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Keywords: Metabolism
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200277.
Published: 19 May 2022
...Hannah Brunsdon; Alessandro Brombin; Samuel Peterson; John H. Postlethwait; E. Elizabeth Patton ABSTRACT Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200491.
Published: 28 March 2022
... and whole-body glycogen and protein. In males, the low-sugar diet augmented insulin/insulin-like growth factor signalling pathway (IIS) activity by increasing insulin sensitivity, where increased IIS was required for male metabolic and body size responses in 0S. In females reared on low sugar, IIS activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev195222.
Published: 29 July 2021
..., we identify a connection between the microbiota and the neuronal factor Arc1 that affects growth and metabolism in Drosophila . We find that Arc1 exhibits tissue-specific microbiota-dependent expression changes, and that germ-free flies bearing a null mutation of Arc1 exhibit delayed and stunted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199609.
Published: 12 June 2021
...Lluc Mosteiro; Hanaa Hariri; Jelle van den Ameele ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev193417.
Published: 30 November 2020
... network in the adult heart despite partial transcriptional re-activation of a neonatal glycolytic gene programme. These findings suggest that β-catenin might be repurposed from regenerative to protective functions in the adult heart in a developmental process dependent on the metabolic status...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev182675.
Published: 3 August 2020
..., which can be an acquired rather than a hardwired intrinsic property. In this Review, we summarise the recent findings into how ISC identity can be defined by proliferation state, signalling crosstalk, epigenetics and metabolism, and propose an update on the hallmarks of ISCs. We further discuss how...
Journal Articles
Journal: Development
Development (2020) 147 (11): dev189340.
Published: 14 June 2020
... of the current renaissance in metabolic research. Amidst the global rise in metabolic syndrome, the discovery of novel signaling roles for metabolites, and the increasing links between altered metabolism and many human diseases, we as developmental biologists can contribute skills and expertise that are uniquely...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev186213.
Published: 30 March 2020
... signaling downstream of GLP1R is activated by glucagon, or whether islet cells are the sole target of GLP-1 signaling in the fetal pancreas. Further studies of endogenous GLP-1 signaling in pig fetal islet development could also clarify the emerging concept of intra-islet GLP-1 signaling in metabolically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev182857.
Published: 24 October 2019
... that MYC regulates the changing ribosomal and proteostatic landscapes in mouse forebrain precursors at embryonic days E8.5 and E10.5 (before and after neural tube closure; NTC) ( Chau et al., 2018 ). Here, we demonstrate parallel coordinated transcriptional changes in metabolic machinery during this same...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev168997.
Published: 22 October 2018
...Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey ABSTRACT As human pluripotent stem cells (hPSCs) exit pluripotency, they reportedly switch from glycolytic energy production to primarily mitochondrial metabolism. Here, we show that upon ectoderm differentiation to neural precursor cells (NPCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161786.
Published: 7 September 2018
..., as well as in somatic tissues, challenging dogma in the piRNA field. In this Review, we focus on recent data addressing the biological and developmental functions of piRNAs, highlighting their roles in embryonic patterning, germ cell specification, stem cell biology, neuronal activity and metabolism...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev152595.
Published: 8 January 2018
...Delong Meng; Anderson R. Frank; Jenna L. Jewell ABSTRACT The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3193–3198.
Published: 15 September 2017
...Alena Krejci; Jason M. Tennessen Despite the fact that metabolic studies played a prominent role in the early history of developmental biology research, the field of developmental metabolism was largely ignored following the advent of modern molecular biology. Metabolism, however, has recently re...
Journal Articles
Journal: Development
Development (2017) 144 (17): 3007–3011.
Published: 1 September 2017
... The authors declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 References Brunet , A. and Rando , T. A. ( 2017 ). Interaction between epigenetic and metabolism in aging stem cells . Curr. Opin. Cell Biol.   45 , 1 - 7 . 10.1016...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1201–1210.
Published: 1 April 2017
..., Hemicentrotus pulcherrimus . Dev. Growth Differ   32 , 145 - 156 . 10.1111/j.1440-169X.1990.00145.x Valcourt , J. R. , Lemons , J. M. S. , Haley , E. M. , Kojima , M. , Demuren , O. O. and Coller , H. A. ( 2012 ). Staying alive: metabolic adaptations to quiescence . Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1018–1024.
Published: 15 March 2017
... highlights the specific requirements in stem cell metabolism for expanding organ progenitors during organogenesis and regeneration. Here, transcriptome analyses show that progenitors of the mouse and human liver bud growth stage specifically express the gene branched chain aminotransferase 1, encoding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3050–3060.
Published: 1 September 2016
...Jason S. L. Yu; Wei Cui Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions...
Journal Articles
Journal: Development
Development (2016) 143 (17): 3045–3049.
Published: 1 September 2016
...Aurelio A. Teleman It is becoming increasingly clear that cellular metabolite levels regulate the activity of signaling pathways, and conversely that signaling pathways affect cellular physiology and growth via metabolic pathways. Thus, metabolism and signaling mutually influence each other...
Journal Articles
Journal: Development
Development (2015) 142 (7): 1228–1241.
Published: 1 April 2015
...-Seq analyses of FACS-isolated wild-type and Six2(GFP + ) CM cells revealed that the top downregulated genes in Six2Cre + ;p53 fl/fl CM belong to glucose metabolism and adhesion and/or migration pathways. Mutant cells exhibit a ∼50% decrease in ATP levels and a 30% decrease in levels of reactive oxygen...
Includes: Supplementary data