... of melanoblast proliferation by Aim2 in primary NC cell cultures. These results reveal the Ednrb–Aim2–AKT axis in regulating melanocyte development and suggest that Ednrb signaling functions as a negative regulator of Aim2, which inhibits the proliferation of melanoblasts in early development. These findings...

.... Within the peripheral branch, where absence of retinoic acid resulted in neural crest production and emigration extending into the roof plate stage, sensory progenitors failed to separate from melanocytes, leading to formation of a common glia-melanocyte cell with aberrant migratory patterns. In summary...

...Alessandro Brombin; E. Elizabeth Patton ABSTRACT Melanocytes evolved to produce the melanin that gives colour to our hair, eyes and skin. The melanocyte lineage also gives rise to melanoma, the most lethal form of skin cancer. The melanocyte lineage differentiates from neural crest cells during...

.... References Agarwal , P. , Verzi , M. P. , Nguyen , T. , Hu , J. , Ehlers , M. L. , McCulley , D. J. , Xu , S.-M. , Dodou , E. , Anderson , J. P. , Wei , M. L. , et al. ( 2011 ). The MADS box transcription factor MEF2C regulates melanocyte development...

..., conditional β-catenin inactivation in premigratory neural crest cells abolishes both sensory neuron and melanocyte formation. Intriguingly, the generation of melanocytes is also prevented by activation of β-catenin in the premigratory neural crest, which promotes sensory neurogenesis at the expense of other...

...Hitomi Aoki; Yasuhiro Yamada; Akira Hara; Takahiro Kunisada Unlike the thoroughly investigated melanocyte population in the hair follicle of the epidermis, the growth and differentiation requirements of the melanocytes in the eye, harderian gland and inner ear - the so-called non-cutaneous...

... of neural crest-derived melanocytes in Xenopus. Dev. Biol. 259 , 19 -33. Bang, A. G., Papalopulu, N., Kintner, C. and Goulding, M. D. ( 1997 ). Expression of Pax3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm...

..., because of the difficulty of identifying individual stem cells and their surrounding components in situ, the exact mechanisms underlying SC regulation by the niche remain elusive. To overcome this difficulty, we employed melanocyte stem cells (MSCs), which allow the identification of individual SCs...

...Carol A. Erickson; Tina L. Goins ABSTRACT Neural crest cells are conventionally believed to migrate arbitrarily into various pathways and to differentiate according to the environmental cues that they encounter. We present data consistent with the notion that melanocytes are directed, by virtue...

...Susan D. Porter; Cathy J. Meyer ABSTRACT We have assessed the importance of a melanocyte-specific DNase I hypersensitive site and matrix attachment region situated 15 kb upstream of the mouse tyrosinase gene by analysis in transgenic mice. Transgenes containing all, part, or none of this region...

.../DT probe to investigate the way that the Steel-dickie (Sl d ) mutation interferes with melanocyte development, and found that the membrane-bound steel growth factor which is missing in Sl d /Sl d mutants is necessary for the survival of melanoblasts but not for their early migration and initial...

.... It was concluded that cells recovered from the stage X embryo can subsequently contribute to melanocytes derived from the neural crest, to erythrocytes and to germ cells. This technique of blastodermal cell transfer should be useful in developmental studies and may facilitate the production of transgenic poultry...

... the neural crest. Intermediate cells are melanocyte-like cells, presumably derived from the neural crest, and are scattered between the marginal and basal cell layers. The marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria. The stria also contains...