... of epicardial development reveal a new role for Wt1 in the control of epicardial cell morphology and maturation through regulation of the Bmp4 signalling pathway. Epicardium Wt1 BMP4 Heart morphogenesis Cell shape Mesothelium Mouse Detailed knowledge of the differentiation and maturation...

... such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, although the factors that regulate early lung mesoderm development are unknown. We show in mouse that the PRC2 component Ezh2 is required to restrict smooth muscle differentiation in the developing lung mesothelium. Mesodermal loss...

...Radhika Dixit; Xingbin Ai; Alan Fine Recent studies have shown that mesothelial progenitors contribute to mesenchymal lineages of developing organs. To what extent the overlying mesothelium contributes to lung development remains unknown. To rigorously address this question, we employed Wt1 CreERT2...

...Nichelle I. Winters; Rebecca T. Thomason; David M. Bader Mesothelium is the surface layer of all coelomic organs and is crucial for the generation of their vasculature. Still, our understanding of the genesis of this essential cell type is restricted to the heart where a localized exogenous...

... the mesothelium (the future pleura) to sub-mesothelial mesenchyme through both FGF receptor (FGFR) 1 and FGFR2 to induce proliferation. FGF9 also signals from the epithelium to the sub-epithelial mesenchyme to maintain SHH signaling,which regulates cell proliferation, survival and the expression of mesenchymal...

... outer layer of presumptive mesothelium gradually acquires vascular cell adhesion molecule(VCAM1) and mediates chorio-allantoic union. Intriguingly, the VCAM1 domain does not extend into the proximal allantoic region. How these three allantoic cell types are established is not known, although contact...

... into an outer layer of mesothelium and an inner vascular network begins in the distal region of the allantois, which is most remote from other tissues, as early as the late neural plate stage (approximately 7.75 days postcoitum). Nascent blood vessels were not found in the base of the allantois until 4-somite...