... in miR427 recognition sites, a conserved microRNA that destabilizes maternal transcripts including REST, which encodes a Kruppel-type zinc finger transcription factor that we demonstrate is critical for ectodermal cell fates. Mechanistically, we show that Nup107 is required to prevent the premature export...

.../ Summary: In chick, miR-137 shapes neural plate border development by regulating TFAP2A expression, and is itself regulated by DNMT3A-mediated non-canonical methylation, shedding light on crucial epigenetic mechanisms in vertebrate embryos. microRNA Neural plate border Tfap2a DNA methylation miR...

... sequencing, we discovered dynamic changes in poly(A) length through deadenylation and re-polyadenylation. Deadenylation appeared to be mediated by microRNAs (miRNAs), and transcripts with shorter poly(A) tails tend to be sequestered into ribonucleoprotein (RNP) granules for translational repression...

... development is affected by maternal conditions through microRNAs (miRNAs), a group of short noncoding RNAs. Here, we show that miR-129-5p and miR-340-5p suppress cell proliferation in both primary mouse embryonic palatal mesenchymal cells and O9-1 cells, a neural crest cell line, through the regulation...

...Huanqing Zhang; Pei Zhuang; Ryan M. Welchko; Manhong Dai; Fan Meng; David L. Turner ABSTRACT The mammalian retina contains a complex mixture of different types of neurons. We find that microRNA miR-216b is preferentially expressed in postmitotic retinal amacrine cells in the mouse retina...

... defects. Here, we propose the first developmental stage-specific network approach by integrating two crucial regulators, transcription factors (TFs) and microRNAs (miRNAs), to study their co-regulation during craniofacial development. Specifically, we used TFs, miRNAs and non-TF genes to form feed-forward...

... protein to enable accumulation of yolk protein in oocytes during vitellogenesis. MicroRNA Transgene Oogenesis Vitellogenin receptor Bombyx mori National Natural Science Foundation of China 10.13039/501100001809 31530071 WQ 20125500074 An inherently high reproductive...

...Orkan Ilbay; Victor Ambros ABSTRACT MicroRNAs target complementary mRNAs for degradation or translational repression, reducing or preventing protein synthesis. In Caenorhabditis elegans , the transcription factor HBL-1 (Hunchback-like 1) promotes early larval (L2)-stage cell fates, and the let-7...

...Daria Bloch; Malikarjuna Rao Puli; Assaf Mosquna; Shaul Yalovsky ABSTRACT Patterning of the root xylem into protoxylem (PX) and metaxylem is regulated by auxin-cytokinin signaling and microRNA miR165a/166b -mediated suppression of genes encoding Class III HOMEODOMAIN LEU-ZIPPER (HD-ZIPIII) proteins...

... of the germ cell fate. Germ cell Germ plasm microRNA Transcriptional repression Maternal-to-zygotic transition Japan Society for the Promotion of Science 10.13039/501100011746 20112002 26114508 25650088 15K14530 17H03686 NOVARTIS Foundation (Japan) for the Promotion...

...Delfina A. Ré; Patricia L. M. Lang; Cristian Yones; Agustin L. Arce; Georgina Stegmayer; Diego Milone; Pablo A. Manavella ABSTRACT Plants use molecular mechanisms to sense temperatures, trigger quick adaptive responses and thereby cope with environmental changes. MicroRNAs (miRNAs) are key...

... been extensively studied, little is known about its regulation at the post-transcriptional level. Using the migratory locust Locusta migratoria as a model system, we report here that the microRNAs let-7 and miR-278 bound to the Kr-h1 coding sequence and downregulated its expression. Application of let...

...Richard Kaschula; Sofia Pinho; Claudio R. Alonso ABSTRACT Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulation...

... cartilage volume is poorly understood. Here, we provide evidence that Erk signaling during synovial joint development determines articular cartilage thickness in adult mice. Articular cartilage Kras Erk let-7 Lin28 MicroRNA Osteoarthritis National Institutes of Health 10.13039...

...Moritz Sander; Teresa Eichenlaub; Héctor Herranz ABSTRACT Tissue growth has to be carefully controlled to generate well-functioning organs. MicroRNAs are small non-coding RNAs that modulate the activity of target genes and play a pivotal role in animal development. Understanding the functions...

... translation MicroRNA Vesicular transport Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 501100001711 Neural circuits are the basis of neural function in health and disease, and the faulty assembly or disintegration of these circuits can result in disorders...

... photoreceptor RTK signaling MicroRNA National Institutes of Health 10.13039/100000002 R01-EY025598 R01-EY026217 R01-NS074037 R01-NS083833 R01-GM083300 P30-CA008748 Burroughs Wellcome Fund 10.13039/100000861 Memorial Sloan-Kettering Cancer Center 10.13039/100007052...

...Alireza Paikari; Cassandra D. Belair; Daniel Saw; Robert Blelloch The vertebrate-specific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302. The miR-302 locus is found broadly among vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria...

... Article: New alleles of a wheat AP2 gene, Q , define new roles for Q in inflorescence architecture, including the formation and structure of grain-producing spikelets. See also Debernardi et al. in this issue. Wheat Spike Inflorescence AP2 Domestication microRNA The causal molecular...

...Elijah J. Spina; Elmer Guzman; Hongjun Zhou; Kenneth S. Kosik; William C. Smith Here we present a parallel study of mRNA and microRNA expression during oral siphon (OS) regeneration in Ciona robusta , and the derived network of their interactions. In the process of identifying 248 mRNAs and 15...