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1-8 of 8
Keywords: Metalloprotease
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Journal Articles
Journal:
Development
Development (2010) 137 (14): 2417–2426.
Published: 15 July 2010
.... In a screen for genes involved in Slit-Robo repulsion, we have identified the Adam family metalloprotease Kuzbanian (Kuz). Kuz does not regulate midline repulsion through cleavage of Slit, nor is Slit cleavage essential for repulsion. Instead, Kuz acts in neurons to regulate repulsion and Kuz can cleave...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2006) 133 (20): 4035–4044.
Published: 15 October 2006
... gene encoding a secreted metalloprotease. Ectopic expression of Tlr1 in several tissues of piranha mutants, including hemocytes, completely restores the wild-type innervation pattern, indicating that Tlr1 functions cell non-autonomously. We further show that loss-of-function mutants of related...
Journal Articles
Carine Le Goff, Robert P. T. Somerville, Frederic Kesteloot, Kimerly Powell, David E. Birk, Alain C. Colige, Suneel S. Apte
Journal:
Development
Development (2006) 133 (8): 1587–1596.
Published: 15 April 2006
... into collagen biosynthesis and the pathobiology of dermatosparaxis. ADAMTS Metalloprotease Procollagen Dermatosparaxis Ehlers-Danlos syndrome The lung was the most prominent site of developmental expression of Adamts2 , where its distribution corresponded with that of Col3a1 ( Fig...
Journal Articles
Journal:
Development
Development (2004) 131 (23): 6001–6008.
Published: 1 December 2004
...M. Wayne Davis; Andrew J. Birnie; Aubrey C. Chan; Antony P. Page; Erik M. Jorgensen Molting is required for progression between larval stages in the life cycle of nematodes. We have identified four mutant alleles of a Caenorhabditis elegans metalloprotease gene, nas-37 , that cause incomplete...
Journal Articles
Journal:
Development
Development (1999) 126 (14): 3119–3130.
Published: 15 July 1999
... inhibitors of Bmps, such as Chordin, Noggin and Follistatin, are implicated in dorsal mesodermal and neural development. We investigated the role of Tolloid, a metalloprotease that can cleave Chordin and increase Bmp activity, in patterning the dorsoventral axis of the zebrafish embryo. Injection of tolloid...
Journal Articles
Journal:
Development
Development (1997) 124 (23): 4759–4767.
Published: 1 December 1997
... of metalloproteases. SUP-17 is highly similar to Drosophila KUZBANIAN, which functions in Drosophila neurogenesis, and the vertebrate ADAM10 protein. Furthermore, we show by genetic analysis that the extracellular domain of LIN-12 appears to be necessary for sup-17 to facilitate lin-12 signalling and that sup-17 does...
Journal Articles
Journal:
Development
Development (1997) 124 (23): 4769–4779.
Published: 1 December 1997
..., Cambridge CB2 1QR, UK † Author for correspondence (e-mail: [email protected] ) 25 09 1997 © 1997 by Company of Biologists 1997 The sequence of the Kuz molecule indicates that it harbours a metalloprotease center located in the extracellular domain of the protein ( Rooke et...
Journal Articles
Journal:
Development
Development (1992) 114 (1): 147–163.
Published: 1 January 1992
...: a signal peptide, a putative propeptide, a catalytic domain with an active center typical of a Zn 2+ -metalloprotease, an EGF-like domain and two internal repeats similar to repeated domains found in the Cis and Clr serine proteases of the complement cascade. The BP10 protease is constructed with the same...