1-20 of 21
Keywords: Metabolism
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (8): dev199026.
Published: 16 April 2021
...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev193417.
Published: 30 November 2020
... network in the adult heart despite partial transcriptional re-activation of a neonatal glycolytic gene programme. These findings suggest that β-catenin might be repurposed from regenerative to protective functions in the adult heart in a developmental process dependent on the metabolic status of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev182675.
Published: 03 August 2020
... cellular states, which can be an acquired rather than a hardwired intrinsic property. In this Review, we summarise the recent findings into how ISC identity can be defined by proliferation state, signalling crosstalk, epigenetics and metabolism, and propose an update on the hallmarks of ISCs. We further...
Journal Articles
Journal: Development
Development (2020) 147 (11): dev189340.
Published: 14 June 2020
... the current renaissance in metabolic research. Amidst the global rise in metabolic syndrome, the discovery of novel signaling roles for metabolites, and the increasing links between altered metabolism and many human diseases, we as developmental biologists can contribute skills and expertise that are...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev186213.
Published: 30 March 2020
...: Transcriptional, signaling and cellular programs governing pig pancreatic islet development exhibit striking similarities to human islet ontogeny, providing a novel resource for advancing human islet replacement strategies. Pancreas Metabolism Organogenesis β-Cell α-Cell δ-cell Diabetes mellitus Pig...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev182857.
Published: 24 October 2019
... that MYC regulates the changing ribosomal and proteostatic landscapes in mouse forebrain precursors at embryonic days E8.5 and E10.5 (before and after neural tube closure; NTC) ( Chau et al., 2018 ). Here, we demonstrate parallel coordinated transcriptional changes in metabolic machinery during this...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev168997.
Published: 22 October 2018
...Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey ABSTRACT As human pluripotent stem cells (hPSCs) exit pluripotency, they reportedly switch from glycolytic energy production to primarily mitochondrial metabolism. Here, we show that upon ectoderm differentiation to neural precursor cells (NPCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161786.
Published: 07 September 2018
... well as in somatic tissues, challenging dogma in the piRNA field. In this Review, we focus on recent data addressing the biological and developmental functions of piRNAs, highlighting their roles in embryonic patterning, germ cell specification, stem cell biology, neuronal activity and metabolism...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev152595.
Published: 08 January 2018
...Delong Meng; Anderson R. Frank; Jenna L. Jewell ABSTRACT The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3193–3198.
Published: 15 September 2017
...Alena Krejci; Jason M. Tennessen Despite the fact that metabolic studies played a prominent role in the early history of developmental biology research, the field of developmental metabolism was largely ignored following the advent of modern molecular biology. Metabolism, however, has recently re...
Journal Articles
Journal: Development
Development (2017) 144 (17): 3007–3011.
Published: 01 September 2017
... this 2017 EMBO Conference. Stem cell Regenerative medicine Epigenetics Metabolism Regulation Organogenesis One of the ultimate goals of stem cell biologists is to learn more about the development, homeostasis and regeneration of organisms, and to apply this knowledge to understand...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1201–1210.
Published: 01 April 2017
... by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Highlighted article: Multiple mechanisms induce quiescence of translation in sea urchin primordial germ cells, including Nanos2-mediated downregulation of eIF1A and a switch to glycolytic metabolism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (6): 1018–1024.
Published: 15 March 2017
... highlights the specific requirements in stem cell metabolism for expanding organ progenitors during organogenesis and regeneration. Here, transcriptome analyses show that progenitors of the mouse and human liver bud growth stage specifically express the gene branched chain aminotransferase 1, encoding a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3050–3060.
Published: 01 September 2016
...Jason S. L. Yu; Wei Cui Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are...
Journal Articles
Journal: Development
Development (2016) 143 (17): 3045–3049.
Published: 01 September 2016
...Aurelio A. Teleman It is becoming increasingly clear that cellular metabolite levels regulate the activity of signaling pathways, and conversely that signaling pathways affect cellular physiology and growth via metabolic pathways. Thus, metabolism and signaling mutually influence each other. The...
Journal Articles
Journal: Development
Development (2015) 142 (7): 1228–1241.
Published: 01 April 2015
... hypertension. RNA-Seq analyses of FACS-isolated wild-type and Six2(GFP + ) CM cells revealed that the top downregulated genes in Six2Cre + ;p53 fl/fl CM belong to glucose metabolism and adhesion and/or migration pathways. Mutant cells exhibit a ∼50% decrease in ATP levels and a 30% decrease in levels of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4206–4218.
Published: 15 November 2014
... suggests that this balance is partly regulated by reactive oxygen species (ROS), which, in synchrony with metabolism, mediate the cellular redox state. In this Primer, we summarize what ROS are and how they are generated in the cell, as well as their downstream molecular targets. We then review recent...
Journal Articles
Journal: Development
Development (2013) 140 (17): 3601–3612.
Published: 01 September 2013
...Christopher M. Webster; Lianfeng Wu; Denzil Douglas; Alexander A. Soukas The target of rapamycin complex 2 (TORC2) pathway is evolutionarily conserved and regulates cellular energetics, growth and metabolism. Loss of function of the essential TORC2 subunit Rictor (RICT-1) in Caenorhabditis elegans...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3079–3093.
Published: 01 August 2013
... addition to their well-established function in cell cycle control, it is becoming increasingly apparent that mammalian Cdks, cyclins and CKIs play indispensable roles in processes such as transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions and spermatogenesis. Even...
Journal Articles
Journal: Development
Development (2008) 135 (1): 111–121.
Published: 01 January 2008
... that these factors control cumulus cell metabolism, particularly glycolysis and cholesterol biosynthesis before the preovulatory surge of luteinizing hormone. Transcripts encoding enzymes for cholesterol biosynthesis were downregulated in both Bmp15 -/- and Bmp15 -/- Gdf9 +/- double mutant cumulus...
Includes: Supplementary data