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Keywords: Midbrain
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Neural development
Journal: Development
Development (2019) 146 (14): dev171926.
Published: 22 July 2019
...Haewon Byun; Hae-Lim Lee; Hong Liu; Douglas Forrest; Andrii Rudenko; In-Jung Kim ABSTRACT Developmental control of long-range neuronal connections in the mammalian midbrain remains unclear. We explored the mechanisms regulating target selection of the developing superior colliculus (SC). The SC...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2015) 142 (11): 1918–1936.
Published: 1 June 2015
...Ernest Arenas; Mark Denham; J. Carlos Villaescusa ABSTRACT Midbrain dopaminergic (mDA) neuron development has been an intense area of research during recent years. This is due in part to a growing interest in regenerative medicine and the hope that treatment for diseases affecting mDA neurons...
Journal Articles
Journal: Development
Development (2013) 140 (22): 4554–4564.
Published: 15 November 2013
... networks in different neuronal systems: neuronal migration, cell positioning and axon wiring. However, it is not known whether it regulates the development of A9-A10 tyrosine hydroxylase positive (TH + ) midbrain dopaminergic (mDA) neurons. We report here that Cxcl12 is expressed in the meninges...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3373–3384.
Published: 15 August 2013
... . Alvarez-Fischer D. , Fuchs J. , Castagner F. , Stettler O. , Massiani-Beaudoin O. , Moya K. L. , Bouillot C. , Oertel W. H. , Lombès A. , Faigle W. , et al . ( 2011 ). Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1159–1169.
Published: 15 March 2013
... Epigenetics Gene regulation Midbrain If you turn this page, both the decision you make and the action that you carry out are significantly influenced by the amount of dopamine (DA; see Glossary, Box 1 ) released from dopaminergic neurons within your brain. Mesodiencephalic dopaminergic (mdDA...
Journal Articles
Journal: Development
Development (2013) 140 (6): 1342–1352.
Published: 15 March 2013
...Jasmine Yang; Ashly Brown; Debra Ellisor; Erin Paul; Nellwyn Hagan; Mark Zervas Wnt1 -expressing progenitors generate midbrain dopamine (MbDA) and cerebellum (Cb) neurons in distinct temporal windows and from spatially discrete progenitor domains. It has been shown that Wnt1 and Lmx1a participate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3136–3141.
Published: 1 September 2012
... Competing interests statement The authors declare no competing financial interests. 11 6 2012 © 2012. Midbrain Neuronal migration Parkinson’s disease Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 894–905.
Published: 1 March 2012
... poorly understood. The induction of midbrain DA neurons requires sonic hedgehog (Shh) from the floor plate and fibroblast growth factor 8 (FGF8) from the isthmic organizer, but the way in which FGF8 regulates DA neuron development is unclear. We show that, during early embryogenesis, mesodiencephalic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3399–3408.
Published: 15 August 2011
...Qiaolin Deng; Elisabet Andersson; Eva Hedlund; Zhanna Alekseenko; Eva Coppola; Lia Panman; James H. Millonig; Jean-Francois Brunet; Johan Ericson; Thomas Perlmann The severe disorders associated with a loss or dysfunction of midbrain dopamine neurons (DNs) have intensified research aimed...
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Journal Articles
Journal: Development
Development (2011) 138 (15): 3179–3188.
Published: 1 August 2011
... Tight junctions Adherens junctions Interkinetic nuclear migration Midbrain Chick During neurulation, a flat neural plate rolls up to form a closed neural tube. This process involves diverse cell behaviors at specialized regions of the neural plate called hinge points (HPs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4127–4134.
Published: 15 December 2010
... are restricted to the forebrain, whereas all other regions are essentially quiescent. However, ablation of midbrain dopamine neurons in newts induced ependymoglia cells in the normally quiescent midbrain to proliferate and to undertake full dopamine neuron regeneration. Using oligonucleotide microarrays, we have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1205–1213.
Published: 1 April 2010
... midbrain oculomotor complex (OMC) as a model with which to study the developmental mechanisms of nucleogenesis. The chick OMC comprises two distinct cell groups: a dorsal Edinger-Westphal nucleus of visceral oculomotor neurons and a ventral nucleus of somatic oculomotor neurons. Genetic studies in mice...
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Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (14): 2363–2373.
Published: 15 July 2009
... ). RNA was isolated from dissected ventral midbrains of E14.5 Nurr1 -/- and Nurr1 +/+ embryos or from MN9D cells using Trizol according to the supplied protocol (Invitrogen). Microarray analysis was performed in triplicate and for each experimental sample a dye swap was performed to correct for dye...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (2): 253–262.
Published: 15 January 2009
...Kaia Kala; Maarja Haugas; Kersti Lilleväli; Jordi Guimera; Wolfgang Wurst; Marjo Salminen; Juha Partanen Midbrain GABAergic neurons control several aspects of behavior, but regulation of their development and diversity is poorly understood. Here, we further refine the midbrain regions active...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (14): 2673–2684.
Published: 15 July 2007
.... 2007 Pitx3 Retinoic acid Aldehyde dehydrogenase Development Midbrain Dopamine Parkinson's disease Ahd2 aldh1a1 Mouse Parkinson's disease (PD) is a common progressive neurodegenerative movement disorder attributed to selective loss of pigmented dopaminergic (DA) neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3847–3857.
Published: 1 October 2006
... is the key regulator of GABAergic neurons, controlling their specification in the dorsal midbrain. Another conclusion from our results is that the function of Mgn shows a previously unrecognized role for h/E(spl) -related transcription factors in the dorsal midbrain GABAergic cell differentiation. Vertebrate...
Includes: Supplementary data