...Dorothea Schulte; Dirk Geerts ABSTRACT MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer...

... to regulate MEIS expression. Meis Mouse limb development Polycomb Proximal-distal specification RING1 Polycomb group (PcG) genes were originally identified as encoding regulators of Hox genes in Drosophila and are evolutionarily conserved among metazoans (reviewed by Lanzuolo and Orlando...

...-synthesis enzymes Raldh2 or Rdh10 ( Cunningham et al., 2013 ; Zhao et al., 2009b ). These studies show that hindlimb (but not forelimb) patterning can proceed normally (including Meis expression) in situations in which RA signaling is not detected by a genetically encoded RA reporter ( RARE-lacZ...

... of distal transformation. They also have nuclear MEIS, which can act as an upper arm identity regulator, only upon upper arm amputation. By contrast, myogenic cells do not obey the rule of distal transformation and display nuclear MEIS upon amputation at any proximo-distal level. These results indicate...

... RPCs throughout the period of neurogenesis in the retina, whereas Meis2 is specific for RPCs prior to the onset of retinal differentiation. Transfection of Meis-inactivating constructs impaired RPC proliferation and led to microphthalmia. RNA-interference-mediated knock-down of expression indicated...

... chondrogenesis and, acting as a member of Meinox-Pbc-Hox trimers, it plays an essential role in hindbrain development. * Author for correspondence (e-mail: francesco.argenton@unipd.it ) 27 10 2003 © 2004. 2004 Vertebrate Zebrafish Hox Pbx Meis Prep Rhombomere Segmentation...

... to a larger family of non-Hox homeodomain proteins. * Author for correspondence (e-mail: Jim.Jaynes@mail.tju.edu ) 7 11 2002 © 2003. 2003 Drosophila Embryogenesis Homeodomain Transcription Repressor Cofactor Pbx Meis The engrailed ( en ) gene is a homeobox...

... mediates cooperative DNA binding with Pbx-Meis/Prep1. Nucleic Acids Res . 27 , 3752 -3761. Kohlhase, J., Wischermann, A., Reichenbach, H., Froster, U. and Engel, W. ( 1998 ). Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome. Nat. Genet . 18 , 81 -83...

...Seong-Kyu Choe; Nikolaos Vlachakis; Charles G. Sagerström Meis homeodomain proteins function as Hox-cofactors by binding Pbx and Hox proteins to form multimeric complexes that control transcription of genes involved in development and differentiation. It is not known what role Meis proteins play...

..., and probably function by revealing the intrinsic specificity of Hox proteins. Vertebrate orthologs of Exd and Hth, known as Pbx and Meis (named for a myeloid ecotropic leukemia virus integration site), respectively, are encoded by multigene families and are present in multimeric complexes together...

... homologues. HTH belongs to the Meis family of proteins. These proteins contain both a homeodomain and a Meis-homology domain. The Meis-homology domain is required for their interaction with PBC proteins and the nuclear localization of the latter ( Knoepfler et al., 1997 ; Berthelsen et al., 1998 ; Ryoo et...

... for correspondence (e-mail: rek@stowers-institute.org ) 22 6 2001 © 2001. 2001 Hox genes Hindbrain Segmentation Transgenic mice Chick embryos Auto/cross-regulation Pbx Meis The Hox transcription factors play important roles in regulating anteroposterior (AP) patterning...

... homothorax MEIS Hox extradenticle pbx Drosophila melanogaster In developmental biology, the term selector gene has been used to describe genes that are able to trigger an entire developmental pathway ( Garcia-Bellido, 1975 ). For example, in Drosophila melanogaster the genes eyeless...

...Muna Abu-Shaar; Richard S. Mann ABSTRACT homothorax ( hth ) is a Drosophila member of the Meis family of homeobox genes. hth function is required for the nuclear localization of the Hox cofactor Extradenticle (EXD). We show here that there is also a post-transcriptional control of HTH by exd : exd...