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Keywords: Mel18
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Journal Articles

Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice

Maki Suzuki, Yoko Mizutani-Koseki, Yu-ichi Fujimura, Hiro Miyagishima, Tomomi Kaneko, Yuki Takada, Takeshi Akasaka, Hideki Tanzawa, Yoshihiro Takihara, Megumi Nakano, Hiroshi Masumoto, Miguel Vidal, Kyo-ichi Isono, Haruhiko Koseki
Journal: Development
Development (2002) 129 (18): 4171–4183.
DOI: https://doi.org/10.1242/dev.129.18.4171
Published: 15 September 2002
... that maintain the state of transcriptional repression of several genes with relevance to development and in cell proliferation. We have identified Ring1B, the product of the Ring1B gene ( Rnf2 – Mouse Genome Informatics), by means of its interaction with the Polycomb group protein Mel18. We describe biochemical...
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Journal Articles

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

Takeshi Akasaka, Maarten van Lohuizen, Nathalie van der Lugt, Yoko Mizutani-Koseki, Masamoto Kanno, Masaru Taniguchi, Miguel Vidal, Mark Alkema, Anton Berns, Haruhiko Koseki
Journal: Development
Development (2001) 128 (9): 1587–1597.
DOI: https://doi.org/10.1242/dev.128.9.1587
Published: 1 May 2001
... complexes to maintain spatially restricted expression of Hox cluster genes. Unlike in Drosophila , in mammals Polycomb group (PcG) genes are represented as highly related gene pairs, indicative of duplication during metazoan evolution. Mel18 and Bmi1 are mammalian homologs of Drosophila Posterior sex combs...
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