... the maturing gut lumen upon hatching, after which the microbiome associated with these larvae diverges from the environmental microbiota through, what is hypothesized to be, a host-mediated selection. Many of these microbial cells then remain associated with the host after metamorphosis ( Carrier and Reitzel...

...Scott A. Keith; Cassandra Bishop; Samantha Fallacaro; Brooke M. McCartney ABSTRACT Perturbations to animal-associated microbial communities (the microbiota) have deleterious effects on various aspects of host fitness, but the molecular processes underlying these impacts are poorly understood. Here...

... the mechanisms by which microbiota influence host tissues remain unclear. We showed previously that the microbiota is required for allocation of appropriate numbers of secretory cells in the zebrafish intestinal epithelium. Because Notch signaling is crucial for secretory fate determination, we conducted...