... markers associated with EMT. EMT MET Cancer metastasis Developmental models Epithelium Mesenchyme Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial transition (MET) are dynamic processes – collectively referred to as EMTs – that are associated...

... epiblast cellular morphology and its pluripotency is not well understood. Here, using chicken epiblast and mammalian pluripotency stem cell (PSC) models, we show that PSCs undergo a mesenchymal-epithelial transition (MET) prior to EMT-associated pluripotency loss. Epiblast MET and its subsequent EMT...

... exogenous Oct4, Sox2, Klf4 and c-Myc (OSKM) and endogenous SOX2 and NANOG. iRSCs can be stably maintained at low density. At high density, however, they are induced to enter mesenchymal-epithelial transition (MET), resulting in reprogramming to an iPSC state. Morphological changes through MET correlate...

... into tubules called nephrons. Each of these cell types arise during embryonic development from a mesenchymal stem cell pool through a process of mesenchymal-to-epithelial transition (MET) that requires sequential action of specific Wnt signals. Induction by Wnt9b directs cells to exit the stem cell niche...

... . The antagonizing effect of JH on 20E-induced PCD in the fat body was further confirmed in the JH-deficient animals by 20E treatment and RNA interference of the 20E receptor EcR . Moreover, MET and GCE, the bHLH-PAS transcription factors involved in JH action, were shown to induce PCD by upregulating Dronc...

... -838. Bhatt, A. S., Erdjument-Bromage, H., Tempst, P., Craik, C. S. and Moasser, M. M. ( 2005 ). Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24 , 5333 -5343. Birchmeier, C. and Gherardi, E. ( 1998 ). Developmental roles of HGF/SF and its receptor, the c-Met...

... are migratory, like limb muscles, by showing that they are absent in met d/d mutants. Using experimental embryological procedures (in chick) and genetic models (in chick and mouse), we show that the development of the cloacal musculature is dependent on proximal leg field formation. Thus, we have discovered...

... in their developmental history to produce appendicular muscle. We further show that this restriction in competence is mirrored at the molecular level, with the exclusive expression of the receptor tyrosine kinase met within somitic regions fated to give rise to appendicular muscle. Loss-of-function experiments reveal...

...Humberto Gutierrez; Xavier Dolcet; Mary Tolcos; Alun Davies Although hepatocyte growth factor (HGF) and its receptor tyrosine kinase MET are widely expressed in the developing and mature central nervous system,little is known about the role of MET signaling in the brain. We have used particle...