...Dorothea Schulte; Dirk Geerts ABSTRACT MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer...

... forelimb by integrating developmental signals to regulate MEIS expression. Meis Mouse limb development Polycomb Proximal-distal specification RING1 Polycomb group (PcG) genes were originally identified as encoding regulators of Hox genes in Drosophila and are evolutionarily conserved...

... financial interests. 5 12 2013 2 2 2014 © 2014. Published by The Company of Biologists Ltd 2014 Vertebrate limb Patterning Proximo-distal Meis Hox Epigenetics Retinoic acid FGF Chick Mouse Development of the main axis of vertebrate limbs...

... of distal transformation. They also have nuclear MEIS, which can act as an upper arm identity regulator, only upon upper arm amputation. By contrast, myogenic cells do not obey the rule of distal transformation and display nuclear MEIS upon amputation at any proximo-distal level. These results indicate...

... RPCs throughout the period of neurogenesis in the retina, whereas Meis2 is specific for RPCs prior to the onset of retinal differentiation. Transfection of Meis-inactivating constructs impaired RPC proliferation and led to microphthalmia. RNA-interference-mediated knock-down of expression indicated...

... chondrogenesis and, acting as a member of Meinox-Pbc-Hox trimers, it plays an essential role in hindbrain development. * Author for correspondence (e-mail: [email protected]) 27 10 2003 © 2004. 2004 Vertebrate Zebrafish Hox Pbx Meis Prep Rhombomere Segmentation...

... Homeodomain Transcription Repressor Cofactor Pbx Meis The engrailed (en) gene is a homeobox-containing gene crucial for the establishment and maintenance of compartment boundaries during Drosophila development (Akam,1987 ; Blair, 1995). Its homologs in mammals are important in brain and limb...

... for the specification of distal leg pattern elements, and indicate that Dll regulates the expression of as yet unknown molecules required for differential affinities between proximal and distal cells. Distal-less Dlx extradenticle homothorax Meis Msx Pbx Antenna Audition Brain...

...Seong-Kyu Choe; Nikolaos Vlachakis; Charles G. Sagerström Meis homeodomain proteins function as Hox-cofactors by binding Pbx and Hox proteins to form multimeric complexes that control transcription of genes involved in development and differentiation. It is not known what role Meis proteins play...

..., and probably function by revealing the intrinsic specificity of Hox proteins. Vertebrate orthologs of Exd and Hth, known as Pbx and Meis (named for a myeloid ecotropic leukemia virus integration site), respectively, are encoded by multigene families and are present in multimeric complexes together...

...-mail: [email protected]) 14 6 2001 © 2001. 2001 Meis Transcription Activation Homeodomain Imaginal discs Homothorax Drosophila melanogaster The epidermis and cuticle of the cephalic and thoracic segments, the appendages, and the external genitalia of the adult fly...

... for correspondence (e-mail: [email protected]) 22 6 2001 © 2001. 2001 Hox genes Hindbrain Segmentation Transgenic mice Chick embryos Auto/cross-regulation Pbx Meis The Hox transcription factors play important roles in regulating anteroposterior (AP) patterning in vertebrate...

... dominant phenotypes . Development 118 , 401 – 415 . 10.1242/dev.118.2.401 Bürglin , T. (1997). Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals . Nucl. Acid Res . 25 , 4173 – 4180 . 10.1093...

...Muna Abu-Shaar; Richard S. Mann ABSTRACT homothorax (hth) is a Drosophila member of the Meis family of homeobox genes. hth function is required for the nuclear localization of the Hox cofactor Extradenticle (EXD). We show here that there is also a post-transcriptional control of HTH by exd : exd...