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Keywords: Mice
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev197673.
Published: 27 April 2021
.... Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter During pregnancy, the mammalian endocrine system promotes maternal metabolic adaptations including enhanced storage of nutrients during the first two-thirds and subsequent acceleration of trans-placental nutrient transport...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (7): dev196295.
Published: 15 April 2021
... associated with their structure formation and mRNA fate regulation during spermatogenesis remains unclear. Here, we show that mitofusin 2 (MFN2), a mitochondrial fusion protein, interacts with nuage-associated proteins (including MIWI, DDX4, TDRKH and GASZ) in mice. Conditional mutation of Mfn2 in postnatal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184507.
Published: 6 April 2020
... and myoblast pools. We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors and myoblasts is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon loss of MyHC-emb function in vitro . Adult Myh3 null mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2719–2724.
Published: 1 August 2015
...-cell level. Endothelium Imaging RUNX1 SOX17 Mice Human Hemogenic Hematopoiesis Endothelial-to-hematopoietic transition Scanning electron microscopy Endothelial-to-hematopoietic transition (EHT) during embryogenesis provides the first long-term hematopoietic stem and progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1694–1704.
Published: 15 April 2014
... Replication stress Mice The transition from meiosis to mitosis is a crucial period in animal life. Although extensively studied it is not yet completely understood. Mammalian oocytes and early embryos contain atypical nucleoli [termed nucleolus precursor bodies (NPBs)]. Unlike somatic cell nucleoli...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3597–3606.
Published: 1 November 2009
...), but the function of talin 2 in skeletal muscle is not known. Here we show that MTJ integrity is affected in talin 2-deficient mice. Concomitant ablation of talin 1 and 2 leads to defects in myoblast fusion and sarcomere assembly, resembling defects in muscle lacking β1 integrins. Talin 1/2-deficient myoblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3617–3626.
Published: 1 November 2009
... School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670,Japan 1 9 2009 © 2009. 2009 Fibroblast growth factors Fgf17 Inferior colliculus Mice A fundamental question in developmental biology is how distinct structures are induced by a single...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2451–2462.
Published: 15 May 2005
..., an early event upon which all subsequent morphogenesis depends. Additional roles for Tbx20 in adult heart integrity and contractile function were revealed by in-vivo cardiac functional analysis of Tbx20 heterozygous mutant mice. These data suggest that mutations in human cardiac transcription factor genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2841–2852.
Published: 15 June 2004
... for correspondence (e-mail: bloch-gallego@cochin.inserm.fr ) * These authors contributed equally to this work 9 3 2004 © 2004. 2004 Nuclear translocation Hindbrain Chemotropic molecules Rho GTPases Mice Collagen assays In situ hybridization GST-RBD-Rhotekin During...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (6): 1437–1448.
Published: 15 March 2004
.... In this study, we generated mice lacking Ccm1 and demonstrate that Ccm1 is ubiquitously expressed early in embryogenesis and is essential for vascular development. Homozygous mutant embryos die in mid-gestation and the first detectable defects are exclusively vascular in nature. The precursor vessels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (19): 4741–4750.
Published: 1 October 2003
... of nerve fibres at the base in adult mutants. Measurements of auditory brain stem responses of these mice revealed a significant hearing loss. The observed innervation patterns correlate with opposing gradients of Bdnf and Nt3 expression in cochlear neurones along the tonotopic axis. Thus, the reshaping...