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Keywords: Mesp2
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Journal Articles
Journal: Development
Development (2011) 138 (1): 55–64.
Published: 01 January 2011
... suppression of Notch signaling is essential for the establishment of rostro-caudal polarity within a somite and that Mesp2 acts as a novel negative regulator of the Notch signaling pathway. We generated a knock-in mouse in which a dominant-negative form of Rbpj is introduced into the Mesp2 locus. Intriguingly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (9): 1515–1522.
Published: 01 May 2010
... segmented somites are continuously generated, indicating that the NICD on/off state is unnecessary for somite boundary formation. Surprisingly, this mouse also showed a normal rostral-caudal compartment within a somite, conferred by a normal Mesp2 expression pattern with a rostral-caudal gradient. To...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (13): 2517–2525.
Published: 01 July 2006
... segment border formation is the bHLH transcription factor Mesp2, the expression of which is restricted to the anterior PSM. A gene candidate that is activated by Mesp2 is Epha4 , as its expression pattern resembles Mesp2 and is absent in Mesp2-null embryos. We have analyzed the enhancer region of Epha4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 787–796.
Published: 15 February 2005
...Yu Takahashi; Satoshi Kitajima; Tohru Inoue; Jun Kanno; Yumiko Saga Mesp1 and Mesp2 are homologous basic helix-loop-helix (bHLH) transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) just prior to somite formation. Analysis of possible functional redundancy of Mesp1...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4259–4268.
Published: 15 September 2003
...Yu Takahashi; Tohru Inoue; Achim Gossler; Yumiko Saga Elaborate metamerism in vertebrate somitogenesis is based on segmental gene expression in the anterior presomitic mesoderm (PSM). Notch signal pathways with Notch ligands Dll1 and Dll3, and the transcription factor Mesp2 are implicated in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (10): 2473–2481.
Published: 15 May 2002
...Aya Nomura-Kitabayashi; Yu Takahashi; Satoshi Kitajima; Tohru Inoue; Hiroyuki Takeda; Yumiko Saga A bHLH-type transcription factor, Mesp2, plays an essential role in somite segmentation in mice. Zebrafish mespb ( mesp-b ), a putative homologue of mouse Mesp2, is transiently expressed in the rostral...