.... and Wieschaus , E. F. ( 2009 ). Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition . Development   136 , 2101 - 2110 . 10.1242/dev.034421 Newport , J. and Kirschner , M. ( 1982a ). A major developmental transition in early xenopus embryos: i...

... could lead to global alteration of the zygotic transcription program early in development. CTCF Cohesin Mid-blastula transition Zebrafish Zygotic genome activation Zygotic genome activation (ZGA) establishes, for the first time in a zygote, a genome that is competent for transcription...

...Junbo Liu; Jun Ma The Drosophila embryo at the mid-blastula transition (MBT) concurrently experiences a receding first wave of zygotic transcription and the surge of a massive second wave. It is not well understood how genes in the first wave become turned off transcriptionally and how...

...Xuemin Lu; Jennifer M. Li; Olivier Elemento; Saeed Tavazoie; Eric F. Wieschaus One of the most prominent features at the mid-blastula transition (MBT)observed in most embryos is a pause in cell cycle regulated by the nucleocytoplasmic (N/C) ratio. By using chromosome rearrangements to manipulate...

... a mid-blastula transition from maternal to embryonic control of development. In addition, we find that embryonic genes tend to be expressed transiently on a time scale consistent with developmental decisions being made with each cell cycle. Furthermore, overall rates of synthesis and degradation...