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Keywords: Mel18
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Journal Articles
Journal: Development
Development (2002) 129 (18): 4171–4183.
Published: 15 September 2002
... that maintain the state of transcriptional repression of several genes with relevance to development and in cell proliferation. We have identified Ring1B, the product of the Ring1B gene ( Rnf2 – Mouse Genome Informatics), by means of its interaction with the Polycomb group protein Mel18. We describe biochemical...
Journal Articles
Journal: Development
Development (2001) 128 (9): 1587–1597.
Published: 1 May 2001
... complexes to maintain spatially restricted expression of Hox cluster genes. Unlike in Drosophila , in mammals Polycomb group (PcG) genes are represented as highly related gene pairs, indicative of duplication during metazoan evolution. Mel18 and Bmi1 are mammalian homologs of Drosophila Posterior sex combs...