... ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2 gbx1 fgf8 The developing central nervous system is compartmentalized at the neural tube stage into discrete units, so-called...

...2005. 2005 Isthmus Lmx1b Mesencephalon Metencephalon Pax Wnt Zebrafish The cerebellum and tectum develop in response to signals emanating from an organizer located at the isthmus, a constriction of the neural tube that forms between the mesencephalic and metencephalic vesicles...

...Candace L. Chi; Salvador Martinez; Wolfgang Wurst; Gail R. Martin Numerous studies have demonstrated that the midbrain and cerebellum develop from a region of the early neural tube comprising two distinct territories known as the mesencephalon (mes) and rostral metencephalon (met; rhombomere 1...

...Tatsuya Sato; Isato Araki; Harukazu Nakamura The mes/metencephalic boundary (isthmus) has an organizing activity for mesencephalon and metencephalon. The candidate signaling molecule is Fgf8 whose mRNA is localized in the region where the cerebellum differentiates. Responding to this signal...

...Kirk A. Adams; Jennifer M. Maida; Jeffrey A. Golden; Robert D. Riddle ABSTRACT Cells in the caudal mesencephalon and rostral metencephalon become organized by signals emanating from the isthmus organizer (IsO). The IsO is associated with the isthmus, a morphological constriction of the neural tube...