... regions (DMRs) are demethylated in reset conditions ( Fig. 5 E), in line with previous findings ( Pastor et al., 2016 ). Fig. 5. Methylome analysis of reset PSCs. (A) Bean plots showing the global distribution of CpG methylation levels from pooled replicates of the indicated samples compared...

... or extraembryonic cues. In these simple conditions autocrine signals are sufficient to drive transcriptomic, metabolic and methylome changes that are broadly convergent with peri-implantation epiblast. These findings indicate that the gene regulatory circuitry of ES cells has an innate capacity to orchestrate...