... brain infection, is associated with an increased risk of neuropsychiatric disorders in affected offspring. The cell types mediating the fetal brain response to maternal inflammation are largely unknown, hindering the development of novel treatment strategies. Here, we show that microglia, the resident...

...Linh Thi My Nguyen; Shaoli Hassan; Hongru Pan; Shuting Wu; Zilong Wen ABSTRACT In vertebrates, the central nervous system (CNS) harbours various immune cells, including parenchymal microglia, perivascular macrophages and dendritic cells, which act in coordination to establish an immune network...

... in microglial phagocytosis while also completing a subset of phagocytic events. Müller glia actively engage with dying cells through initial target cell contact and phagocytic cup formation, after which an exchange of the dying cell from Müller glia to microglia often takes place. In addition, we find evidence...

...Heithem M. El-Hodiri; James R. Bentley; Alana G. Reske; Olivia B. Taylor; Isabella Palazzo; Warren A. Campbell; Nicklaus R. Halloy; Andy J. Fischer ABSTRACT Recent studies have demonstrated the impact of pro-inflammatory signaling and reactive microglia/macrophages on the formation of Müller glial...

...Ivan Mestres; Federico Calegari ABSTRACT Communication between the nervous and immune system is crucial for development, homeostasis and response to injury. Before the onset of neurogenesis, microglia populate the central nervous system, serving as resident immune cells over the course of life...

...Gopalan Gnanaguru; Steven J. Tabor; Gracia M. Bonilla; Ruslan Sadreyev; Kentaro Yuda; Jörg Köhl; Kip M. Connor ABSTRACT Microglia, a resident immune cell of the central nervous system (CNS), play a pivotal role in facilitating neurovascular development through mechanisms that are not fully...

... in the front line of innate brain immune response. Venus and mCherry knock-in mice exhibited expression of RTL5-mCherry and RTL6-Venus fusion proteins in microglia and appeared as extracellular dots and granules in the central nervous system. These proteins display a rapid response to pathogens...

... monocytes, and in some tissues are self-maintained independently of general circulation at a steady state. In this article, we briefly discuss the ontogeny, maintenance and unique tissue adaptions of RTMs focusing on microglia, Kupffer cells, Langerhans cells, intestinal macrophages, cardiac macrophages...

...Lindsey C. Mehl; Amritha V. Manjally; Ouzéna Bouadi; Erin M. Gibson; Tuan Leng Tay ABSTRACT It has recently emerged that microglia, the tissue-resident macrophages of the central nervous system, play significant non-innate immune roles to support the development, maintenance, homeostasis and repair...

...Giuliano Ferrero; Magali Miserocchi; Elodie Di Ruggiero; Valérie Wittamer ABSTRACT In vertebrates, the ontogeny of microglia, the resident macrophages of the central nervous system, initiates early during development from primitive macrophages. Although murine embryonic microglia then persist...

... and whether these effects contribute to neurodegeneration in Niemann–Pick disease type C (NPC). Degeneration of cerebellar Purkinje cells occurs at an earlier stage and to a greater extent in NPC; therefore, we analyzed the effect of NPC1 deficiency on microglia and on climbing fiber synaptic refinement...

...Chiara Herzog; Laura Pons Garcia; Marcus Keatinge; David Greenald; Christian Moritz; Francesca Peri; Leah Herrgen ABSTRACT Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death. Microglia, the resident macrophages of the brain, react to injury by migrating...

... are microglia, suggesting that defective Hoxb8 microglia caused the disorder. What is the source of the Hoxb8 microglia? It has been posited that all microglia progenitors arise at embryonic day (E) 7.5 during yolk sac hematopoiesis, and colonize the brain at E9.5. In contrast, we show the presence of two...

... that the innate immune system can be studied in isolation of the adaptive immune system, because the latter is not functional at early larval stages ( Danilova and Steiner, 2002 ; Lam et al., 2004 ). Hence, microglia/macrophages are positive regulators of lesion-induced neurogenesis in the lesioned adult...

.... Published by The Company of Biologists Ltd 2015 Summary: This poster article reviews the origins of glia, their diverse roles during neural development and their contribution to plasticity and disease in the adult mammalian nervous system. Astrocyte Glia Microglia Myelination Nervous...