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Keywords: Meiosis
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (11): dev199414.
Published: 08 June 2021
... show that loss of EWSR1 in late meiotic prophase I does not affect proper meiosis completion, but does result in defective spermatid elongation and chromocenter formation in the developing germ cells. As a result, male mice lacking EWSR1 after pachynema are sterile. We found that, in Ewsr1 CKO round...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev194605.
Published: 17 May 2021
... of meiosis, especially in the adult, is not well understood. Here, we reveal that NP95 (also known as UHRF1) and DNMT1 – two essential proteins for maintenance DNA methylation – are co-expressed in spermatogonia and are necessary for meiosis in male germ cells. We find that Np95 - or Dnmt1 -deficient...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (5): dev194977.
Published: 09 March 2021
...Chun-Wei Feng; Guillaume Burnet; Cassy M. Spiller; Fiona Ka Man Cheung; Kallayanee Chawengsaksophak; Peter Koopman; Josephine Bowles ABSTRACT In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( Stra8 ). Stra8 is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197780.
Published: 10 February 2021
...Daniel J. Barbosa; Vanessa Teixeira; Joana Duro; Ana X. Carvalho; Reto Gassmann ABSTRACT The microtubule motor cytoplasmic dynein 1 (dynein) and its essential activator dynactin have conserved roles in spindle assembly and positioning during female meiosis and mitosis, but their contribution to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196931.
Published: 18 January 2021
... regulatory protein 1 (ESRP1) and found that it induced female infertility in mice. Esrp1 deletion perturbed spindle organization, chromosome alignment and metaphase-to-anaphase transformation in oocytes. The first polar body extrusion was blocked during oocyte meiosis owing to abnormal activation of spindle...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
... spermatids ( Figs 3 – 5 ). However, cells recognizable as primary spermatocytes developed ( Figs 5 – 7 ) and progressed through meiotic prophase ( Fig. 6 ). Numerous cell cycle markers indicated that affected spermatocytes entered but did not complete meiosis. Instead, the fully condensed chromosomes...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183764.
Published: 17 March 2020
...Yu Jiang; Hui-Ying Zhang; Zhen Lin; Ye-Zhang Zhu; Chao Yu; Qian-Qian Sha; Ming-Han Tong; Li Shen; Heng-Yu Fan ABSTRACT The most significant feature of meiosis is the recombination process during prophase I. CXXC finger protein 1 (CXXC1) binds to CpG islands and mediates the deposition of H3K4me3 by...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... cells and daughter cells. GSC Stem-cyst Abscission Mitosis Meiosis BMP Bam WDR4 Stem cell self-renewal and differentiation must be balanced for proper tissue homeostasis ( Nakada et al., 2011 ; Simons and Clevers, 2011 ; Spradling et al., 2011 ). This balance is known to be...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev182519.
Published: 02 December 2019
...Jian Li; Ying-Chun Ouyang; Chun-Hui Zhang; Wei-Ping Qian; Qing-Yuan Sun ABSTRACT Chromosome segregation is driven by separase, activity of which is inhibited by binding to securin and cyclin B1/CDK1. In meiosis, premature separase activity will induce aneuploidy or abolish chromosome segregation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178863.
Published: 21 October 2019
... three different genetic backgrounds to manipulate spindle shape without eliminating dynein-dependent movement or dynein localization, we reveal that spindle shape ensures correct orientation at the oocyte cortex to prevent lethal polyploidy. Meiosis Oocyte Spindle The vast majority of...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (8): dev172734.
Published: 26 April 2019
...Enrico Maria Daldello; Xuan G. Luong; Cai-Rong Yang; Jonathan Kuhn; Marco Conti ABSTRACT Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis. Although cyclin B1 (CCNB1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171280.
Published: 04 February 2019
...Hong-Hui Wang; Yu Zhang; Feng Tang; Meng-Hao Pan; Xiang Wan; Xiao-Han Li; Shao-Chen Sun ABSTRACT Cytoskeletal dynamics are involved in multiple cellular processes during oocyte meiosis, including spindle organization, actin-based spindle migration and polar body extrusion. Here, we report that the...
Journal Articles
Journal: Development
Development (2018) 145 (16): dev160614.
Published: 16 April 2018
... males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. Here, we unravel two clearly distinct meiotic arrest mechanisms that occur during prophase of human male meiosis. Type I arrested spermatocytes display severe asynapsis of the homologous chromosomes...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (7): dev163949.
Published: 29 March 2018
... chromosome tethering and identify PUF-8 as a regulator of proteasome activity during early meiosis. * Author for correspondence ( subbu@iitm.ac.in ) Competing interests The authors declare no competing or financial interests. 29 1 2018 5 3 2018 © 2018. Published by The Company...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev156786.
Published: 22 January 2018
... by The Company of Biologists Ltd 2018 Highlighted Article: W/RPRPamide-related tetrapeptides released from neural-type gonad ectoderm cells in response to light cues cause oocyte maturation and spawning in male and female hydrozoan jellyfish. Oocyte maturation Meiosis Neuropeptide...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (22): 4137–4147.
Published: 15 November 2017
...Tadashi Nakagawa; Teng Zhang; Ryo Kushi; Seiji Nakano; Takahiro Endo; Makiko Nakagawa; Noriko Yanagihara; David Zarkower; Keiko Nakayama The mitosis-meiosis transition is essential for spermatogenesis. Specific and timely downregulation of the transcription factor DMRT1, and consequent induction of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3789–3797.
Published: 15 October 2017
... a highly conserved and ubiquitously expressed protein. However, its roles in meiotic oocytes are not known. In the present study, we find that mouse oocytes depleted of HDAC3 are unable to completely progress through meiosis, and are blocked at metaphase I. These HDAC3 knockdown oocytes show spindle...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (19): 3475–3486.
Published: 01 October 2017
...Simon I. R. Lane; Stephanie L. Morgan; Tianyu Wu; Josie K. Collins; Julie A. Merriman; Elias ElInati; James M. Turner; Keith T. Jones Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (11): 1988–1996.
Published: 01 June 2017
...Imrul Faisal; Liisa Kauppi In meiosis, non-exchange homologous chromosomes are at risk for mis-segregation and should be monitored by the spindle assembly checkpoint (SAC) to avoid formation of aneuploid gametes. Sex chromosome mis-segregation is particularly common and can lead to sterility or to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1648–1660.
Published: 01 May 2017
... examined. In mouse oocytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes along chromosome arms during meiosis. The infertility phenotypes of females with a Zp3-Cre -driven conditional knockout (cKO) of Smc5 demonstrated that maternally expressed SMC5 protein is...
Includes: Supplementary data