...Haewon Byun; Hae-Lim Lee; Hong Liu; Douglas Forrest; Andrii Rudenko; In-Jung Kim ABSTRACT Developmental control of long-range neuronal connections in the mammalian midbrain remains unclear. We explored the mechanisms regulating target selection of the developing superior colliculus (SC). The SC...

...Laura Lahti; Maarja Haugas; Laura Tikker; Mikko Airavaara; Merja H. Voutilainen; Jenni Anttila; Suman Kumar; Caisa Inkinen; Marjo Salminen; Juha Partanen Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic and hindbrain serotonergic pathways...

...Ernest Arenas; Mark Denham; J. Carlos Villaescusa ABSTRACT Midbrain dopaminergic (mDA) neuron development has been an intense area of research during recent years. This is due in part to a growing interest in regenerative medicine and the hope that treatment for diseases affecting mDA neurons...

... networks in different neuronal systems: neuronal migration, cell positioning and axon wiring. However, it is not known whether it regulates the development of A9-A10 tyrosine hydroxylase positive (TH + ) midbrain dopaminergic (mDA) neurons. We report here that Cxcl12 is expressed in the meninges...

... . Alvarez-Fischer D. , Fuchs J. , Castagner F. , Stettler O. , Massiani-Beaudoin O. , Moya K. L. , Bouillot C. , Oertel W. H. , Lombès A. , Faigle W. , et al . ( 2011 ). Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I...

... Epigenetics Gene regulation Midbrain If you turn this page, both the decision you make and the action that you carry out are significantly influenced by the amount of dopamine (DA; see Glossary, Box 1 ) released from dopaminergic neurons within your brain. Mesodiencephalic dopaminergic (mdDA...

...Jasmine Yang; Ashly Brown; Debra Ellisor; Erin Paul; Nellwyn Hagan; Mark Zervas Wnt1 -expressing progenitors generate midbrain dopamine (MbDA) and cerebellum (Cb) neurons in distinct temporal windows and from spatially discrete progenitor domains. It has been shown that Wnt1 and Lmx1a participate...

... Competing interests statement The authors declare no competing financial interests. 11 6 2012 © 2012. Midbrain Neuronal migration Parkinson’s disease Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually...

... poorly understood. The induction of midbrain DA neurons requires sonic hedgehog (Shh) from the floor plate and fibroblast growth factor 8 (FGF8) from the isthmic organizer, but the way in which FGF8 regulates DA neuron development is unclear. We show that, during early embryogenesis, mesodiencephalic...

...Qiaolin Deng; Elisabet Andersson; Eva Hedlund; Zhanna Alekseenko; Eva Coppola; Lia Panman; James H. Millonig; Jean-Francois Brunet; Johan Ericson; Thomas Perlmann The severe disorders associated with a loss or dysfunction of midbrain dopamine neurons (DNs) have intensified research aimed...

... Tight junctions Adherens junctions Interkinetic nuclear migration Midbrain Chick During neurulation, a flat neural plate rolls up to form a closed neural tube. This process involves diverse cell behaviors at specialized regions of the neural plate called hinge points (HPs...

... are restricted to the forebrain, whereas all other regions are essentially quiescent. However, ablation of midbrain dopamine neurons in newts induced ependymoglia cells in the normally quiescent midbrain to proliferate and to undertake full dopamine neuron regeneration. Using oligonucleotide microarrays, we have...

... midbrain oculomotor complex (OMC) as a model with which to study the developmental mechanisms of nucleogenesis. The chick OMC comprises two distinct cell groups: a dorsal Edinger-Westphal nucleus of visceral oculomotor neurons and a ventral nucleus of somatic oculomotor neurons. Genetic studies in mice...

...Zsuzsa Agoston; Dorothea Schulte The transcription factor Otx2 is expressed throughout the anterior neuroectoderm and is required for the formation of all forebrain- and midbrain-derived structures. The molecular determinants that cooperate with Otx2 to subdivide its expression domain into distinct...

... ). RNA was isolated from dissected ventral midbrains of E14.5 Nurr1 -/- and Nurr1 +/+ embryos or from MN9D cells using Trizol according to the supplied protocol (Invitrogen). Microarray analysis was performed in triplicate and for each experimental sample a dye swap was performed to correct for dye...

...Kaia Kala; Maarja Haugas; Kersti Lilleväli; Jordi Guimera; Wolfgang Wurst; Marjo Salminen; Juha Partanen Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active...

...M. Albert Basson; Diego Echevarria; Christina Petersen Ahn; Anamaria Sudarov; Alexandra L. Joyner; Ivor J. Mason; Salvador Martinez; Gail R. Martin Prospective midbrain and cerebellum formation are coordinated by FGF ligands produced by the isthmic organizer. Previous studies have suggested...

...Anna L. M. Ferri; Wei Lin; Yannis E. Mavromatakis; Julie C. Wang; Hiroshi Sasaki; Jeffrey A. Whitsett; Siew-Lan Ang The role of transcription factors in regulating the development of midbrain dopaminergic (mDA) neurons is intensively studied owing to the involvement of these neurons in diverse...

.... 2007 Pitx3 Retinoic acid Aldehyde dehydrogenase Development Midbrain Dopamine Parkinson's disease Ahd2 aldh1a1 Mouse Parkinson's disease (PD) is a common progressive neurodegenerative movement disorder attributed to selective loss of pigmented dopaminergic (DA) neurons...

... is the key regulator of GABAergic neurons, controlling their specification in the dorsal midbrain. Another conclusion from our results is that the function of Mgn shows a previously unrecognized role for h/E(spl) -related transcription factors in the dorsal midbrain GABAergic cell differentiation. Vertebrate...