... continuous proliferation and differentiation within the intestinal crypts, migrating towards the luminal surface where they are eventually shed. RAB GTPases are key regulators of intracellular vesicular trafficking and are involved in various cellular processes, including cell migration and polarity. Here...

...), are one of the first cell types specified during embryogenesis. In fact, PGCs form well before the bipotential somatic gonad is specified. This common feature of germline development necessitates that PGCs migrate through many tissues to reach the somatic gonad. During their journey, PGCs must respond...

... transition-like manner, rearranging apical polarity and primary cilia proteins. We also show that, once delaminated, NBs require RhoGTPases in order to perform active migration. Furthermore, tracking of recently delaminated NBs revealed their directed migration and coalescence around a small population...

... Progenitor scRNA-seq analysis PSC Migration Hemocytes Plasmatocytes Lamellocytes Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 BO1890/5-1 Volkswagen Foundation http://dx.doi.org/10.13039/501100001663 Philipps-Universität Marburg http...

...Lukasz Truszkowski; Dilek Batur; Hongyan Long; Katsiaryna Tarbashevich; Bart E. Vos; Britta Trappmann; Erez Raz ABSTRACT In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their environment. As an in vivo model for this process, we use...

...Wei Zhang; Jiaojiao Yu; Guoquan Fu; Jianying Li; Huarong Huang; Jing Liu; Dongliang Yu; Mengsheng Qiu; Feixue Li ABSTRACT Migration of myoblasts derived from the occipital somites is essential for tongue morphogenesis. However, the molecular mechanisms of myoblast migration remain elusive...

...André Rosa; Wolfgang Giese; Katja Meier; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; Anna Szymborska; Baptiste Coxam; Miguel O. Bernabeu; Holger Gerhardt ABSTRACT Endothelial cell migration and proliferation are essential for the establishment...

... thickening of the epithelium in the diastema anterior to the first developing molar is an early signaling center, the molar initiation knot (IK), which is required for the progression of mammalian molar tooth development. Cell division Migration Embryonic development Tooth Signaling center Wnt...

... delaminate from the myotome, migrate to the developing limb bud, and proliferate ( Buckingham et al., 2003 ). Once these cells are in the limb bud, expression of MyoD , a determination factor for the myogenic lineage, results in their differentiation into skeletal muscle ( Rudnicki et al., 1993...

... in physiology and development is surprisingly little understood. Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse the dermis to reach the epidermis, colonising the skin and eventually homing within the hair follicles. We have previously established that Rac1 and Cdc42...

...Susannah H. Kassmer; Delany Rodriguez; Anthony W. De Tomaso ABSTRACT The colonial ascidian Botryllus schlosseri regenerates the germline during repeated cycles of asexual reproduction. Germline stem cells (GSCs) circulate in the blood and migrate to new germline niches as they develop...

...Pietro Fazzari; Niall Mortimer; Odessa Yabut; Daniel Vogt; Ramon Pla ABSTRACT Cortical interneurons (CINs) originate in the ganglionic eminences (GEs) and migrate tangentially to the cortex guided by different attractive and repulsive cues. Once inside the cortex, the cellular and molecular...

...Amanda Haage; Kelsey Wagner; Wenjun Deng; Bhavya Venkatesh; Caitlin Mitchell; Katharine Goodwin; Aaron Bogutz; Louis Lefebvre; Catherine D. Van Raamsdonk; Guy Tanentzapf ABSTRACT Melanoblasts disperse throughout the skin and populate hair follicles through long-range cell migration. During...

... tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing or financial interests...

...Dianna J. Prince; Jason R. Jessen ABSTRACT Lateral zebrafish hypoblast cells initiate dorsal convergence near mid-gastrulation and exhibit non-polarized morphologies, limited cell-cell contact and indirect migration trajectories. By late gastrulation, mesodermal cells become packed as they engage...

... an anterior-posterior axis. We also developed a novel cell tracking technique that detected robust fate-dependent cell migrations in our gastruloids comparable with those found in the mouse embryo. Taken together, our fate map and recording of cell migrations provides a first coarse view of what the human PS...

... 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ The precision with which neurons are connected during development underpins the function of the nervous system. Several processes, such as neurogenesis, migration, dendritic...

... levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration...

... transition of neural crest cells to emigrate from the neural tube, miR-203 displays a reciprocal expression pattern with key regulators of neural crest delamination, Phf12 and Snail2 , and interacts with their 3′UTRs. We show that ectopic maintenance of miR-203 inhibits neural crest migration in chick...

...Anna M. Love; Dianna J. Prince; Jason R. Jessen ABSTRACT During zebrafish gastrulation the planar cell polarity (PCP) protein Vang-like 2 (Vangl2) regulates the polarization of cells that are engaged in directed migration. However, it is unclear whether Vangl2 influences membrane-protrusive...