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Keywords: Mesenchyme
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev199655.
Published: 4 February 2022
... tissue interactions at key time points in the mouse embryo. We demonstrate the utility of the approach by providing volumetric data, 3D distribution of three main cellular components (epithelial, mesenchymal and endothelial cells) within the developing pancreas, and quantification of their relative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev198036.
Published: 20 April 2021
...Guojun Sheng ABSTRACT Over 50 years after its discovery in early chick embryos, the concept of epithelial-mesenchymal transition (EMT) is now widely applied to morphogenetic studies in both physiological and pathological contexts. Indeed, the EMT field has witnessed exponential growth in recent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
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Reproductive biology
Journal: Development
Development (2019) 146 (20): dev180430.
Published: 18 October 2019
... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4139–4150.
Published: 1 December 2015
... their formation during embryonic development. Here, we show that a population of lipid-droplet-containing stromal cells emerges in the developing mouse lung between E15.5 and E16.5. This is accompanied by significant upregulation, in the lung mesenchyme, of peroxisome proliferator-activated receptor gamma (master...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 2015–2026.
Published: 1 May 2013
... to develop from either the third PP ( Norris, 1938 ) or from both the third and fourth PP ( Van Dyke, 1941 ). As in the mouse, the bilateral human primordia initially each comprise thymic and parathyroid domains, and are encased in a neural crest-derived mesenchymal capsule from early in development. From...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3363–3372.
Published: 15 September 2012
.... We show that pancreatic progenitor-specific ablation of Sox9 during early pancreas development causes pancreas-to-liver cell fate conversion. Sox9 deficiency results in cell-autonomous loss of the fibroblast growth factor receptor (Fgfr) 2b, which is required for transducing mesenchymal Fgf10 signals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2187–2197.
Published: 1 July 2009
... investigate the interaction between the developing epithelium and its surrounding mesenchyme in one such system, the taste papillae and sensory taste buds of the mouse tongue. We identify follistatin (FST) as a mesenchymal factor that controls size, patterning and gustatory cell differentiation in developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 897–903.
Published: 15 March 2009
.... We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results in the formation of ectopic teeth in the diastema, mesial to the first molars. This phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3743–3752.
Published: 15 October 2007
... hedgehog (SHH) signaling to lung mesenchyme, but not to endothelial cells, are each necessary and together sufficient for distal capillary development. Furthermore, both gain- and loss-of-function of FGF9 regulates Vegfa expression in lung mesenchyme, and VEGF signaling is required for FGF9-mediated blood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (10): 1873–1885.
Published: 15 May 2007
... presumptive lens ectoderm, placodal ectoderm and ocular mesenchyme all contribute to lens development. In each case, Pygo2 is required for normal expression levels of the crucial transcription factor Pax6. Finally, we provide multiple lines of evidence that although Pygo2 can function in the Wnt pathway, its...
Journal Articles
Journal: Development
Development (2007) 134 (8): 1509–1518.
Published: 15 April 2007
... in embryos of both species involve inductive events on a single mother cell that result in production of daughters with different cell fates. Here we show in the ascidian Halocynthia roretzi that polarity of muscle/mesenchyme mother precursors is determined solely by the direction from which the FGF9/16/20...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1507–1517.
Published: 15 April 2006
...Andrew C. White; Jingsong Xu; Yongjun Yin; Craig Smith; Gregory Schmid; David M. Ornitz Morphogenesis of the lung is regulated by reciprocal signaling between epithelium and mesenchyme. In previous studies, we have shown that FGF9 signals are essential for lung mesenchyme development. Using Fgf9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3405–3417.
Published: 1 August 2005
... that is sufficient to direct expression throughout the lateral mesoderm, beginning at 7.5 days of mouse embryonic development. The activity of this enhancer is initially broad but eventually becomes restricted to the mesenchyme surrounding the liver. We demonstrate that the function of this enhancer in transgenic...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3537–3548.
Published: 1 August 2005
... Mesenchyme Neural crest Skull Suture Craniosynostosis Bones are formed by one of two types of ossification processes,intramembranous or endochondral bone formation. The neurocranium is composed of membranous bones that are formed by direct ossification, and the sutures between them comprise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3217–3230.
Published: 15 July 2005
... exhibit open-eyelids at birth. To elucidate the roles of FGF10 during eyelid formation, we examined the expression pattern of Fgf10 during eyelid formation and the phenotype of Fgf10- null eyelids in detail. Fgf10 is expressed by mesenchymal cells just beneath the protruding epidermal cells of the nascent...
Journal Articles
Journal: Development
Development (2005) 132 (5): 1127–1136.
Published: 1 March 2005
...Sandra C. Mendes; Catherine Robin; Elaine Dzierzak Mesenchymal stem cells (MSCs) have great clinical potential for the replacement and regeneration of diseased or damaged tissue. They are especially important in the production of the hematopoietic microenvironment,which regulates the maintenance...
Journal Articles
Journal: Development
Development (2005) 132 (5): 1085–1092.
Published: 1 March 2005
...Josefina Edsbagge; Jenny K. Johansson; Farzad Esni; Yang Luo; Glenn L. Radice; Henrik Semb Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from the pancreatic mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas...
Journal Articles
Journal: Development
Development (2003) 130 (21): 5179–5190.
Published: 1 November 2003
..., notochord and mesenchyme are induced in the anterior and posterior margins, respectively, of the vegetal hemisphere by the same FGF signal emanating from endoderm precursors. The difference in the responsiveness depends on the inheritance of the posterior-vegetal egg cytoplasm. We show that macho-1 , first...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4461–4472.
Published: 15 September 2003
...Kaoru S. Imai; Nori Satoh; Yutaka Satou Ascidian larvae develop mesenchyme cells in their trunk. A fibroblast growth factor (FGF9/16/20) is essential and sufficient for induction of the mesenchyme in Ciona savignyi . We have identified two basic helix-loop-helix (bHLH) genes named Twist-like1...