... protein family member doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system. Vascular basement membrane Microenvironment Neurovascular unit Extracellular matrix...

... distinct interstitial cell types of distinct lineages. Although frequently referred to as a homogeneous population of cells that functions primarily as a scaffold, several recent studies have shown that, in various systems, the interstitium sets up unique microenvironmental niches that direct tissue...

... adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide...

... the extracellular signals needed for epithelial cells to invade. These recent observations provide strong evidence that MMPs are important not only for ECM remodeling but also for the microenvironmental signaling necessary for morphogenic programs within the mammary gland. To unravel the mechanisms underlying...

...Kalpana Makhijani; Brandy Alexander; Tsubasa Tanaka; Eric Rulifson; Katja Brückner Interactions of hematopoietic cells with their microenvironment control blood cell colonization, homing and hematopoiesis. Here, we introduce larval hematopoiesis as the first Drosophila model for hematopoietic...

...Willem van Ewijk; Georg Holländer; Cox Terhorst; Baoping Wang ABSTRACT T-cell development is under the tight control of thymic microenvironments. Conversely, the integrity of thymic microenvironments depends on the physical presence of developing thymocytes, a phenomenon designated as ‘thymic...