... of other repressed mRNAs and the mechanism of post-transcriptional repression are currently unknown. Here, we identify the Medea and schnurri mRNAs, which encode transcriptional regulators required for activation and/or repression of Dpp target genes, as additional Pum-Brat targets, suggesting...

...Robert G. Wisotzkey; Arun Mehra; David J. Sutherland; Leonard L. Dobens; Xiaoqing Liu; Cord Dohrmann; Liliana Attisano; Laurel A. Raftery ABSTRACT Mothers against dpp ( Mad ) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD...

... signaling pathway, we screened for mutations that act as dominant maternal enhancers of a weak allele of the dpp target gene zerknüllt . In this screen, we recovered new alleles of the Mothers against dpp ( Mad ) and Medea genes. Phenotypic analysis of the new Medea mutations indicates that Medea , like Mad...

... Smad, Medea , a close homolog of the human tumor-suppressor gene DPC4 . Embryos from germline clones of both Medea and Mad (a class I Smad) are ventralized, as are embryos null for the TGF-β-like ligand decapentaplegic ( dpp ). Loss of Medea also blocks dpp signaling during later development...