... activation in migrating mesoderm cells. The results support the model that Pyr acts as an instructive cue for mesoderm migration during gastrulation. Consistent with this function, mutations in pyr affect the normal segmental number of cardioblasts. Furthermore, Pyr is essential for the specification of even...

... during mesoderm migration. Genetic and biochemical interactions indicate that during mesoderm migration, Pbl functions by activating a Rac-dependent pathway. Furthermore,gain-of-function and rescue experiments suggest an important regulatory role of the C-terminal tail of Pbl for the selective activation...

..., ectoderm and endoderm ( Kosher and Searls, 1973 ). In chick embryos, precardiac mesoderm migrates across endoderm and this migration can be altered by treatment with anti-fibronectin antibodies or with a RGD-containing peptide ( Linask and Lash, 1986 ; 1988). But, as pointed out earlier, the ability...