... cells in the spinal cord were correctly specified, but could not properly mature. By contrast, in the developing mesencephalon, loss of Nato3 did not affect FP differentiation, but led to loss of neurogenic activity in the medial subpopulation of mesFP cells by suppressing proneural gene expression...

...Tomoya Nakatani; Yasuko Minaki; Minoru Kumai; Yuichi Ono The mechanism underlying the determination of neurotransmitter phenotype in the developing mesencephalon, particularly GABAergic versus glutamatergic fate, remains largely unknown. Here, we show in mice that the basic helix-loop-helix...

... ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2 gbx1 fgf8 The developing central nervous system is compartmentalized at the neural tube stage into discrete units, so-called...

...2005. 2005 Isthmus Lmx1b Mesencephalon Metencephalon Pax Wnt Zebrafish The cerebellum and tectum develop in response to signals emanating from an organizer located at the isthmus, a constriction of the neural tube that forms between the mesencephalic and metencephalic vesicles...

... 1 2 2005 ©2005. 2005 Sax1 Emx2 Six3 Pax6 Mesencephalon Tegmentum Medial longitudinal fascicle Posterior commissure Early axon scaffold A characteristic feature of all vertebrates is the formation of a conserved set of longitudinal and commissural axon tracts...

...Candace L. Chi; Salvador Martinez; Wolfgang Wurst; Gail R. Martin Numerous studies have demonstrated that the midbrain and cerebellum develop from a region of the early neural tube comprising two distinct territories known as the mesencephalon (mes) and rostral metencephalon (met; rhombomere 1...

...Tatsuya Sato; Isato Araki; Harukazu Nakamura The mes/metencephalic boundary (isthmus) has an organizing activity for mesencephalon and metencephalon. The candidate signaling molecule is Fgf8 whose mRNA is localized in the region where the cerebellum differentiates. Responding to this signal...

...Kirk A. Adams; Jennifer M. Maida; Jeffrey A. Golden; Robert D. Riddle ABSTRACT Cells in the caudal mesencephalon and rostral metencephalon become organized by signals emanating from the isthmus organizer (IsO). The IsO is associated with the isthmus, a morphological constriction of the neural tube...

...Isato Araki; Harukazu Nakamura Regionalization of a simple neural tube is a fundamental event during the development of central nervous system. To analyze in vivo the molecular mechanisms underlying the development of mesencephalon, we ectopically expressed Engrailed, which is expressed...

... Isthmic organiser centre Wnt1 En2 Pax2 Neural tube Segmentation Cerebellum Mesencephalon Chick/Quail chimera In the last decade, a number of studies using chick/quail transplantation experiments have analysed planar inductive processes in the avian neural tube. Nakamura et al. (1986...

...Scott M. K. Lee; Paul S. Danielian; Bernd Fritzsch; Andrew P. McMahon ABSTRACT The developing vertebrate mesencephalon shows a rostrocaudal gradient in the expression of a number of molecular markers and in the cytoarchitectonic differentiation of the tectum, where cells cease proliferating...

... crest, after the dorsal neural tube was resected at the mesencephalic and rhombencephalic level. We found first that excisions at the 5-somite stage extending from the mid-mesencephalon down to r8 are followed by the regeneration of neural crest cells able to compensate for the deficiencies so produced...