3954.
Published: 15 September 2011
... ( lionel.larue@curie.fr ; veronique.delmas@curie.fr ) * These authors contributed equally to this work. Competing interests statement The authors declare no competing financial interests. 16 6 2011 © 2011. Mitf Dct β-Catenin Melanoblast Mouse Mice...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (1): 177–187.
Published: 1 January 2005
... (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitf is a determinant of RPE identity. We report here that Mitf...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (20): 5139–5152.
Published: 15 October 2004
.... This program involved the expansion of expression of genes normally found only in the periphery into central regions of the eye. These genes included a transcription factor controlling pigmentation, Mitf , and the related factor Tfec ( Tcfec – Mouse Genome Informatics), which can activate a melanogenic gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3239–3247.
Published: 15 July 2004
... ) and then intercrossed the double heterozygotes. Mice carrying the Kitl Sl allele on a WC/ReJ background were obtained from Jackson Laboratories and bred with C57BL/6xC3H/HeJ F1 mice. Mice carrying the allele Mitf mi–ew on a Naw background were originally obtained form N. Jenkins/N. Copeland. Noon on the day...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6545–6553.
Published: 29 December 2003
... specific isoform of the microphtalmia-related transcription factor (Mitf). Mitf is a basic helix-loop-helix-leucine zipper transcription factor whose M isoform is restricted to neural crest derived melanocytes and is essential for the development of these cells in vertebrates from mammals to fish. What...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2903–2915.
Published: 1 July 2003
...-epithelial and optic-stalk progenitor domains, suggesting redundant functions during retinal determination. Pax2; Pax6 compound mutants display a dose-dependent reduction in the expression of the melanocyte determinant Mitf, accompanied by transdifferentiation of retinal pigmented epithelium (RPE...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2809–2818.
Published: 15 June 2003
... of the transcription factor mitfa , which itself is required for melanophore development. We demonstrate that the zebrafish mitfa promoter has sox10 binding sites necessary for activity in vitro, consistent with studies using mammalian cell cultures that have shown that Sox10 directly regulates Mitf expression...
Journal Articles
Journal: Development
Development (2000) 127 (21): 4599–4609.
Published: 1 November 2000
... is required for the induction and maintenance of expression of the RPE-specific genes Mitf and Wnt13 and the melanosomal matrix protein MMP115. In the absence of extraocular tissues, RPE development did not occur. Replacement of the extraocular mesenchyme with cranial mesenchyme, but not lateral plate...
Journal Articles
Journal: Development
Development (2000) 127 (17): 3715–3724.
Published: 1 September 2000
... or no role in wild-type fin stripe development, thus revealing a secondary mode for regulation of fin stripes. Expression of melanocyte markers in regenerating kit mutant fins suggests that kit normally acts after mitf and before dct to promote development of the primary kit -dependent melanocytes. kit...
Journal Articles
Journal: Development
Development (1999) 126 (17): 3757–3767.
Published: 1 September 1999
... in melanophores. We show that nac w2 is a mutation in a zebrafish gene encoding a basic helix-loop-helix/leucine zipper transcription factor related to microphthalmia ( Mitf ), a gene known to be required for development of eye and crest pigment cells in the mouse. Transient expression of the wild-type nacre gene...
Journal Articles
Journal: Development
Development (1998) 125 (21): 4205–4213.
Published: 1 November 1998
... for correspondence (e-mail: weston@uoneuro.uoregon.edu ) 14 8 1998 30 9 1998 © 1998 by Company of Biologists 1998 Neural crest Migration Hu mitf Melanocyte Apoptosis Chick Quail Presently, it is not clear what mechanism(s) are involved in the death of neurogenic/neuronal...