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Keywords: Mice
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev197673.
Published: 27 April 2021
.... Circadian clock Mice Placenta Trophoblast Xenobiotic efflux transporter During pregnancy, the mammalian endocrine system promotes maternal metabolic adaptations including enhanced storage of nutrients during the first two-thirds and subsequent acceleration of trans-placental nutrient transport...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (7): dev196295.
Published: 15 April 2021
... associated with their structure formation and mRNA fate regulation during spermatogenesis remains unclear. Here, we show that mitofusin 2 (MFN2), a mitochondrial fusion protein, interacts with nuage-associated proteins (including MIWI, DDX4, TDRKH and GASZ) in mice. Conditional mutation of Mfn2 in postnatal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184507.
Published: 06 April 2020
... myoblast pools. We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors and myoblasts is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon loss of MyHC-emb function in vitro . Adult Myh3 null mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2719–2724.
Published: 01 August 2015
... Company of Biologists Ltd 2015 Summary: Correlative microscopy (scanning electron microscopy and SOX17/RUNX1 immunofluorescence) reveals morphological changes during human and mouse endothelial to hematopoietic transition at the single-cell level. Endothelium Imaging RUNX1 SOX17 Mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1694–1704.
Published: 15 April 2014
... authors declare no competing financial interests 12 11 2013 24 2 2014 © 2014. Published by The Company of Biologists Ltd 2014 Nucleolus precursor body Centromere Chromosome bridging Satellite DNA Replication stress Mice The transition from meiosis to mitosis is a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3597–3606.
Published: 01 November 2009
... function of talin 2 in skeletal muscle is not known. Here we show that MTJ integrity is affected in talin 2-deficient mice. Concomitant ablation of talin 1 and 2 leads to defects in myoblast fusion and sarcomere assembly, resembling defects in muscle lacking β1 integrins. Talin 1/2-deficient myoblasts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3617–3626.
Published: 01 November 2009
... Fgf8 signaling is key to patterning of the mid/hindbrain region. By extrapolation, the length of Fgf8 expression could be crucial to Fgf8 function in other embryonic organizers. Fibroblast growth factors Fgf17 Inferior colliculus Mice A fundamental question in developmental biology is how...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2451–2462.
Published: 15 May 2005
... forming heart, an early event upon which all subsequent morphogenesis depends. Additional roles for Tbx20 in adult heart integrity and contractile function were revealed by in-vivo cardiac functional analysis of Tbx20 heterozygous mutant mice. These data suggest that mutations in human cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (12): 2841–2852.
Published: 15 June 2004
... authors contributed equally to this work 9 3 2004 © 2004. 2004 Nuclear translocation Hindbrain Chemotropic molecules Rho GTPases Mice Collagen assays In situ hybridization GST-RBD-Rhotekin Immunohistochemistry on cryosections was performed in phosphate buffered...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (6): 1437–1448.
Published: 15 March 2004
... study, we generated mice lacking Ccm1 and demonstrate that Ccm1 is ubiquitously expressed early in embryogenesis and is essential for vascular development. Homozygous mutant embryos die in mid-gestation and the first detectable defects are exclusively vascular in nature. The precursor vessels of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (19): 4741–4750.
Published: 01 October 2003
... and loss of nerve fibres at the base in adult mutants. Measurements of auditory brain stem responses of these mice revealed a significant hearing loss. The observed innervation patterns correlate with opposing gradients of Bdnf and Nt3 expression in cochlear neurones along the tonotopic axis. Thus...