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Keywords: Membrane-anchored serine protease
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Journal Articles

Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM

Open Access
Roman Szabo, Makiko Kawaguchi, Hiroaki Kataoka, Thomas H. Bugge
Journal: Development
Development (2023) 150 (17): dev201801.
https://doi.org/10.1242/dev.201801
Published: 31 August 2023
... , D. E. and Bugge , T. H. (2016). Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin . Development 143 , 2818 - 2828 . 10.1242/dev.137968 Szabo , R. , Callies , L. K. and Bugge , T. H. (2019). Matriptase...
View articletitled, Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM
Open the PDF for Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM in another window
Includes: Supplementary data
Journal Articles

Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy

Free
Roman Szabo, LuLu K. Callies, Thomas H. Bugge
Journal: Development
Development (2019) 146 (22): dev183392.
https://doi.org/10.1242/dev.183392
Published: 18 November 2019
... that overactivation of the membrane-anchored serine protease matriptase in the absence of its inhibitor HAI-2 triggers intestinal failure. Intestinal development Enteropathy Membrane-anchored serine protease Epithelial barrier EpCAM HAI-2 Congenital tufting enteropathy (CTE, OMIM #613217...
View articletitled, Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy
Open the PDF for Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy in another window
Includes: Supplementary data