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Keywords: Mesenchyme
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Journal: Development
Development (2024) 151 (8): dev202430.
Published: 23 April 2024
... in mutant lungs with altered expression of marker genes associated with proximal mesenchymal cell types, airway smooth muscle and alveolar duct myofibroblasts. In vitro studies confirmed that Yap/Taz regulates myofibroblast-associated gene signature and contractility. Together, our findings show that Yap...
Includes: Supplementary data
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Journal: Development
Development (2023) 150 (16): dev201827.
Published: 17 August 2023
...Shih-Yun Chen; Fu-Chin Liu ABSTRACT Morphological development of the lung requires complex signal crosstalk between the mesenchymal and epithelial progenitors. Elucidating the genetic cascades underlying signal crosstalk is essential to understanding lung morphogenesis. Here, we identified Nolz1...
Includes: Supplementary data
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Journal: Development
Development (2021) 148 (8): dev198036.
Published: 20 April 2021
...Guojun Sheng ABSTRACT Over 50 years after its discovery in early chick embryos, the concept of epithelial-mesenchymal transition (EMT) is now widely applied to morphogenetic studies in both physiological and pathological contexts. Indeed, the EMT field has witnessed exponential growth in recent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
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Journal: Development
Development (2013) 140 (9): 2015–2026.
Published: 1 May 2013
.... , Ziegler A. , Kelemen E. ( 1986 ). Separate ontogeny of two macrophage-like accessory cell populations in the human fetus . J. Immunol. 136 , 4354 – 4361 . Jenkinson W. E. , Jenkinson E. J. , Anderson G. ( 2003 ). Differential requirement for mesenchyme...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3363–3372.
Published: 15 September 2012
.... We show that pancreatic progenitor-specific ablation of Sox9 during early pancreas development causes pancreas-to-liver cell fate conversion. Sox9 deficiency results in cell-autonomous loss of the fibroblast growth factor receptor (Fgfr) 2b, which is required for transducing mesenchymal Fgf10 signals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2187–2197.
Published: 1 July 2009
... investigate the interaction between the developing epithelium and its surrounding mesenchyme in one such system, the taste papillae and sensory taste buds of the mouse tongue. We identify follistatin (FST) as a mesenchymal factor that controls size, patterning and gustatory cell differentiation in developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 897–903.
Published: 15 March 2009
.... We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, Shh activity is increased in the toothless diastema mesenchyme of the embryonic jaw primordia. This results in the formation of ectopic teeth in the diastema, mesial to the first molars. This phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3743–3752.
Published: 15 October 2007
... hedgehog (SHH) signaling to lung mesenchyme, but not to endothelial cells, are each necessary and together sufficient for distal capillary development. Furthermore, both gain- and loss-of-function of FGF9 regulates Vegfa expression in lung mesenchyme, and VEGF signaling is required for FGF9-mediated blood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (10): 1873–1885.
Published: 15 May 2007
... presumptive lens ectoderm, placodal ectoderm and ocular mesenchyme all contribute to lens development. In each case, Pygo2 is required for normal expression levels of the crucial transcription factor Pax6. Finally, we provide multiple lines of evidence that although Pygo2 can function in the Wnt pathway, its...
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Journal Articles
Journal: Development
Development (2006) 133 (8): 1507–1517.
Published: 15 April 2006
...Andrew C. White; Jingsong Xu; Yongjun Yin; Craig Smith; Gregory Schmid; David M. Ornitz Morphogenesis of the lung is regulated by reciprocal signaling between epithelium and mesenchyme. In previous studies, we have shown that FGF9 signals are essential for lung mesenchyme development. Using Fgf9...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2005) 132 (15): 3537–3548.
Published: 1 August 2005
... Mesenchyme Neural crest Skull Suture Craniosynostosis Bones are formed by one of two types of ossification processes,intramembranous or endochondral bone formation. The neurocranium is composed of membranous bones that are formed by direct ossification, and the sutures between them comprise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3217–3230.
Published: 15 July 2005
... exhibit open-eyelids at birth. To elucidate the roles of FGF10 during eyelid formation, we examined the expression pattern of Fgf10 during eyelid formation and the phenotype of Fgf10- null eyelids in detail. Fgf10 is expressed by mesenchymal cells just beneath the protruding epidermal cells of the nascent...