...Sebastian Dworkin; Charbel Darido; Smitha R. Georgy; Tomasz Wilanowski; Seema Srivastava; Felix Ellett; Luke Pase; Yanchao Han; Anming Meng; Joan K. Heath; Graham J. Lieschke; Stephen M. Jane The isthmic organiser located at the midbrain-hindbrain boundary (MHB) is the crucial developmental...

... ) * Present address: MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0HS, UK Competing interests statement The authors declare no competing financial interests. 17 6 2011 © 2011. Midbrain-hindbrain boundary Organiser Notch signalling...

...Jovica Ninkovic; Christian Stigloher; Christina Lillesaar; Laure Bally-Cuif Neuronal production in the midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube depends on a progenitor pool called the `intervening zone' (IZ), located at the midbrain-hindbrain boundary. The progressive...

... coherence of the midbrain arc pattern. Finally, HH signaling is required for the integrity and the signaling properties of the boundaries of the midbrain (e.g. the midbrain-hindbrain boundary, the dorsoventral boundary), its perturbations resulting in abnormal cell mixing across `leaky' borders. © 2007...

... © 2006. 2006 Neural stem cell Zebrafish her5 E(Spl) Midbrain-hindbrain boundary Neurogenesis in the adult vertebrate brain is a fascinating but very restricted phenomenon that, despite intense investigation, remains incompletely understood. The capacity to renew neuronal...

... restriction. In order to address segmentation in the midbrain-hindbrain boundary (mhb) region, we have analyzed single cell behavior in the living embryo by acquiring time-lapse movies of the developing mhb region in a transgenic zebrafish line. We traced the movement of hundreds of nuclei, and by matching...

...Muriel Rhinn; Klaus Lun; Marta Luz; Michaela Werner; Michael Brand The organizing center located at the midbrain-hindbrain boundary (MHB)patterns the midbrain and hindbrain primordia of the neural plate. Studies in several vertebrates showed that the interface between cells expressing Otx and Gbx...

... neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate. This involves selective suppression of both neurogenin1 ( ngn1 ) and coe2 mRNA expression in a process that is independent of Notch signalling, and where inhibition of either ngn1 or coe2 expression is sufficient...

...Alexandra Tallafuß; Laure Bally-Cuif The midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube develops in response to the isthmic organizer (IsO), located at the midbrain-hindbrain boundary (MHB). MH derivatives are largely missing in mutants affected in IsO activity; however...

... a neuron-free zone (`intervening zone', IZ) at the midbrain-hindbrain boundary(MHB). The mechanisms establishing this early pattern of neurogenesis are unknown. We demonstrate that the MHB is globally refractory to neurogenesis,and that forced neurogenesis in this area interferes with the continued...

... of the midbrain-hindbrain boundary (MHB) domain, the neural crest and trigeminal neurons, raising the possibility that iro1 and iro7 have a role in determination of these ectodermal derivatives. A knockdown of iro7 function revealed that iro7 is essential for the determination of neurons in the trigeminal placode...

...-mail: [email protected] ) 22 10 2001 © 2002. 2002 Pax2 Midbrain-hindbrain boundary Enhancer Mouse Pufferfish BAC transgenes The anterior neural plate of the vertebrate embryo is patterned into the forebrain, midbrain and hindbrain under the influence of local...

...Alexander Picker; Caroline Brennan; Frank Reifers; Jonathan D. W. Clarke; Nigel Holder; Michael Brand ABSTRACT The organizer at the midbrain-hindbrain boundary (MHB organizer) has been proposed to induce and polarize the midbrain during development. We investigate the requirement for the MHB...

...Zbynek Kozmik; Nicholas D. Holland; Anna Kalousova; Jan Paces; Michael Schubert; Linda Z. Holland ABSTRACT On the basis of developmental gene expression, the vertebrate central nervous system comprises: a forebrain plus anterior midbrain, a midbrain-hindbrain boundary region (MHB) having organizer...